Maryam aziz Roll no 26 Ans: 1 ) Aromatic hydroxylation: propranolol, phenobarbital, phenytoin, phenylbutazone, atorvastatin Reduction: methadone, chloralhydrate, nitrazepam, prontosil, halothane Hydrolysis: aspirin Ans : 2) substituents attached to the aromatic rings may influence the ease of hydroxylation. The process proceed more readily in activated(electron rich) ring whereas deactivated rings( those containing electrons withdrawing groups( Cl, -NR3, COOH, SO2NHR)are slow or resistant to hydroxylation
Samreen nasir (38) Qno: 1 Aromatic hydroxylation:- Propranolol,phenobarbital,phenytoin,phenylbutazone,atorvastatin,ethinyl estradiol,warfarin Reduction:- Methadone(analgesic),chloral hydrate(sadatives and hypnotics),neltraxone(management of alcohol dependence) Hydrolysis :- Aspirin Qno:2 Substituents attached to the aromatic ring may influence the ease of hydroxylation 1)microsomal hydroxylation aromatic reaction appear to proceed most readily activated electron rich rings 2)Deactivated aromatic ring are generally slow or resistant to hydroxylation. Those containing electron withdrawing the group Cl,N,R3,COOH.
1) a: Aromatic hydroxylation (phenytoin & phenylbutazone) b;Reduction nitrazepam (hypnotic & anxiolytic) c: Hydrolysis aspirin ( analgesics & antipyretic) Procainamide (antiarrhythmic). 2)Substitute that effect the aromatic oxidation,it facilitie the aromatic oxidation at high rate that can cause by electron rich species & sometimes it deactivate the aromatic oxidation that can cause by electronegative species like cl,N, R3 , COOH etc. Roll no 23 Joti kumari .
Saira majeed Roll no 36. Ans:aromatic hydroxylation: propanolol, phenobarbital warfarin Reduction:Nitrazepam. Hydrolysis:Aspirin Ans:substitution that effect Aromatic oxidation at high rate that can cause electron rich specie oxidation like cl,N, cooh etc.
Farzana soomro 1.Aromatic hydroxylation , propanol, phenytoin, phenylbutazone, phenobarbital, warfarin 2.Ruduction ,nitrazepam,prontosil, hydrolysis, aspirin,proainamide. Ans.there qre certain substitute that effects the aromatic oxidation. ..... Microsomal aromatic hydroxylation reaction apper to proceed most readily bij activatedb(electron rich ) ring .. ...... deactivated aromatic ring ( we can say electron with drawing group are Cl ,N,R3,COOH,SO2,NHR ,are generally slow or resistant to hydroxylation...
Amna mehmood Roll no 02 Q#1 Ans: Aromatic Hydroxylation (phenobarbital, phenytoin, propanolol, warfarin) Reduction (Methadone, chloral hydrate, natrexone) Hydrolysis (Aspirin, procainaminde) Q#2 Ans As a general rule drug containing activated ( electron rich) ring which favours aromatic oxidation where as the presence of deactivated aromatic ring (containing electron withdrawn group as Cl, N, COOH produce resistance for aromatic oxidation.
Dua Aftab Roll no 12 Ans.1 aromatic hydroxylation eg-phenobarbital,propranolol, phenytoin,phenylbutazone, warfarin,atrovastatin, ethinylestradiol -Reduction eg-methadone,chloralhydrate, naltrexone -hydrolysis eg-aspirin Ans.2 substituents attached to the aromwtic ring may influence the case of hydroxylation some may stimulate the process and some can reduce it because of diff: functional groups are present. Electron rich rings are said to activate the ring while the ring having electron withdrawing groups (Cl,COOH etc) are generally slow or resistant to hydroxylation.
W.slam sir 1.(a) Aromatic hydroxylation Propanolol,phenytoin, warfarin, phenobarbital and phenylbutazone (b)Reduction= prontosils, nitrazepam (c) Hydrolysis= aspirin, procainamide 2) Substitute that effects the aromatic oxidation some time it facilitate the aromatic oxidation at higher rate that can caused by an electron rich species and sometimes it deactivate aromatic oxidation that can cause by electron negative species like N,Cl, R3,COOH, SO2NHR.
walikum asalam sir ans:-1 Aromatic hydroxylation: propranolol, phenytoin, phenylbutazone, phenobarbitol , warfarin. Reduction: nitrazepam, prontosil. Hydrolysis: aspirin, procainamide. ans:-2 1- Microsomal aromatic hydroxylation reactions appear to proceed most readily in activated (electron-rich) rings. 2- Deactivated aromatic rings ( e.g. those containing electron withdrawing groups CL, -N_R3, COOH, SO2NHR) generally slow or resistant to hydroxylation.
Anoosha Qureshi Roll no :03 1- Aromatic hydroxylation, propanolol, phenytoin, phenyl butazone, pheno barbital, warfarin. Ans2: Substitute attached to the aromatic ring facilitate aromatic oxidation at high rate caused by electron rich species sometimes they deactivate the aromatic oxidation cause by electron negative species i.e. CI, N, COOH, R3, SO2NHR
Yusra shaikh Roll no 50 Ans 1 A aromatic hydroxylation propranolol phenobarbital atrovastatin warfarin B reduction nitrazepam hypnotic and anxiolytic prontosil C hydrolysis aspirin procainamide Ans2 Deactivated aromatic ring containing e withdrawing group cl N_R3 COOH SO2NHR are generally slow or resistant to hydroxylation..
Walaikum Assalam Sir! Iram Mehboob Malik Roll No# 22 ANSWERS: Q#1- •Examples of Aromatic Hydroxylation Are: Propanolol, Phenytoin, Phenylbutazone, Phenobarbital, and Warfarin. •Reduction: Nitrazepam, Methadone and Prontosil. •Hydrolysis: Aspirin and Procainamide. Q#2- There are certain substitute that effects the Aromatic Oxidation, •Microsomal aromatic hydroxylation reactions appear to proceed most readily in activated (electron rich) ring. •Deactivated aromatic rings(Like Electron Withdrawing groups {Cl, N, R3, COOH, SO2, NHR} are generally slow or resistant to hydroxylation.
Mahnoor Rehman Roll no :25 Q1: a:Aromatic Hydroxylation examples -Propranolol,phenolbarbital, phenytoin,phenylbutazone, atorvastatin, warfarin b:Reduction examples Nitrazepam and prontosil c:Hydrolysis examples Aspirin,procainamide Q:2 AROMATIC OXIDATION substituents attached to the aromatic ring may influence the ease of hydroxylation. - microsomal aromatic hydroxylation reactions appear to proceed most readily in activated (electron rich)rings -withdrawing groups are generally slow or resistant to hydroxylation
Muqadisa Ahmed Roll no 30 Qno: 1 Aromatic hydroxylation:- Propranolol,phenobarbital,phenytoin,phenylbutazone,atorvastatin,ethinyl estradiol,warfarin Reduction:- Methadone(analgesic),chloral hydrate(sadatives and hypnotics),neltraxone(management of alcohol dependence) Hydrolysis :- Aspirin Qno:2 Substituents attached to the aromatic ring may influence the ease of hydroxylation 1)microsomal hydroxylation aromatic reaction appear to proceed most readily activated electron rich rings 2)Deactivated aromatic ring are generally slow or resistant to hydroxylation. Those containing electron withdrawing the group Cl,N,R3,COOH.
1) Aromatic hydroxylation (phenytoin and phenylbutazone) . Reduction (Nitrazepam and prontosil) . Hydrolysis (Aspirin and procainamide) 2) subsitued attach to the aromatic ring can influence ease of hydroxylation whereas Cl,_N,R3,COOH,SO2 and NHR can slow or resistant hydroxylation
Duaa Amir ali Roll no : 11 Q:no1 1 •Aromatic Hydroxylation Propranalol Phenytoin and phenylbutazone estradoil 2•Reduction Methadone chloral hydrate Nitrazepam prontosil 3•hydrolysis Aspirin & procainamide Q:no 2 It facilitates aromatic oxidation at a high rate which can be caused by electron rich species and it occasionally deactivates aromatic oxidation which can be caused by electro negative species such as CI, N, COOH, and so on
1- Aromatic hydroxylation, propanolol, phenytoin, phenyl butazone, pheno barbital, warfarin. 2- Reduction : Nitrazepam, prontosil Hydrolysis : Aspirin, proainamide Ans. There are certain substitute that effects the aromatic oxidation --- microsomal aromatic hydroxylation reactions appear to proceed most readily in activated ( electron rich) ring --- deactivated aromatic rings ( we can say electron withdrawing groups are Cl, N, R3, COOH, SO2 NHR are generally slow or resistant to hydroxylation.
Sonia Roll no45 Ans1; Aromatic hydroxylation :propanol, phenytoin, phenylbutazone,atorvastatin. Reduction;nitrazepam(hypnotic and anxiolytic)and prontosil. Hydrolysis: aspirin and procainamide(antiarrhythmic) Ans2;Substituents that affect the aromatic oxidation Microsomal aromatic hydroxylation reaction appear to proceed most readily activated (electron- rich )ring whereas deactivated aromatic ring e.g those containing aromatic withdrawal groups Cl,NR3) are gerenally slow hydroxylation.
1- a) Aromatic Hydroxylation: Phenytoin and phenylbutazone . b) Reduction : .Nitrazepam ( hypnotic and anxiolytic ) .Prontosil ( antibacterial antibiotic ) c) Hydrolysis : .Aspirin ( analgesic , antipyretic ) . Procainamide ( antiarrhythmic) 2- Substitute that effect the aromatic oxidation, it facilitate the aromatic oxidation at high rate that can cause by electron rich species and sometimes it de activate the aromatic oxidation that can cause by electro negative species like Cl, N, R3, COOH etc .
Asma umer Roll no 7 Ans 1- Aromatic hydroxylation= propranolol, phenytoin, phenylbutazone, phenobarbital, warfarin. 2-Reduction= Nitrazepam,prontosil. 3-Hydrolysis = Aspirin , procianamide. Ans 2. Substitute that effect aromatic hydroxylation. 1- microsomal aromatic hydroxylation appears to proceed must readily in activated (e-rich) ring. 2- Deactivated aromatic rings (e-withdrawing groups) Cl, N, R3, COOH, SO2NHR are slow or resistant to hydroxylation.
Noor e sehar Roll no:33 Ans:1 i)Examples of drugs undergoing Aromatic hydroxylation: Phenytoin,warfarin,propanolol,phenylbutazone,phenobarbital. ii)Drugs undergoing reduction reaction: Naltrexone,chloral hydrate,Methadone etc. iii)Drugs undergoing hydrolysis reaction: Procainamide,Aspirin Ans:2 Substitution effect the aromatic oxidation by facilitating the aromatic oxidation at higher rates caused by electron rich species and sometimes by deactivating the aromatic oxidation caused by electron negative groups i.e Cl, -N, R3, COOH etc
1. Aromatic hydroxylation means introduction of hydroxyl group in aromatic ring. example :phenylbutazone, Arene, propanolol , phenytoin and atrovastatin. The reduction reaction can takes place in those drugs having aromatic, aliphatic, ketone and aldehydes groups in their structure .examples are :Methadone, chloral hydrate , naltrexone. Hydrolysis reaction takes in those drugs that contain amide and ester group in their structure . Examples are: aspirin and procainamide 2. The substitute that effects the aromatic oxidation some time it facilitate the aromatic oxidation at higher rate that can cause by electron rich species and some time it deactivate the aromatic oxidation that can cause by electron negative species like Cl, N, R3, COOH,SO2NHR
Humera Nasir Roll no:19 Q1:(a) aromatic hydroxylation e.g propanalol, phenytoin, phenylbutazone,atrovastatin,ethinyl estradiol. (b)reduction e.g nitrazepam(hypnotic and anxiolytic.prontosil(antibiotic) (c) hydrolysis e.g aspirin (antipyretic),procainamide (antiarrhythmic). Q2:microsomal aromatic hydroxylation reactions appears to proceed most readily in activated electron rich rings. Deactivated aromatic rings e.g those containing electron withdrawing groups Cl,-N-R3,COOH,SO2NHR generally slow or resistance to hydroxylation.
1) *Aromatic hydroxylation: propanolol, phenytoin,phenylbutazone,phenobarbital,warfarin. *Reduction: Nitrazepam,prontosils *Hydrolysis: aspirin,procainamide 2) substitution that effects the aromatic oxidation it facilitates it at higher rates which can cause by electron rich species and sometimes it it deactivates the aromatic oxidation that can cause by electron negative species.
Name Aresha Rind Roll no 05 1 Aromatic hydroxylation: propanalol, warfarin, phenytoin,atorvastatin Reduction : nitrozepam, prontosil Hydrolysis : Aspirin, procainamide. 2 Substitution effect the aromatic oxidation by facilitating the aromatic oxidation at higher rates which is caused by electron rich species and sometimes by deactivating the aromatic oxidation which is caused by electron negative species.
Bibi Amna 08 Ans.1 Aromatic hydroxylation : propranolol,phenobarbital,phenytoin,atorvastatin,ethinyl,estradiol,and warfarin.. Reduction: Nitrazepam(hypnotic and anxiolytic) Prontosil(antibacterial,antibiotic) Hydrolysis..Aspirin(analgesic antipyretic). Procanamide (antiarrythmic) Ans.2 Substituents attached to the aromatic ring may influence the ease of hydroxylation. 1.Microsomal aromatic hydroxylation reaction appear to proceed most readily in activated (electron-rich)rings. 2.Deactivated aromatic rings (eg.those containing electron withdrawing groups Cl-N R3 COOH So2 NHR are generally slow or resistant to hydroxylation)..
Mahnoor Ali (Roll no.24) Question 01: a) Aromatic Hydroxylation: propranolol, phenobarbital, phenytoin, phenylbutazone, atorvastatin etc. b) Reduction: Nitrazepam, Prontosil, Halothane etc. c) Hydrolysis: Aspirin, Procainamide etc. Question 02: Activated (electron-rich) rings make hydroxylation reactions happen more readily, while deactivated rings (with electron-withdrawing groups like Cl, -N_R3, COOH, SO2NHR) are usually slower or resistant to hydroxylation.
Rabia Roll no: 35 ANSWERS 01: AROMATIC HYDROXYLATION: phenytoin, phenylbutazone, propranolol, phenobarbital, atorvastatin. REDUCTION: methadone, chloral hydrate, naltrexone, halothane. HYDROLYSIS: aspirin, procainamide. 02: 1- In activated (electron rich) ring aromatic hydroxylation reaction proceed more rapidly 2- deactivated aromatic ring are resistant to hydroxylation 3- A compound with two aromatic rings, hydroxylation occur at more electron rich ring
Asma Ujjan Q1: Ans:1)Aromatic Hydroxylation= phenytoin, phenobarbital, phenylbutazone,warfarin,propranolol 2)Reduction=Nitrazepam,prontosil 3)Hydrolysis=Aspirin,procanamide Q2: Ans:substitute that effects aromatic Hydroxylation 1)Microsomal aromatic Hydroxylation appears to proceed most readily in activated(e_rich) ring 2)Deactivated aromatic rings(e-withdrawing groups) cl,N,R3,CooH,SO2NHR) are generally slow or resistant to hydroxylation
Naila Ali Ans 1: Aromatic Hydroxylation refereds to the introduction of hydroxyl group and it takes place in those drugs which contains Aromatic ring in their structure. Ex: Arene, phenobarbital, Ethinyl estradiol, phenylbutazone, atorvastatin etc Reduction reaction take place in those drugs which contains aliphatic, aromatic, aldehyde, ketones in their structure. Ex: Methadone, Nitrazepam, Protonsil, Chloral hydrate etc Hydrolysis reaction take place in those drugs which contains ester and amide in their structure. Ex: Asprin, Procainamide etc. Ans 2: There are certain factors/ substitute that effects the aromatic oxidation like some facilitates aromatic oxidation or occur at high rate and it is caused by electron rich group some retards or cause deactivation of aromatic ring that are electron negative groups like Cl, N_R3, COOH, SO2 NHR.
ANS 1 - a) Aromatic Hydroxylation: Phenytoin and phenylbutazone . b) Reduction : .Nitrazepam ( hypnotic and anxiolytic ) .Prontosil ( antibacterial antibiotic ) c) Hydrolysis : .Aspirin ( analgesic , antipyretic ) . Procainamide ( antiarrhythmic) ANS 2 - Substitute that effect the aromatic oxidation, it facilitate the aromatic oxidation at high rate that can cause by electron rich species and sometimes it de activate the aromatic oxidation that can cause by electro negative species like Cl, N, R3, COOH etc .
Iqra Eman Sodhar Roll no : 21 1 Aromatic hydroxylation: ( Propranolol, Phenobarbital, Atrovastatin ) . Reduction : ( Methadone , Chloral hydrate , Naltrexone ) . Hydrolysis: ( Aspirin , Procainamide ) . 2 Substitute that effect the aromatic oxidation it facilitate the aromatic oxidation at high rate that can cause by electron rich species and sometimes it deactivate the aromatic oxidation that can cause by electronegative species like Cl , N , R3 , COOH etc .
W salam Mehnaz gul unar Roll no 27 Ans 1 Aromatic hydroxylation Example propranolol,phenobarbital,phenytoin, phenylbutazone, phenytoin-p-Hydroxy ,phentoin-o-Glucuronide. b.Reduction Nitrazepam,prontosil,halothane c. Hydrolysis Aspirin, Procainamide. Ans :2 Substitute that effects the aromatic oxidation some time it facilitate the aromatic oxidation at higher rate that can caused by an electron rich species and some time it deactivate aromatic oxidation that can cause by electron negative species like N,Cl,R3,COOH,SO2NHR.
Ans Ex of aromatic hydroxylation Propranolol, phenobarbital, atrovastatin. Ex of reduction Chloral hydrate, naltrexone, methadone Ex of oxidation Acetylsalicylic acid
Aslam Aliakum Sir Sapna Nusrat here roll no (41) Q:01. Ans: The e.g of drugs which undergo A) AROMATIC HYDROXYLATION metabolic reaction are ; Propranolol, Phenytoin, Phenobarbital, Warfarin, Phenylbutazone and Atorvastatin. B) REDUCTION; Nitrazepam which belongs from hypnotic and axiolytic agents, and Prontosil and it belongs from antibacterial antibiotics + Halothane Drugs C) HYDROXYLATION; including esters and amides, Esters= Aspirin ( Analgesic and antipyretic). Amides = Procainamide (Antiarrhythmic) Q:02 Ans: Different substitution can affect or influence the aromatic oxidation in different ways like it can influence it's strength, can stimulate the process, some may reduce, it's all because of possessing different types of functional groups. So substituents attached to the aromatic ring may influence the ease of hydroxylation through activation and deactivation of aromatic rings. Microsomal aromatic hydroxylation reaction takes place quickly in activated rings (Electron-rich). Whereas deactivated aromatic contain electron withdrawing groups like Cl,-N_R3, COOH, SO2NHR are generally slow or resistant to hydroxylation.
Ans 1: Aromatic hydroxylation: propranolol, phenytoin, phenylbutazone, phenobarbitol , warfarin. Reduction: nitrazepam, prontosil. Hydrolysis: aspirin,procainamide. Ans 2: substitute that affect the aromatic oxidation it facilitate the aromatic oxidation at higher rate that can cause by electron rich species and sometimes it deactivate the aromatic oxidation that can cause by electro negative species like cl,N,R3, COOH,etc
Q1# Aromatic hydroxylation: propranolol, phenytoin, phenylbutazone, phenobarbitol , warfarin. Reduction: nitrazepam, prontosil. Hydrolysis: aspirin,procainamide. Q2# Substitute that affect the aromatic oxidation it facilitate the aromatic oxidation at higher rate that can cause by electron rich species and sometimes it deactivate the aromatic oxidation that can cause by electro negative species like cl,N,R3, COOH,etc
Aromatic hydroxylation: E.g :- propanolol phenytoin phenylbutazone warfarin. Reduction: Methadone chloral hydrate nitrazepam prontosil Hydrolysis:- Asprin procainamide Ans 2 Substitution effect the aromatic oxidation by facilitating the aromatic oxidation at higher rates caused by electron rich species and by deactivate the aromatic oxidation which is caused by electron negative species.
Name MurkBhutto RollNo31 Ans (1) Aromatic hydroxylation: phenylbutazone and phenytoin. (2) Reduction: Nitrazepam,prontosil (3) Hydrolysis: procainamide Ans(2)substitue that effect the aromatic oxidation, it facilitate the aromatic oxidation at high rate that can cause by electron rich species and sometimes it deactivate the aromatic oxidation that can cause by electronegative species like Cl, N, R3,COOH etc.
Urooj Fatima Roll no 50 Seat no 48 Example of : Aromatic hydroxylation Atrovastatin, propanol, phenobarbital. Example of : Reduction Chloral hydrate, naltrexone, methadone. Example of : Oxidation Acetylsalicylic acid.
Ans -1 Drugs: Aromatic Hydroxylation: propanolol phenyl butazone, pehno barbital, warfarin, phenytoin. Reduction: prontosil, nitrazepam Hydrolysis: aspirin,proainamide Ans-2 There are certain substitutes that affect aromatic oxidation like facilitate aromation occur at higher rate caused by electron rich group. Some inhibit or retard aromatic ring, like Cl, SO2, NHR etc
Hafsa qureshi Roll no : 16 Qno: 1 Aromatic hydroxylation:- Propranolol,phenobarbital,phenytoin,phenylbutazone,atorvastatin,ethinyl estradiol,warfarin Reduction:- Methadone(analgesic),chloral hydrate(sadatives and hypnotics),neltraxone(management of alcohol dependence) Hydrolysis :- Aspirin Qno:2 Substituents attached to the aromatic ring may influence the ease of hydroxylation 1)microsomal hydroxylation aromatic reaction appear to proceed most readily activated electron rich rings 2)Deactivated aromatic ring are generally slow or resistant to hydroxylation. Those containing electron withdrawing the group Cl,N,R3,COOH.
W.salam sir NAME : Fiza Majeed Roll no :15 Ans 01:- (a) Aromatic hydroxylation : Propranolol, Phenobarbital, atorvastatin, warfarin. (b) Reduction : Nitrazepam (hypnotic & anxiolytic) , Prontosil (Antibiotics) (c) hydrolysis : Aspirin, Procainamide (Antiarrhythmic) Ans 02:- Deactivated aromatic Ring ( containing electron-withdrawing groups Cl, N_R3 , COOH, SO2NHR ) are generally slow or resistant to hydroxylation.
1- a) Aromatic Hydroxylation: Phenytoin and phenylbutazone . b) Reduction : .Nitrazepam ( hypnotic and anxiolytic ) .Prontosil ( antibacterial antibiotic ) c) Hydrolysis : .Aspirin ( analgesic , antipyretic ) . Procainamide ( antiarrhythmic) 2- Substitute that effect the aromatic oxidation, it facilitate the aromatic oxidation at high rate that can cause by electron rich species and sometimes it de activate the aromatic oxidation that can cause by electro negative species like Cl, N, R3, COOH etc .
1. Aromatic hydroxylation means introduction of hydroxyl group in aromatic ring. example :phenylbutazone, Arene, propanolol , phenytoin and atrovastatin. The reduction reaction can takes place in those drugs having aromatic, aliphatic, ketone and aldehydes groups in their structure .examples are :Methadone, chloral hydrate , naltrexone. Hydrolysis reaction takes in those drugs that contain amide and ester group in their structure . Examples are: aspirin and procainamide 2. The substitute that effects the aromatic oxidation some time it facilitate the aromatic oxidation at higher rate that can cause by electron rich species and some time it deactivate the aromatic oxidation that can cause by electron negative species like Cl, N, R3, COOH,SO2NHR
