I love how he says ''I hope you enjoyed this video'' as if he didn't just save my ass explaining everything a lot more clearer than any teacher ever could ! Like I more than enjoyed this video !
@Speed Pharmacology, Hello, I apologize for commenting 4 years too late but I just read a recent study where the tolerance of benzodiazepines regarding anxiolytics is inconclusive compared to tolerance of sedation and anti-convulsive properties. In other words, long term usage of benzodiazepines had insomniacs increase their dosage to get the same effect, same with seizures, however regarding anxiety, it still was effective at that dose even after long term usage. Have you heard of anything like this?
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ahhh personal subject. I got hooked on benzos in 93, I had a friend who was in a naval pharmacy. He stole and sold several types oxapam, Xanax restoril halcion and valium 100$ for 100 pills I took about 900 pills in a few months. In the end I just down the pills like candy. These made me insane. Halcion was really weird, I loved them they gave me energy and enthusiasm Later on 2018, I figured out where to get old barbiturates, I'll just say occasionally an old pharmacy building gets cleared, in storage is many bottles of drugs, I had unopened bottle of secanol amobarbital pheno, barbital butisol cyclo and delvinal, Miltown and amo,dextro speed Speed great Miltown was garbage.maybe it was bad I Never been that wasted, once on seco and pheno I went in to black out, I can not remember 16 days Falling memory blossom and unable to figure out anything, like light switch or remote, dump drinks because you don't know where your mouth is 1 ate 90 1.5 grain pheno but lived. I have been strung out on both Barbs Will kill you
You do such an amazing job at simplifying difficult things with your adorable illustrations and organized points. Thank you for making me enjoy Pharm.❤️
I used benzodiazepines as sedatives for years what will happen is they will become a bigger problem than the reason why you started using them in the first place. If you are using benzodiazepines occasionally and not as a nightly or daily medication . Be careful know the drug you take by taking with your pharmacist who is a chemist 🧪 and knows the effects of medication. Do not tell him why you are taking it this might cause him her to be One sided with what they are telling you. If you ask about a drug that will be the information they give you based on your question and not usage of your medication . Benzodiazepines are 60 times worse than heroin to withdraw from your first month every gram of fat on your body will be eaten to get the drugs out of it then you start withdrawals and it sucks and you may not be capable of working or functioning normally in society . This does not last forever. You need to eat right and not abuse yourself. I know drug addicts and addiction. When a drug addict stops using drugs what happens is your body is trying to heal and you will find that you have more health issues than you believed you had. When you are poisoning your body on a daily basis your body is fighting for your life and is focused on the abuse it is receiving. Once your body realizes that it is not being poisoned daily it will now focus on other problems. As a person who spit my teeth out and tore muscles right off the bone 🦴 because they said they can not help me but I convince them otherwise after the physical damage that was occurring. With benzodiazepines do your research know what you were doing do not rely on anybody else to tell you as well speak with people who have honestly been through it and not pimping a narrative .
A very little known fact is that benzos are actually even more dangerous to quit than opiates like heroine and fentynal. It’s literally the most dangerous class of drugs to quit. I’m not exactly sure why but it kills lots of people who go cold turkey
What phrases can I use to research why Barbiturates have an extreme stimulatory effect on me (think aggressive drunken sailor on speed for many hours). I’m trying to understand how to gain support from a medical system where a majority of drugs cause an opposite intended primary &/or secondary effect. Beyond the redhead gene, and simple allometrics, there must be more useful keywords for me to use in my (as yet) epic blind research. - grateful for any useful insights & references.
Barbiturates snowed me out. Benzodiazepines help my Anxiety disorders greatly. Hypnotic Z-Drugs help when monitored carefully. Was on Zaleplon. Now on Zolpidem 12.5. Sleep great and wake up refreshed. Good video! ✌
I’m a researching parent and have a child with epilepsy. The company Sabril required me to sign a waiver for their drug Vigabatrin. I read that it was a permanent GABA inhibitor and found little else on the subject matter. Could you please do a presentation for how the drug Vigabatrin works on the brain 🧠? Also could you please explain what permanent GABA inhibitors do in other areas such as emotional effects and physical? Thank you 🙏 this information would be very appreciated.
Non-benzos definitely work as anxiolytics. Also zolpidem causes profound hallucinations/delerium at higher doses. Have you covered chloral hydrate and lesser known GABAergic CNS depressants?
My personal (non-medical professional) opinion is that; society shouldn't have banned GHB as a sleep aid. Prescribing hypnotics doesn't seem to provide deep REM 2 sleep in the same way that GHB did for those with sleep issues. I would love to hear your thoughts on this. :)
we also use: - Antihistamines for Situational Insomnia (Hydroxyzine) - Chloral Hydrate for Short Term Treatment of Insomnia (for extremes of age: Elderly and Children) - some Antidepressants/Antipsychotics/Beta Receptor Blockers can be used as Anxiolytics
Do you feel suffocation when overdosing Pentobarbital? You said it can cause death due to respiratory depression but do you fell like you're drowning or suffocating when that happens? Or you get nothing during the process because your brain is shut down? I hope you answer my questions. Thanks in advance!
I'm stiff confused as to how barbiturates attach to the GABAa/b receptor sites, and yet are not supposed to bind to the GABAa/b sites. Aren't they the same place?
Most z-drugs do, in fact have considerable anxiolytic properties. I think that’s also why they are so disinhibiting. You can’t bind to the literal benzodiazepine site as an agonist without producing diminished panic and anxiety.
Fantastic, I have to prepare presentations for some mixed opioid agonist/antagonists and affinity issues to support my literature. Do you use Doodly or anything like that?
Great video on a really important topic. They're really useful drugs medically but the risk of dependency and addiction is not to be underestimate. The difference in mechanism behind benzos and barbiturates has profound implications on the risk of overdose too (hence why barbiturates are barely ever used nowadays). If you're interest in drugs and mental health then check out my channel Mental Health with Dr Elliott. Keep up the good work!
I wanted him to explain how to make these, so many people want to take these meds off the market. if they improve the quality of life for people under a doctor's care, I'm all for them.
i love your videos..They are informative yet entertaining..I wish you would make videos covering drugs used to treat endocrine disorders such as hypo/hyperthyroidism, acromegaly, cushing and addison's disease
The science of benzos is GABA receptor down regulation of the CNS, GI tract, brain, and muscles meaning that natural fight or flight responses are dulled causing people to experience more anxiety, increased panic attacks, more insomnia, increased PTSD symptoms, benzo rage episodes, suicidal ideation, digestive system problems, muscle issues, plus increased eating disorder thoughts and behaviors. The FDA states that physical and psychological dependence on a benzo is not the same as drug addiction. Dependence occurs within a few weeks to a benzodiazapine. Dr.s do not advise patients of the real side effects. The Ashton Manual explains what benzos really do. Tolerance withdrawals occur when taking a benzo as prescribed but the patient experiences worsening panic attacks or other symptoms previously listed. Sadly patients are prescribed higher doses of a benzo when they are in tolerance withdrawals which only causes more issues with the CNS, GI tract, brain, and muscles. Facebook has support groups for individuals who want to safely taper off of benzos. Detox centers treat benzos as opioids. Opioids affect opioid receptors which take weeks to months to taper. Benzos can take months to years to taper. Withdrawal symptoms often happen even after completely off of the benzo for months to years. Research which receptors each Rx drug affects for yourself. Benzos should only be used for seizure disorders. Prescribing benzos for anything other than that is medical negligence. A pharmacist of 25 years states that benzodiazapines can cause neurological damage that can be accidentally diagnosed as ALS, Parkinson's disease, multiple sclerosis, and Alzheimer's disease. #worldbenzoday #wbadrocks
Thank you! I've taken since age 8 PRN, in addition to SSRI and SSNIs. Didnt do enough, got addicted to heroin. My Pharmacist Technicians Lisence was revoked. I've been given detoxes as short as 4 days after being on up to 8mg for over a decade. 6mg a day I can barely make it.
Sadie Schwab I'm so sad for you and I know how you feel as I take benzo,s lorazepam clazepam 4mgs at night to sleep I also take 75 mg of methadone and I hate both of them I wish they would of told me back 2008 how bad they both are and how both are so hard to come off and I,ve tried to stop both of them the clazepam and lorazepam where hell coming off more then methadone ,,,,,,,,methadone you can go down every week or month 1ml but you can,t do this with benzodiazepines as you will not sleep I went like 7 days without sleep til I got my hands on some also your moods are really bad and everything you can think of happens to you shit my life is fucked up now life messed up over these drugs but I keep asking God to help me fine my way with these drugs God bless and best of wishes to you and family
Sadie Schwab I feel so sad 😭 for you I to smoke heroin doctor gives me 30mg mst twice a day 5 mg mst twice a day pregabalin 150 mg 3 times a day Amitriptyline 25 mg twice a day oramorph 5 ml every night Diazepam 5 mg every other day so 1 day on 1day off I was on 80 mg Diazepam 4 10 mg morning 4 10 mg night now it’s a joke 5 mg every other day but I find by talking 900 mg pregabalin 75 mg Amitriptyline 20 mg Diazepam with Grapefruit juice will knock me out for the night and for heroin 150 mg MST twice a day and I am not withdrawing oramorph is useless I drank 300 ml straight it did nothing I tolerate opiates opioids real well anyway take care and be safe
Please clarify (7:37) : "Because alpha-one containing GABA-A receptors are highly expressed in (wick?) - promoting regions of the brain..." I am not well-versed in the brain, so I could not understand this term -- *what*-promoting regions??? Thank you for the assistance.
***So- benzodiazipines can also produce mild muscle relaxation as their result on Gaba receptors in the spinal cord, cerebellum and brain stem- so WHAT happens to a person who's been on benzos for many years- and they have problems with their brain stem or spinal cord- then the benzo is removed and they go into severe withdrawal??? Can anyone answer this? You spelled barbituates wrong. Where do opioids fit into this?
This was perfect! My patient asked why Ambien causes crazy sleepwalking episodes but not so much Ativan... This is perfect for comparing the different gaba binding! Thank you so much
I am 16 and take Zolpidem tartrate once in a month when I am unable to sleep. It makes you go crazy if you do not fall asleep as soon as you take it. The biggest thing is that you do not remember what happened during such a crazy episode. I try hard to remember but it seems as if 90 percent of what happened is forgotten. Therefore, I request everybody to take Zolpidem with caution by taking it JUST 1 MINUTE BEFORE GOING TO SLEEP
Amazing vedio ,it useful alot. I have one doubt sir,that is alpha 2 containing gaba _ A receptors whether these are responsible to produce anxiety or to depress the anxiety.
Still don't get it... how these drugs cause dependence? I'm taking them since 7 years regularly, but if I don't take them for several weeks, I don't feel any change, I don't miss any of them. I use them for my insomnia, I can sleep better with them (since my childhood it's difficult for me to sleep). I know a few people who use Alprazolam the same way like me: sometimes they take them, sometimes they don't. but we all never get mad for this stuff...
Your a diamond in the rough. Some people can stop with zero withdrawal. I stop and withdrawal within 3 days. Even when tapering I have some withdrawal symptoms. I believe 40% of people can stop and have no withdrawal. Feel lucky!
Got prescribed Zolpidem for chronic insomnia. Since my brain hates me and won’t let me sleep. Some of the more odd side effects are as follows: getting into bed to go to sleep, and not falling asleep. This will then lead to a blackout that you will not remember, where you will say incoherent gibberish, appear so drunk that police would estimate your bac to be around .35 and gallivanting around the world in this cognitive state in your bathrobe and pajamas. This will conclude when your family member or local authorities, take you to bed located in either your home, a jail cell, or a hospital. You will then be awoken to the consequences of your actions during this period of hypo lucidity. This can range from: being told to go to sleep after being caught playing fetch with your dogs, in the backyard, in a bathrobe, at 5:30 am in the dead of winter; to being charged with 2nd degree murder. User experience may vary.
