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/ speedpharmacology
Opioids, sometimes called narcotics, are a group of drugs that act on the central nervous system to produce morphine-like effects such as pain relief and euphoria. This pharmacology lecture covers topics such as nociceptive pain pathway, role of glutamate, substance P, and calcitonin gene-related peptide (CGRP) in pain processing, endogenous opioids (enkephalins, endorphins, dynorphins), NMDA, AMPA, NK-1, CGRP receptors, opioid receptors (mu, delta, kappa) mechanism of action and side effects of narcotic drugs, development of opioid tolerance and addiction, partial mu-receptor opioid agonist and antagonist. Drugs mentioned include; Morphine, Fentanyl, Hydrocodone, Hydromorphone, Methadone, Meperidine, Oxycodone, Oxymorphone, Buprenorphine, and Naloxone.
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0:00 Nociceptive pain pathway
0:54 Neurotransmission of pain signal
2:57 Endogenous opioids & opioid receptors
4:32 Synthetic opioids
5:29 Side effects
7:19 Opioid addiction
8:50 Buprenorphine
10:02 Opioid antagonist - Naloxone
2 июл 2024