Jennifer Doudna delivered her Nobel Lecture on 8 December 2020. She was introduced by Professor Claes Gustafsson, Chairman of the Nobel Committee for Chemistry.
She even mentions other scientists of the past whose works all added to the mountain of info and understanding on the whole issue in her book ‘A Crack in Creation’, great book on explaining the technology in layman’s terms and what’s it like to be on the very edge of a momentous discovery that will directly or indirectly impact all humans going into the future. Considered by many to be the greatest accomplishment in the history of biology. Imagine it to be a simple to use tool like a word processor on DNA, add/change/delete any single letter or sequence of letters in the DNA (A,C,G,T) nucleotides. I hope sickle cell anemia, a genetic disease , can be forever eliminated in the not too distant future, as I recollect it’s caused by a wrong single letter in the DNA. Incredible and awesome.
you guys do realize that there is an on-going patent dispute with the Broad Institute right? just because she won the Nobel prize for this, doesn't mean she holds all the key patents of CRISPR.
@@charmander777 You do realize that she and a female co-creator, Charpentier are the only one's credited with this discovery? They did it first in a test tube, and then this guy came along and copied their process into a human....These women are the sole Creators of Crispr...
Not at all.... They are actually rock stars of their field and quite renowned and celebrated in their circle. Yes, that circle might be smaller but the people there are quite enthusiastic and passionate about things they do. Popularity, if you are not actor/politician can become useless in many fields. It sucks away the focus.
Jennifer, thanks to you, I finished my Law School thesis on the need for CRISPR-CAS9 and Ethics to go hand in hand when it comes to the area of Biolaw in Brazil. I was honored to receive top marks and recognition from the evaluators. Thank you for that. Congratulations, for your work and the effort of your team. Award more than deserved.
What really blew me away is that she grew up in my hometown of Hilo, Hawaii and graduated from the same Hilo High school I went to, just 21 years later than me. I’m still in awe and shock. Go Vikings!
I just watched Her co-laureate, Emmanuelle Charpentier present her work. Now seeing Jennifer Doudna talk about her complementary work, it feels like watching a miraculous chemical event that has evolved over millions of years being displayed by the work of these two wonderful scientists and all the people who worked with them and before them. This does raise ethical issues re:all living things. And excitement about the explosion of discovery.
It’s crazy when you think about how these mechanisms have been evolving over billions of years, and how people have figured it out! As scary as it sounds to me, it’s quite a monumental achievement.
I remember hearing a talk by you at my grad school Prof. Doudna :). I was taking a course on bio informatics and genomics and I asked you a question about crispr :). Even though my question was naive and silly you still answered my question with a lot of enthusiasm :). I was so inspired my project for that course was about predicting crispr locations and cutting frequency using machine learning. I am so stoked you got this success. Congratulations :)
I am so happy for both Doudna and Charpentier, inspiring the next generation of scientists, have been following CRISPR Cas-9, from grade 8, now I am in college, someday will be pushing the frontline of science someday along with them
Hope you can someday make a contribution however small, it is that mountain of accumulated knowledge that helped Doudna and Charpentier reach their momentous accomplishment. As have other great scientists.
No question I love everything about you. Now reading Isaacson’s fabulous book about you. I’m so sorry this entire field in chemistry was not known to me in my younger days. I’m 73 now. You are perfect for our times to help avert and stop the destroyers in our days. Love you.
As a layperson, I found her lecture very accessible and interesting!! I too respect the credit and thanks she extends to her colleagues and, in particular, to her graduate students. Well done!!!
Genius work Jeniffer and Emmanuelle. God has really blessed you. Giving great concern to the ethical and social outcome of applying this technology is really another important issue to be dealt with.
It's really wonderful to hear such a clear and compelling lecture. Excited to see Crispr used in ethical ways to solve big problems facing humanity. Also impressive is how everyone she worked with was mentioned by name
A comprehensive thought by Prof Jennifer, so nicely presented the technology and its immense potential and possibilities in present and future applications including covid19. The technology appears to be a magical wand. Its always the experience which comes to the forefront in justifying the thoughts judiciously. Thanks Jennifer for such sincere effortI that is going to change the future of humankind in a silent way. Dr. Gyanesh Kumar Satpute, Senior Scientist, ICAR - Indian Institute of Soybean Research, Indore India 🇮🇳
@ 13:00 this is extremely easy to understand "layman terms" on what is happening within the cell when CRISPR is introduced. What an amazing woman. Let's hope going forward technologies such as these will be used in constructive means to advance all living systems.
We knew about CRISPR in the 1970s or early 80s in Masbate, Masbate, Philippines. I was scanning live the process using a lensing technique and monitoring it using perhaps a "crisp" hologram. In the 1980s, they went to me again about CRISPR and we knew then Doudna and Charpentier will win the Nobel Prize for this.
If any size biopsy were collected could the cancer cells mitochondrial DNA be sequenced? If so could the cancer specific mtDNA be scrambled so the cancer cells starve?
Congratulations. Genius work by Jennifer and Emmanuelle. No doubt that the Noble minds produce Nobel prize winning scientists. That in turn helps the humanity to move forward. Hope this new invention will soon replace from the present medicine system for treating sickness to the Bio tech system.
It would be very interesting to know how the Nobel committee decided the awardees given the ongoing disputes over the intellectual property rights for crispr-cas9.
Some consider it the greatest accomplishment in the history of biology. I think so too, being able to edit a single nucleotide or letter in the DNA sequence is incredible. Like a word processor of DNA, add delete change any single letter or sequence of letters. Changing the very essence of an organism’s attributes. In here book she mentions others creating mini-pigs the size of a small dog, changing the patterns in a butterfly’s wings, some day bringing back extinct creatures. I recently read about experiments where a portion of a poisononous spider’s DNA was put into the DNA of a fungus. This made the fungus have spider toxin that was deadly to malaria carrying mosquitos. Incredible stuff.
Seems like that's coming from the conformational change of CAS-9 which in turn comes from random thermal motion. I'm not sure though, I didn't look through details, but apparently it doesn't need ATP. Still don't feel shy to correct me.
can we cas9 the damaged cells 'dna' in a mechanically damaged cervical disk and replace with an injection of healthy cells from another disc thus fixing the disc ???
I note that in announcing the Nobel prize winner, the committee only gives out the name but leaves out any indication of background, the associated university or company, city, country, and continent. They might as well leave out the planet too .
When already there were gene editing techniques like TALEN & ZFN which are also very specific to the sequence of our interest, so why CRISPR-Cas9 is presented as something very novel ? I mean, I still cannot understand that why the world is talking about CRISPR when there are already gene editing techniques existing ?
This is profoundly Groovetastic 💝😎🔬💊💉🧫🧪 I'm so Exponentially excited about what Dr.Doudna's discovery will deliver to the advancement of mankind from medicine to biotech. CRISPR-CAS9 will transform human life. It's truly the most important discovery in decades.
Considered by some to be the greatest accomplishment in the history of biology. And you can see why it is an incredible tool for future scientists. DNA manipulation to the smallest degree, a single (or chain) nucleotide can be edited. Resultant change will be carried forward into future generations of the organism. Incredible.
