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The term half maximal effective concentration (EC50) refers to the concentration of a drug, antibody or toxicant which induces a response halfway between the baseline and maximum after a specified exposure time. It is commonly used as a measure of drug's potency.
Kd (the equilibrium dissociation constant) represents the concentration of free drug at which half-maximal binding is observed.
Competitive Antagonists, Irreversible Antagonists, Schild equation, Receptor-Effector Coupling, Spare Receptors, Partial, Agonists, Full Agonists, and Chemical Antagonist
Katzung, Bertram G., Susan B. Masters, and Anthony J. Trevor, eds. "Basic & clinical pharmacology." (2012).
28 май 2013
