Dave and the Citizen Science Foundation are doing important work that typically doesn't get done because there is no drug to sell at the end. Kudos to all of them and thanks to Metabolic Mind for sharing this information.
Right .. Not my words but someone associated our health care system to a cartel.. These are my words .. Racketeering ... IF a health care professional does NOT do what our health care system says you MUST do, this health care professional WILL face some heavy penalty.
Imagine allowing your patient to be fat and diabetic (broken metabolism) because of cholesterol. What are the biggest indicators for CVD risk? Diabetes, Obesity are the top 2. Cholesterol is around number 10. Lose the weight and get your glucose down should be priority #1 for all medical providers. It isn’t. They still think you can’t fix diabetes and insulin resistance 😂. 1970s medicine is what we are still cursed with in America. 3rd world corruption.
Here's a ChatGPT summary: - The study compared individuals with high LDL cholesterol who are lean, metabolically healthy, and on a ketogenic diet (lean mass hyper-responders) to a control group from the Miami Heart Study with average LDL levels. - The lean mass hyper-responders had an average LDL of 272, while the control group had an average LDL of 123. - There was no statistical significance in plaque levels between the two groups, despite the substantial difference in LDL cholesterol. - Participants in the study had been at these LDL levels for an average of 4.7 years. - The study challenges existing beliefs about LDL cholesterol and its role in cardiovascular disease. - The study utilized coronary CT angiography to measure plaque, which is a more advanced imaging modality than coronary calcium scores. - There was no correlation found between LDL levels and total plaque score in both the lean mass hyper-responders and the control group. - The study's cohort actually had a lower area under the curve for total plaque compared to the control group, although this was not statistically significant. - The study raises questions about the context in which high LDL cholesterol may be considered a risk factor for cardiovascular disease. - The study is part of a larger research effort to understand the intersection of metabolic health and mental health, and the potential of metabolic therapies like ketogenic therapy for mental illness. - The study is not meant to refute the LDL hypothesis but to provide more nuanced data on the relationship between LDL cholesterol and cardiovascular disease. - The researchers emphasize the importance of individualized patient care and consultation with healthcare professionals when interpreting LDL levels and cardiovascular risk. - Main message: The study presents compelling data that suggest high LDL cholesterol may not be as significant a risk factor for cardiovascular disease in metabolically healthy individuals on a ketogenic diet, challenging long-held beliefs about LDL's role in heart health.
A fantastic interview, thank you - as a LMHR myself who, at the age of 63, is enjoying excellent metabolic health I have always questioned whether my "through the roof" LDL-C was problematic.
I am also a 67 yr old, male LMHR. I have been on a ketogenic diet for nearly 2-years. My LDL has soarded from about 120 to 270 and total cholestrol is about 360. My doctor was concerned and ordered a CT angiogram. It showed no soft or calcified plaque. I might add my TG is mid 40's and HDL is high 80's. It seems to me that LDL in a vacuum is a poor predictor of CVD.
I’m 65 and about 6 weeks into carnivore. Feeling so much better on many counts! But just had my lipid panel done. LDL at 308 and everyone is literally freaking out. My BMI is 22. TG/HDL ratio is 2.1.
Too many are set in their ways and have letters after their names to then be held over their head to tow the line. Personal problems that are not fixed within the line go past it to find their own answers. Thank you Dave for standing up and challenging the line.
Blood vessel damage in the vasa vasorum is causing plaque buildup. These vessels do get damaged by High glucose (type 2 diabetes), high blood pressure and influenza infection, smoking.
I think, high LDL is a problem if you have other metabolic problems (Diabetes, obesity, High BP etc). But it’s not a problem for metabolically healthy/stable individuals.
But the thing I can't get anyone to say is whether Hi LDL actually matters if there is no damage. the diabetes, obesity, etc stuff are conditions that cause actual measurable damage to the arteries and the bodies, though acidity or turbidity, and the Lipoprotein itself is not the issue. I've heard research doctors suggest that it is the same molecule except for what it is carrying and where it is going. In my mind it's like saying you have too many taxi cabs carrying people to the airport and not enough taxi cabs carrying people from the Airport, but they are the same TaxiCabs except for their passengers. IF those taxicabs carried EMTs and there is an accident on the way to the airport, if the taxicabs detoured to drop the EMTs off to help wounded people on the sidewalk, Then people would say, "We should get rid of the taxi cabs carrying EMTs, because there are too many people on the sidewalk near the accident and it reduces the flow of traffic of the other vehicles that pass nearby!", and that makes no sense, because they aren't going to detour unless there is an accident on their path!
So why isnt it a case of you have diabetes and AS A RESULT your ldl is high. Not an intersection but a consequence. Stress raises cholesterol. Imagine having a heart attack, very stressful, then having your cholesterol level checked.
I'm a 73yo female, hyperresponder to the keto/low-carb way of eating. Three MDs have wanted me to start stations, but one relented when I scored a 0 on the CACS. I don't know what it was before keto, but I wonder if LMHR and low CACS are both results of some underlying metabolic/genetic predisposition? I guess that's what your research is trying to find out.
I’m 74, and diagnosed with cardiovascular disease. I was told my LDL cholesterol is off the charts. I was told my calcium score was extremely high. Every male in my family died at an early age from cardiovascular disease. The only reason I’m alive is because I have been a Raw Foodist for about 24 years and I refuse to take the medicines. The doctors prescribe me.
I'd like to see more comparisons of this group with high LDL but no CAC. To compare their genotypes, blood work, vitamins, types/amounts of antioxidants in the diets. ApoB being only the start of the CAC process these people have something protective going on and identifying them is only the first step.
I am a different case. I have a 1485 CAC Score. So plenty of calcium, but on a following CTA test, pass with flying colors. No blockages, no plagues inside my interior arteries. Cardiologist said he thought my calcium was from outside the arteries in, versus inside out.
LMHR have triglycerides below 70. A lot of people ignore that and think that Dave’s work applies to them but they don’t match the specific definition of LMHR.
So what it’s their health. They choose to feel well over feeling dead. I haven’t seen anything showing LDL is causal. Every egg head acts like it’s known like the vax is super safe and effective. Sure it is. What I have seen is LDL has no added CVD risk when HDL is around 80. Framingham data 3D graph. I’ll take my life without pain as most people who try keto/carnivore do. My body confirms I am doing the right thing. I don’t trust doctors anymore. You lost that and won’t ever be restored.
I would love to know if any of the people studied had a reduction/stabilization in plaque or calcium...For those of us who do have some calcium detected in a CAC test we want to know if there is some hope that eating this way and/or being new on the journey and being LMHR can help improve and/or stop the progression of any cardiovascular disease.
My doctor was concerned my LDL was 124... I had asked for an advanced lipid test so I could see what type, but they didn't do that for me.. HDL was 52 and triglycerides was 80... My BMI is 21.x and I'm not concerned with the LDL number but my doctor was already hinting at meds, which I won't do.
So on Dave’s cholesterol code site it says to keep trigs under 150. But try for under 100. I’ve always had high cholesterol my whole life. I’m about to be 57 years young. I had a CAC of 7 and when I started ketovore in December my trigs were 116 and jumped to 125. HDL went from 50-66. LDL is 307 total cholesterol is 398! ApoB is what I’m worried about because it was 250 but apoa1 is 174. I am also a former smoker and was around second hand smoke my entire childhood. I feel amazing! I had uterine cancer in 2019, with total hysterectomy with no after treatment thankfully. I was 30 lbs heavier.
I was on statins since my early 30s. I believed the corrupt science. BMI 26ish (barely overweight). 37 CAC score at age 50. They didn’t help and likely promoted the calcium. Now I’m ketovore. I don’t trust the science. It doesn’t have any solutions and doesn’t make people well (low fat killed my dad at 60). Just keeps them sick. In my case the statins were pushing me toward prediabetes and promoting calcium buildup. Went ketovore. No more statins for me and was able to drop BP meds with perfect BP. No aches and pains anymore and way more energy and mood is so much better. Quality of life and dementia prevention is my goal. I’m getting that. Didn’t mention how clear my brain is. It’s clear to me now high glucose and oxylates cause memory and thinking problems. Statins cause brain dementia too. Your sorry doc won’t tell you that. No statins for me. Stay away from doctors. Eat beef and eggs.
Thank you for this interview. Thank you too for the explanation of the difference between the CT scan and the CTA scan. It turns out that mine was the CTA which I had at the age of 65 last year, one year after changing to low carb. The result was zero, and with a high LDL with all other metabolic markers good (I'm not lean) and the cardiologist and GP wanting me on a statin (no thank you) I'm glad that I have the baseline test for later comparison.
I dont really worry about high LDL. I eat mostly animal products. Plus some fruit (no salads, veggies anymore). Feel great. I workout regularly as well. I cook everything on lard and dont really care if I ate too much fat or whatever.
@@vincec727 i dont think we really need it. When you think about salads for example, they dont have any taste at all or its bitter. I tried this diet and somehow I dont wanting any veggies anymore. It might be I was only eating it because I thought it was good, not that I needed it. Though with meat, its different. I always want to eat meat:)
31:22 correct, but many of them are failing to do even the most basic due diligence before assuming that. One time last year, some plant activist went through Dave's feed and reposted every single remotely positive comment along with some commentary of their own claiming that all of these people were taking false comfort regarding their bad blood markers because of Dave's work. I know this because one of those comments was mine. This person, who knows nothing about me, or my blood work, assumed because I posted something supportive, that I have high LDL and was doing nothing about it because Dave told me not to. They first assumed all of that, and then publicly asserted it, in an effort to use my comment as ammunition against Dave. The great irony is, I'm not an LMHR and my LDL went down on low carb. I guess, like he says, there are probably good intentions behind that. But that doesn't mean that some of what they do isn't horrifically repugnant and stupid.
Learning for 15 years about all wellness, functional medicine, biohacking... What I see that diet approach fails to address is, how light environment affects metabolic health, starting from cells and circadian clocks in them. And that light alone has much of an affect on cholesterol it's conversion into steroid hormones, etc.
I used to work in darkrooms… and then changed profession and required to take night’s on call… I agree what you’re saying …. Light is energy and has tremendous impact on ours health.
Exactly ! Near infrared from the sun iis cure for for all diiseas specifically inflammatory diseases i live in the hottest place on earth ,average temperature reaches 40 throughout the year, Ethiopia ,afar east Africa .i tell you people have no chronic disease except seasonal malaria despite people consume junk food and processd food and sedentary life. Near infrared is the best antiinflammatory radiation
I did not learn anything from this. Would someone sum up what they said. My cardiologist recently told me that I should be on the highest level of statin. I walked out without it. I think I'm a lean mass hyper responder. So?
Look at your triglycerides to HDL RATIO. 1 OR LESS then most data says your ok. Do your own research. Dr Brett Scherr has great cardiology classes available. I've taken them and they are great.
I'm a hyper responder whose LDL went up to over 700 which is not a good number. Yellow blotches appeared around my eyes and I started having sharp burning pain in my feet, both symptoms of LDL which is too high. Even though my triglycerides and HDL are normal, I have to bring down the LDL to a normal hyper level which is between 300 and 400. Initially it's a weekly statin pill for me plus a daily portion of carbs. Later, hopefully when my LDL is down by half, eating some carbs will be enough to maintain a normal high LDL level.
@@chuckleezodiac24 Feldman is a computer scientist, not an expert in nutrition. Secondly we do know because of body chemistry and you can check with any reputable source that isn't corrupted by industry
BMI is just one of many stupid health metrics. But… how are you calculating body fat. My BMI is 22 and per my scale my BF is 18%. No idea how accurate that is.
My Dad died of heart disease. He never had elevated lipids of any kind. I'm the one with elevated LDL and squeaky clean arteries. So in my world "Bad" cholesterol is just a marketing myth.
Interesting study. When it's published I'll definitely look at it. Looking at one paper or another can be problematic. Until then, I'll stick with the overwhelming consensus by credible science journals which state that a ketogenic diet in the long term for people in some disease states may be advised, but only in the short term. When we look at the long-term effects of a ketogenic diet, while it may offer benefits for certain health conditions, there are many other issues to consider such as: Nutritional Deficiencies: Due to the restrictive nature of the keto diet, there's a risk of deficiencies in essential nutrients, vitamins, and minerals. Bone Health: Some studies suggest that a long-term ketogenic diet may affect bone health negatively, potentially increasing the risk of osteoporosis and fractures. Liver and Kidney Health: The high fat intake can put extra strain on the liver, and the diet's protein content can affect kidney function, especially in those with pre-existing kidney conditions. Heart Health: While some studies indicate improvements in cardiovascular risk factors, the high intake of saturated fats can increase the risk of heart disease in some individuals. Gastrointestinal Issues: The diet can lead to constipation or other gastrointestinal disturbances due to low fiber intake. Risk of Hypoglycemia: For people with diabetes, especially those on insulin or other blood sugar-lowering medications, there's a risk of dangerously low blood sugar levels. Ketoacidosis: Though rare, non-diabetic ketoacidosis can occur, especially in situations like prolonged fasting or alcohol abuse. Mood and Cognitive Effects: Some individuals may experience mood swings or cognitive effects, though this can vary widely. Weight Regain: Long-term adherence to the ketogenic diet can be challenging, and weight regain may occur after returning to a normal diet. Altered Gut Microbiota: The diet can alter gut flora, which may have various health implications. Increased Cholesterol Levels: Some individuals may experience increased levels of LDL (bad) cholesterol. Risk of Chronic Diseases: There's ongoing debate and research about the diet's impact on long-term risk for chronic diseases like cancer, heart disease, stroke, and other neurodegenerative diseases. To get the full scope of a topic, it's important to look for a consensus of credible papers, ensuring a comprehensive understanding that encompasses various perspectives and findings. Risk/Benefit should always be considered when adopting any diet.
We appreciate your measured and balanced language in your comment. While there have been discussions about all of these potential adverse effects, much of the literature and clinical experience has demonstrated them to not be of clinical concern for the majority of people following nutritional ketosis. But, as with any diet or medication, that doesn't mean there is a complete absence of potential adverse effects. It should always come down to an individual risk-benefit discussion when using ketosis as a medical intervention. Thanks.
I had patience, but you lost me at “LDL (bad)”……have you done any research before you made this comment? In fact, not sure why I’m commenting here because I’m sure my comment will not change your perspective…my apologies if this seems confrontational, but all LDL is not bad, it set me off 😊
As a healthy “unvaxxed” 75 year old I have been taking cayenne pepper, Tumeric, vitamins and supplements since the beginning of the pandemic. My BP and cholesterol readings are like a teenager. I have not been sick or had seasonal allergies in (3) years. Both Cayenne and Tumeric have cancer fighting qualities. My recommendation is “Why Not”???
@@a.j.rainey3024 Thank you for your response. As an 81 year old carnivore for almost 2 years, non-vaxxed, and seemingly a lean mass hyper responder looking for answers, I was just curious about your comment. I've found that almost everything I try to add back into my food range causes joint discomfort usually within an hour to a day. I'm learning to be quite cautious. Thanks again.
Irenepeek3211: I eat a couple cheese sticks before my daily vitamin and supplement routine. Anti-Inflamation is the key, both Cayenne and Tumeric should help you, start slowly and gradually increase amounts. Both are inexpensive and for me have a great benefit. Have a great Christmas today.
The responsibility begins with the reader. (s)he has the responsibility to interprete a study in the correct way. The responsibility of Dave and everyone that is involved, is to be realistic, explain the study correctly and to not make it look like more than it is. First step: No One Liners! That will filter 95% of things you shouldn't say. 🙂
If there were teens or young adults who may be considered LMHR would there be a place for them in these studies? If we are not willing to go back to suffering & hospital visits but the price we pay for every other issue healing is high LDL, I wonder if there is a place for LMHR studies including people under middle age.
The effect of all these new findings convinced me that eventually I have to cough up the money to get myself probably tested with the high tech scan used in the study.
the key seems to be oxidized ldl being the culprit but one cant really predict the level of oxidative stress in a modern day human who lives in an "oxidative" environment....get governments to make sweeping changes in our food/water/air/work lives and we should see changes.
Sent this to a GP friend of mine. Here is the unfortunate reply “Thanks Bryan but until all the heart associations of US, SA and Europe change their recommendations, i won’t be convinced. 😊
It's been a bit frustrating for those of us who have been trying to follow certain guidelines since we've had issues. I was told early on to avoid ALL fats. No mention of sugar or carbs at all. So I avoid all fats for 15 years or so. The past 5 years or more I've figured out that some fats are fine. Now the cholesterol levels MAY not play a huge role. I do have high LPa so that MAY play a role but we aren't even sure of that.
This study is awesome news for "lean mass hyper-responders", and it adds to the mountain of evidence against the case that LDL is "bad cholesterol". Therefore, isn't "New Study Questions LDL Risk" the equivalent of "Dog bites man" as opposed to "Man bites dog"?
The fear that these doctors have of the establishment taking their licenses from them for not giving statins is disgusting. The threats against these doctors are awful and one day, we will get to the point where questioning the status quo will not risk your ability to care for your patients. I'm not a willing patient and have had doctors drop me when I refused statins.
Can't get used to Americans referring to 'data' in the plural.. I know that this is grammatically correct but in the UK my whole life it's been referred to in the singular. 😮
If I understand correctly Dave's and Nick's study is highly specific for exclusively LMHR tiny subgroup ... But Not for 2/3 or more of Americans who are not lean but are obese or overweight Majority of Americans or metabolically unhealthy A majority of Americans are insulin resistant For the majority of Americans, therefore the conventional recommendation by the health establishment based on thousands of studies with millions of people is to reduce LDL, to 50 +/- 20, not the still risky, pathogenic 120. And know your genetic, unmodifiable lipoprotein (a) And reduce ApoB
You are correct, and that was a point Dave stressed in this interview - this study is on a very specific group of people who are not representative of the population as a whole. Therefore we need to be careful how broadly we extrapolate the study results.
@@flytoboat There's nothing mindless about reducing LDL specifically. APOB based on thousands of studies on millions of people who are metabolically unhealthy It appears that high LDL for extremely fit and otherwise extremely healthy people is not a problem, not causing arterial plaque AS CVD is a multi-factorial disease, one of the factors is high cholesterol
@@satxsatxsatx so let’s continue to mask the symptoms of metabolic disease instead of fixing the underlying problem. Same old paradigm that doesn’t work.
@@flytoboat The medical profession is sick and degenerate, simple because the most important input to health is nutrition which is not taught in medical schools The current paradigm, fundamentally nothing but predatory capitalism, of treating disease with drugs and medical procedures earns about $3T a year In deeply corrupt and diseased capitalistic America, it is simply impossible to halt capitalism's avaricious predations. The capitalist oligarchy owns the political class and judicial class, and is currently attacking the freedom of thought in education at all levels
I am intrigued by the study. My guess is LMHR were healthy people to begin with. So such a low level of TG, LDL of 123 means they were insulin sensitive, no diabetics I presume. Similarly because of low to zero calcification I assume they were non-smokers as well and chances of not having hypertension. I know these are not mutually exclusive but it seems that was a group without metabolic disease and fairly healthy. What motivated them to follow Keto diet for 4+years which is very extreme diet and hard to follow?
They likely all had different reasons for following a keto diet. And most of them would likely disagree that it is "extreme" and "hard to follow." For many, it is a natural way to eat and very easy to follow. Unfortunately in our carb-centric society, people assume it is extreme and difficult. This may be true for some, but definitely not all.
This doesn't prove that LDL or ApoB can't cause atherosclerosis. But it opens that possibility. And it establishes that LDL does not always cause atherosclerosis. If we're looking for a single cause, the search continues (although I suspect it's primarily a pro-inflammatory pathway--either through tissue or oxidized blood components).
Next time someone calls you an LDL-denier, ask them "is that your term for someone who believes LDL is context dependent, or are you referring to the simpletons who think ldl never matters no matter the context? I'm in the first camp, please don't lump me in with the second camp"
Why do you care what “they” think. As long as it bothers you they will use it. They use name slinging to divert attention away from the naked emperor or the man behind the curtain. Force them to show you the LDL is causal data. It doesn’t exist.
Dave Feldman made the exact same claim with Dr. Cromwell asking point-blank. Isn’t it impressive that there was no statistical difference in plaque between the two cohorts. He said that is not meaningful in one way or another, much Dave Feldman‘s disappointment. I guess it’s a cardiologist versus an engineer.
Dave, i love you and your work and i can appreciate your reluctance to overstate anything but when asked forbthe elevator pitch in conclusion can you be anymore vague in your answer? I mean why say oh its pivotal and leave it at that? Thats ridiculous man, pivotal in what ? Too sheepishly reserved man get convicted as to what EXACTLY it is saying not just leaving us hanging with pregnant phrases what have no meaning ❤
Another nail in the coffin of the lipid heart hypothesis being wrong. Its not the only one.But this is a big one. The cardiology community claims a high LDL is causative in heart disease. That statement is patently wrong.
LDL -> CVD cause and effect has never been established. LDL has never been shown to even associate with CVD. Therefore thinking about how much of LDL any individual should have in his blood at any given time or on the average is a gross waste of time.
Can it be that the LDLin this cohort of people, had mostly large particles that do not stick to the arteries to form plaques compared to the small particles that stick to small "nooks and crannies" and then form plaques?! I have been viewing videos that state the size of particles are the determining factors for plaques in LDL cholesterol....
That's a very good question. While particle size likely impacts atherogenicity, it lsn't as simple as small is bad and large is good. But it does likely impact the degree of risk, especially when the small particles are associated with metabolic dysfunction.
You are correct, they didn't report data on Lp(a) in their initial presentation. As they go through the data for publication we may hear more about that. Thanks!
Did Dave find specific values or characteristics e.g. like smokers, higher hbA1c…in the participants that had plaque versus the ones that didn’t had plaque .
This is a great presentation, Dr. Scher. However, you mentioned that the formal defintion of a LMHR includes an LDL-C over 220mg/dL. I thought the Dave Feldman defintion of LMHR was actually an LDL-C of 200mg/dL or higher. Please advise!
That is correct. Dave defines it as LDL above 200. Sorry for the confusion. In reality, it is such a newly recognized phenotype that the definition will likely be a moving target, but for research purposes, you need a cut off point.
Thank you very much for the prompt reply. Your videos are helping patients around the world understand the mechanisms of metabolic and cardiovascular disease. 👏@@metabolicmind
35:20 Bret noting it takes someone from outside an InGroup to bring new questions - exactly the same happened with cancer research which was stuck in a blind alley paradigm until a physicist with no cancer background was asked to make new sense of the facts. Seeing the same thing with Marc Girardot and Bolus Theory of vaccine injection injury.
Is it "normal" that my cholesterol is 226 measured in the morning after 12 hour fast, but 300 the day after measured in the evening before dinner after a normal day Wondering why the variation and which number is my " actual" number. Any thoughts?
Say you have plaque at a young age of 37 but had great results on keto/low carb and you take a statin but stay on keto for the metabolic and weight management benefit would this be ok? I'm just trying to play it safe as possible and I hated starting a statin but I just felt like I has no choice.
We suggest you follow with a doctor who is familiar with low-carb/keto to help you with your specific situation. You can find one on one of the many directories www.dietdoctor.com/new-and-improved-find-a-doctor-page thesmhp.org/directory/
i think metabolic approach to mental illness is very valuable. I remember decades a go reading about someone Dx'd with schizophrenia whose symptoms disappeared when he was given adequate vitamin B. I'd be more inclined to listen to this whole talk if there were a link provided to the study.
The study hasnt been published yet. It was presented at an inter national cardiology conference. But we will definitely follow up once it has been published.
Good point! The study isn't published yet, it was presented at an international cardiology conference. But we will provide a link once it is published.
I need some help/recommendations. I had a heart attack 10 months ago after being on a high carb vegan diet for 6 years. Now im doing a carnivore diet. This is my cholesterol from 2 days ago! LDL 12.21 mmol/L (or 472 mg/dl) HDL 3.21 mmol/L (or 124.13 mg/dl) Triglycerides 0.73 mmol/L (or 64.66 mg/dl) Doctors want me on heavy statins. I guess i wasnt expecting my LDL to be so high. I'm definitely a LMHR. Bodyfat less than 10%, extremely active and athletic (other than this heart attack)
We are so sorry, but we can't give individual medical advice. You may want to look for a doctor familiar with low carb. You can try the directory here www.dietdoctor.com/low-carb/doctors
@@metabolicmind could you give general personal opinions for a hypothetical person in that situation? With my understanding being that it's not considered medical advice.
I’m similar, I am 50 years old. Eat healthy, mostly low carb, high fat, high protein. Regular exercise. Latest lab results show very high cholesterol and LDL. From what I understand, if the glucose and insulin is good, then the cholesterol is not an issue. My recent fasting blood work results: Total cholesterol 266 LDL 160 ApoB 133 HDL 93 Triglycerides, 67 Triglycerides to HDL ratio 0.76 A1C 5.7 Fasting glucose, 99 or 5.6 (I exercised before the blood extraction, and I think I got a higher reading due to this) Insulin 4.8 Insulin index 1.19 (Homa IR) I’ in a dilema about the LDL/apoB. Reduce saturated fats or go even lower carb…
@JayJay-un3rp I'm 45. I Workout almost every day. I'm super lean and "athletic"....but I had a heart attack🤷. I think it's the result of a very high carbohydrate diet leading to insulin issues from constant high blood sugar....eating so often and so much. But now my LDL is through the roof. HDL is also extremely high and triglycerides are super low.....which is great. I can take steps to lower LDL, but it was low before my heart attack so I'm not sure what's best to do. Adding in some carbs (even if it's just some fruit) lowers it quickly, but feels like heading going back to what I was doing before when I had the heart attack
This research is biased. It is comparing people who are not on a keto diet. If that group consumes ultra-processed foods (upf) including the sweetened or refined carbs type, that group would be far worse than any other group. A better comparison would have been Mediterranean and vegan dieters (who don't eat upf).
It's so weird how some people will seize on anything that even slightly questions ldl or ApoB while dismissing the mountain of evidence that establishes it as an independent risk factor.
Prove it. You post the data. The statin Comp do most of the studies and post fraudulent data then bull shit drs to push statins. Again post a real third party RCT to prove your assumptions
It is a little disingenuous to be so pleased by the fact that the subject population of the LMHR cohort had low levels of baseline plaque. First, they excluded all of the people with high levels of baseline plaque. This was reported by one of the doctors responsible for designing the study, which he now characterizes as a mistake. Second, we are just trusting their recollection of when they started the diet and coming up with an average. It was very clear that there would be no benefit from a one year study, unless the participants had plaque. So we will learn very little after one year with this study. At best you should be able to have some confidence that if you are extraordinarily healthy, then you will not cause harm if you continue on the diet for one to two years. That’s it. And there have been studies done on metabolicly healthy people. And they all indicate that cardiovascular risk follows ApoB. But if you want to get medical advice from an engineer, then do so at your own peril. The host gives good advice here. Don’t assume this applies to you. Discuss this with your physician.
It appears that is an unfortunate and incorrect rumor that they excluded people with high levels of plaque. Please see their published exclusion criteria here. clinicaltrials.gov/study/NCT05733325#participation-criteria
@@metabolicmind it isn’t a rumor. I can send you the tweets from Dr. Nadosky saying exactly that if you would like to judge for yourself. Anyone with a CAC score above the 75th percentile was excluded on the grounds that this was representative of “atherosclerotic heart disease” which was, the last time I checked, an exclusion criteria for the study. Having this as an exclusion criteria was a mistake, but it was done for safety reasons because it was considered unethical to have someone with CVD in the study who had untreated LDL-C above 190.
@@metabolicmind and if you are a female age 55 or younger than any plaque would cause to exclude you from the study. And if you are a male 50 and younger, it doesn’t take very much plaque to reach the 75th percentile.
As we are not involved in the study, we can't speak to any claims of exclusion that aren't published. But when asking Dave about this rumor, he pointed me to this statement: x.com/realDaveFeldman/status/1747979110775988533?s=20
The radiation dose may vary depending on the scanner and size of the person, but a CAC is usually around 1mSv and CTA is between 2 and 4 mSv at experienced facilities. It is worth asking the specific facility what their average is.
@@metabolicmind thanks. The CAC is low, but i read that the Angiagram can be as high as 10 msv. Like you say, I guess it depends on how modern the equipment is, and of course the size of the person. I guess if you stay within say 50 MSV per year, then there’s very low risk.
I'm not sure about the 50mSV safety claim. I havent heard that before, and every radiation exposure can increase risk. The question always comes down to "is this bit of radiation worth it for the clinical benefits."
@@metabolicmind I was just going by the maximum limits allowed by workers at nuclear facilities. Which is 50 MSV per year. Obviously, they would not recommend such a limit if they did not feel it was safe.
I've got one coming up. I'm told to take a 50mg metoprolol 30 minutes before the scan to slow my heart rate. After I looked into to this, I learned that the lower heart rate needs lower radiation during the imaging. I still think it's a lot less invasive. Does anyone have experience in this with metoprolol?
You don't trust it? What does your head tell you, study by someone who does not gain 1 dollar to get the truth, or institutions who work hand in hand with big pharma.
@@metabolicmind my doc says I have polygenic Hypercholesterolaemia. Before the statins my overall cholesterol was 8.4 mmol/L and my LDL was 6.2 With 20mg of atorvastatin it bought my overall down to 5.1 and my LDL to 3.2, I also had a genetics test which come back saying that I probably do have polygenic but not FH and the LDL-C 12 SNP result was within decile 9 what ever that means. I really don’t want to take statins and keep hearing the new data says that high LDL might not be a bad thing. I just want to make the right decision? P.S a few years ago my results were as follows Total - 7.0 Trig - 1.4 HDL - 1.3 Coronary risk - 5.4 LDL - 5.1 Non LDL - 5.7 I also have a Calcium score that come back as 0 But I was about 37 at the time and am now 40 Any help is much appreciated thanks!
Dave continues to promise hard evidence but, to date, I have not seen data that would overturn published studies. Like others who rely on research to make personal health decisions, I wait patiently.
The case is slowly built. When presented it will be overwhelming. You need to understand something about engineering it's not based on feeling or bull shit. It's based on facts. Those take time to gather correctly. There is not one RCT done by a independent third party tester that proves the LDL hypocrisy and consequent statin push. All the studies were made up by the company to sell they're product.
