Pathophysiology of Diabetic Nephropathy 

would it be possible for you to create a video dealing with URINALYSIS? and what type of findings would you expect to find in urine dipstick and under microscope for a patient with different types of renal disease, such as glumerolonephritis, TN, diabetic nephropathy and others? IT WOULD BE MOST APPRECIATED

my second question is that we classify renal failure into 5 main classes according to the GFR of the patient in CKD 5 the GFR is less the 15ml/min so will all these patient's develop uremic syndrome?

i do appreciate of your work, understand it more,but i am not pretty clear about mesangial physiology! i wish i can see it more from your video! oh,if it possible for you to upload the pulmonary disorder and its pathophysiology? i think i am capable to understand by your video than other's. thanks before hands!

Where have you been all this time? Your videos are so simple to understand and I understand the information much better than when I read my books :-)

From all sources I've gathered concerning this, only similar thing ive found is stage one. The rest of the stages are different from every source and now i don't know what is true and what is not😳

Your videos are very helpful. I am a paramedic and RN and they have increased body understanding of so many body systems. I appreciate your investment of time and hope to see more videos!! Thank you!!

Thank you so much for helping me understand the finer aspects of renal physiology! I HATED it as an undergrad as i didn't understand it. Now as a Masters student, i had no choice but to learn... thanks so much!

Hi. Is the biggest cause of Diabities high blood sugar and high glucose. Does the High Bp damages the blood vessels of the kidneys leaving them ineffective over long period of high bp?

Thank you so much,this was pretty helpful

Complex topic simplified to a considerable extent.

Thanks for this very good presentation of the mechanism of diabetic nephropathy but it will be good if you include treatment of different stages of diabetic nephropathy .

vasoconstriction of efferent arterioles decrease glumerular pressure and filtration

thank you very much Dr. Andrew, the video is explained properly

In diabetes type 2 there is a decreased sensitivity and so increased resistance to insulin causing the beta cells of the pancreas to secrete more insulin. That is why often their treatment initially involves drugs that increase sensitivity or decrease resistance, but due to continuous stimulation of the beta cells at some point they get damaged and exhausted, and treatment then often includes insulin therapy. atleast that what I understand from it..

why there is increased level of angiotensin 2 in DM?

Man you are awesome i love you ! :)

subscribing ! :)

thank a lot sharing yours knowledge

sound?

solid,,absolutely clear

That explains it in type 2 diabetes. Type 1 is as I'm sure you know characterized by complete lack of insulin. And yet they develop diabetic nephropathy just as well. In type 2s it is due to a heterogenous group of diseases, dislipidemias, HTN...in addition to to diabetes. In type 1 there is only one initiating factor -that it shares with type 2. Is it the effect of hyperglycemia that causes the nephropathy in this case?

what is the role of podocytes in the pathophysiology of diabetic nephropathy.?? and please can u suggest the recent globally accepted classification of diabetic nephropathy

Could you go more in depth into how hyperglycemia damages the nephron?

Thank you, this was so useful :)

Hello. Ur fan from India. Very thankful for ur efforts. GOD bless u :)

Hello, first of all great videos thank you! My question is about the 5 stages.....at stage 2 you said that people will start developing proteinuria does that also correlate to the GFR being mildly decreased? Along with stage 3 and the hematuria will the GFR be moderately decreased?

Hello, I am a Paramedic in NJ. I randomly chose a video to post under, but I have spent countless hours reviewing your videos, often taking notes, to help the night pass by during "downtime". Thank you for the commitment you've made to making them.

thanks for this great and helpful information but i got a question please , does hypertensive nephropathy affect mesangium ? and if not ,why?

HI i found your video quite helpful. but was wondering if you could explain kamilstain wilson lesion/nodule my interpretation of it is because of increased mesangial proliferation in response to mesangial and glommerular dammage the mesangial cells proliferate and eventually form small nodules known as kamelstein wilson nodules? wondering if i'm correct cheers

This was SO HELPFUL!!!

Could you please tell me how non enzymatic glycosylation and hyaline arteriolosclerosis relate to diabetic nephropathy?

Also why does the efferent arteriole constrict? you mentioned free radicals, but what is the reasoning for the efferent arteriole wanting to constrict? or why do the free radicals cause this?

Are all the functions of human kidneys basically the same in animals such as fish, dogs, cattle birds and other animals?

Thank you for your videos. do you have a video about chronic kidney disease?

Thank you :)

thank you for the great explanation! Your videos are very helpful.

Just to add to the wonderful explanation: Increase in GFR initially is caused due to hyalinization of efferent arteriole,which causes vasoconstriction---predisoposes to hyperfilteration injury Meanwhile non enymatic glycosylation of the basement membrane of the glomerules causes injury and leads to proteinuria esp. called as microalbuminuria. ACE inhibitiors prevent the cond'n as efferent arterilole are under Angiotensin 2 control,which causes vasoconstriction, thus giving an ACE would cause dilation of the hyalinzed efferent arteriole nd improve the GFR as well as hyperfilteraion injury.

great video :-)

That was so clear thank you so much

You ARE A-Mazing

you rock !