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Patchwork People 

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Let's talk of chimeras and mosaics and people.
Transcript here:
freethoughtblogs.com/pharyngula/2024/06/20/patchwork-people/
Identical twins, one case of Down syndrome: www.latimes.com/science/sciencenow/la-sci-sn-twins-down-syndrome-genetics-20140416-story.html
The fusion of two sisters into a single woman suggests that human identity is not in our DNA: english.elpais.com/science-tech/2024-05-08/the-fusion-of-two-sisters-into-a-single-woman-suggests-that-human-identity-is-not-in-our-dna.html
Jeremy Thorpe, Ikeoluwa A. Osei-Owusu, Bracha Erlanger Avigdor, Rossella Tuplerl, Jonathan Pevsner (2020) Mosaicism in Human Health and Disease. Annu. Rev. Genet. 2020. 54:487-510.
Vijg J (2000) Somatic mutations and aging: a re-evaluation. Mutation Research 447: 117-135.
Thompson DJ et al. (2019) Genetic predisposition to mosaic Y chromosome loss in blood. Nature 575:652-657,
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21 июн 2024

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Комментарии : 18   
@TheDanEdwards
@TheDanEdwards 11 дней назад
*SHE HAS TWO SOULS!!* (Just wait for it....)
@thomasneal9291
@thomasneal9291 11 дней назад
I wish more people would watch things like this. keep puttin' them out there.
@dipi71
@dipi71 11 дней назад
I get why science-fiction authors like Neal Stephenson (»Seveneves«) or Scott Sigler (»Nocturnal«) use aspects of epigenetics and chromosomal variation for their stories as a plot device so effectively. It sounds like fiction to most people who didn't get any education beyond flowers, bees, and which sex has which dangly bits.
@bengreen171
@bengreen171 11 дней назад
Very interesting. Aside from the obvious connotations this has in our modern world - is there a possibility that this sort of thing has a role to play in the extinction - whatever that means - of species throughout history?
@AnnaAnna-uc2ff
@AnnaAnna-uc2ff 11 дней назад
Thanks.
@brucecook502
@brucecook502 11 дней назад
😎
@mikefochtman7164
@mikefochtman7164 10 дней назад
Interesting stuff. So, quite simply, my DNA is not what I was born with ;) (I know that's being overly simplistic, but it is interesting to see how it shifts and actually changes with age)
@qwertyuiopgarth
@qwertyuiopgarth 10 дней назад
????? Are there examples of conjoined twins who are genetically distinct? I thought they were always identical twins that didn't quite fully separate.
@timblanchard3539
@timblanchard3539 9 дней назад
This should be required viewing for the gender-fixed-at-conception/birth folks. No, it doesn't address this topic directly and yes, very few will have the scientific chops to grasp much of the argument but the obvious fact of cytological/developmental/environmental (not just genetic) variability contributing to the individual pre and post birth might make some impression.
@allanbilbao6614
@allanbilbao6614 11 дней назад
I love watching PZ debate creationists😂
@P.funkei
@P.funkei 9 дней назад
17:36 What's the significance, if any, in the increased or stable H4 acetylation at the age of 50 in graph (B)?
@PZMyersBiology
@PZMyersBiology 7 дней назад
I don't know, but H4 acetylation is a precursor to replication. The main point of the figure is that the H4 acetylation becomes discordant in older twins.
@8DX
@8DX 7 дней назад
I mean don't the mutations in each (or a large percentage of, since conception) of our cells mean we're all a kind of patchwork anyway?
@8DX
@8DX 7 дней назад
(even if most mutations aren't coding or important)
@PZMyersBiology
@PZMyersBiology 7 дней назад
Yes.
@8DX
@8DX 7 дней назад
Oh, that's what mosaicism is and the subject of the video =)
@thedarkmasterthedarkmaster
@thedarkmasterthedarkmaster 4 дня назад
The same guy who called his blog the "free thought" but then banned Thunderf00t for simple disagreement you have no principles