I'm not sure if it's the most effective strategy, but its the safest strategy I've come up with. The reasoning behind removing every gun except the pistol is that: - Every gun will one-shot regular enemies, so it doesn't really matter what gun I use. However, giving every enemy a pistol means that they'll deal less damage. - The pistol shoots as fast as you can click regardless of fire-rate buffs/debuffs. Black Market + Chenrezig turns the pistol into a boss-shredding monster.