Describing underlying physiology of Pernicious Anemia, Autoimmune Gastritis, and connections to Subacute Combined Degeneration of the spinal cord and Peripheral Neuropathy. ashpublications.org/blood/art...
Why are "regular doctors" so ignorant of pernicious anemia? General practitioners do not seem to know about intrinsic factor, about the test for intrinsic factor. General practitioners do not seem to know best practice for treating a person with pernicious anemia. I had a pharmacist tell me, with absolute confidence, that sublingual B12 is no more effective in absorption than taking a swallowed pill form of B12. Doctors still test only for B12 levels and with that test assume no pernicious anemia. My doctor has never discussed how I should also be taking methylated B9 and/or SAM-E. My doctor has never tested for parietal cell factor antibodies or homocysteine. General practitioners seem to treat pernicious anemia as if it was a minor, passing issue. Why is this?
Agree. Its an Ego check for all in the medical field... Discovering that my mothers HRT has likey caused my PCOS, excessive bleeding + other conditions to be exacerbated. For a long time, I thought it was all about iron. The things we wish we new 10, 15, 20 yrs ago! Regards and love to all 🩵
And it’s important to note that the intrinsic factor test is only 40-60 percent accurate so as this amazing doctor has said you need to put all, the other factor s together . I had a level of 180 then 130 4 yrs later, before I was treated .My folate was 2 . All my M tests were high .. and I also have every symptom listed. I truly believe if I hadn’t started on daily b12 shots 18 months ago I would have died. Thank you so much to this amazing doctor who if you missed it very lightly also touched on the mylene sheath being affected by b12 deficiency decline in the sheath is also major factor in MS..
Thank you so much. Is it possible for you to provide a link to the physiology diagram in the description at 11mins...? Fascinating learning this for the first time. My Gps always thought I had a mild iron deficiency. I was deteriorating also due to a Candida overgrowth, robbing nutrients. Sublingal B12 has improved my symptoms dramatically within 24hrs. Cheers! Keep up the good work and sincere thanks for putting this up for us on RU-vid 😊 Molly
My son doesn't have IF, so he can't absorb B12. He has been diagnosed with pernicious anemia. We get him.B12 shots regularly methy and sometimes hydroxyl. Should he also be supplementing with B9, folate, or folic acid? I hear so much debate on all thing pernicious anemia. It gets confusing. It took years before finally getting a correct diagnosis. At first, they thought he had MS. This has been a long journey he's on, and it has taken its tole on him physically. He still struggles with his health quite a bit, but he is a lot better than he was 5 years ago. Can he absorb B9 without intrinsic factor? And is there a way to supplement with intrinsic factor 🤷♀️
I'm wondering that as well. In my case, I've got high MCV confirmed by peripheral blood smear, positive IFA, high serum B12 (I've always taken an oral B-complex), and normal B9, MMA and homocysteine. Yet, I've experienced all the severe PA symptoms (neurologic included) and they're resolving very slowly with high dose injections of methylcobalamin. I've injected daily for 2 months now and am still making tiny improvements.
