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PEARL Trial: Results Review with Matt Kaeberlein and Dr. Z | AgelessRx & Lifespan.io Webinar 

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This is an AgelessRx exclusive event for our patients and PEARL trial supporters! As a patient, you will have FREE access to an AMA seminar reviewing the results from the largest and longest trial on Rapamycin for healthy aging. Our Chief Medical officer, Dr. Z, will join Aging and Rapamycin expert Dr. Matt Kaeberlein, and Oliver Medvedik, Ph.D, to review the results and answer any questions.
Dr. Kaeberlein is the co-founder and CEO of Optispan Health. He was also the founding Director of the UW Healthy Aging and Longevity Research Institute, the Director of the UW Nathan Shock Center of Excellence in the Basic Biology of Aging, Former Director of the Biological Mechanisms of Healthy Aging Training Program, and founder and co-Director of the Dog Aging Project. Dr. Kaeberlein’s research interests are focused on biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. He has published more than 200 scientific papers, has been recognized by several prestigious awards, and has Fellow status in the American Association for the Advancement of Science (AAAS), the American Aging Association, and the Gerontological Society of America (GSA). Dr. Kaeberlein is currently the CEO of the American Aging Association and has served on the Board of Directors for the Federation of American Societies for Experimental Biology (FASEB), AGE, and GSA.
Oliver Medvedik, Co-founder of Genspace citizen science laboratory in Brooklyn NY, earned his Ph.D. at Harvard Medical School in the Biomedical and Biological Sciences program. As part of his doctoral work he has used single-celled budding yeast as a model system to map the genetic pathways that underlie the processes of aging in more complex organisms, such as humans. Prior to arriving in Boston for his doctoral studies, he has lived most of his life in New York City. He obtained his bachelor’s degree in biology from Hunter College, City University of New York. Since graduating from Harvard, he has worked as a biotechnology consultant, taught molecular biology to numerous undergraduates at Harvard University and mentored two of Harvard’s teams for the international genetically engineered machines competition (IGEM) held annually at M.I.T. Oliver is also the Director of The Maurice Kanbar Center for Biomedical Engineering at the Cooper Union, New York City. The Maurice Kanbar Center for Biomedical Engineering is open to all Cooper Union faculty and students working on bioengineering projects requiring equipment and space for tissue culture, genetic engineering, biomechanics, and related research. Faculty that is currently using the facility are pursuing groundbreaking biomedical research in such fields as biomedical devices, tissue engineering, obstructive sleep apnea biomechanics also collaborating with several major New York City-based hospitals. The Kanbar Center continues to provide space for undergraduate teams participating in the international genetically engineered competition (iGEM) during the summer, as well as space for courses that offer a biological laboratory component.
Dr. Z is the Co-Founder and Chief Medical Officer of AgelessRx, serves on the board of the International College of Integrated Medicine, and has chaired two of their international conferences. He is the Clinical Investigator for the ground-breaking PEARL trial, the world’s first and largest trial of rapamycin for aging in humans. He is also the Principle Investigator for many upcoming longevity-focused clinical trials. Dr. Z has been involved with multiple successful healthcare startups, including Pill Club, Jack Health, forHims and Modern Fertility. Dr. Z has been passionate about slowing and reversing age-related diseases for 20 years, which led to his decision to co-found AgelessRx. Dr. Z’s vision for AgelessRx is for it to be the go-to platform for all things longevity, to positively impact the lives of as many people as possible.
Recorded on August 27th at 1pm ET.
PEARL Trial paper: www.medrxiv.or...
Disclaimer: We will be taking questions live during the session, but cannot answer any personal health questions. Involvement in this webinar is for informational purposes only and participation in it does not establish a doctor-patient relationship.

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15 сен 2024

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Комментарии : 11   
@Geroscientist
@Geroscientist 13 дней назад
Hevolution is sitting on billions in cash, yet 3 years since its inception it has failed to fund a meaningful clinical trial for rapamycin, widely regarded as the best the longevity field has. I am extremely disappointed in Hevolution's (lack of) leadership.
@jamesgilmore8192
@jamesgilmore8192 8 дней назад
Thanks for this interesting presentation. I'm a methodologist and I can see the large variability present. Before moving onto "larger" trials, I think you should go back to an n=10-20 study with larger dosing, and figure out what is changing over 2-3 months with more measurement (more measures in time and biomarkers relevant to aging) with much greater control of diet, sleep and exercise. Assessing respiratory, digestive, renal, and reproductive (males only?), all of which have been understudied for rapa, would be a good idea, as many of these have easily measured biomarkers that would change within 2-3 months. Once you've done that you can move onto a larger study with a better idea of realistic endpoints.
@jaakdefour7741
@jaakdefour7741 11 дней назад
So, in summary, for males, after a year of rapamycin, the good news is nothing bad seems to happen, the bad news is nothing good seems to happen. The believers can continue to believe, the sceptics can remain sceptic. I'm a 63y male looking for a reason to start taking the weekly pills for my remaining 37+years... this study didn't provide it. I still have a few years of sitting on the fence as mouse studies seem to show that most of the potential benefits can be had when starting rapa at 2/3rd lifespan. Am I missing something?
@jameszeeb8683
@jameszeeb8683 18 дней назад
Promising results. Look forward to learning more, especially if larger RCT can be funded.
@PullmanLeopold-f8p
@PullmanLeopold-f8p День назад
Davis Kenneth Moore Daniel Lopez Cynthia
@swoops41
@swoops41 19 дней назад
Want to confirm the 10mg dose is compounded, correct? And that is different than generic dosing? Sorry if that is covered in the video but so far haven’t seen the distinction.
@jonathonmills3563
@jonathonmills3563 18 дней назад
All the dosage was compounded not generic
@zakkiuddin5551
@zakkiuddin5551 16 дней назад
Is there no any benefit for males
@jloveric
@jloveric 14 дней назад
The dose in this study was low as 10mg compounded rapamycin seems to be equivalent to 3mg generic. Most people take between 6 and 10mg generic.
@tuitehc26
@tuitehc26 12 дней назад
So some of the people taking 5mg compounded may be getting nothing?
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