Polyamines (Including Spermidine) Extend Lifespan: What's My Data?

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Papers referenced in the video:
Spermidine in dementia : Relation to age and memory performance
pubmed.ncbi.nlm.nih.gov/31832...
Polyamine-rich food decreases age-associated pathology and mortality in aged mice
pubmed.ncbi.nlm.nih.gov/19735...
Decreased plasmatic spermidine and increased spermine in mild cognitive impairment and Alzheimer’s disease patients
www.scielo.br/j/rpc/a/S64tCCj...

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20 июн 2023

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Комментарии : 54

@ddutton4716 Год назад

I have eaten 25-50 gm of natto almost every day for 20 years. According to the USDA, this amounts to something like 5-10 mg of polyamines/day. Thanks for these videos.

@SilverFan21k Год назад

Yo Conquer, im glad we have you in the longevity movement. And am happy to see your continued youtube success! 📈🔥

@conqueragingordietrying1797 Год назад

Thanks @SilverFan21k!

@SilverFan21k Год назад

@@conqueragingordietrying1797 i am trying to share your channel, and some others of a list about 10 "Longevity channels", in some discord servers im in. but also dont want to come across as spammy.

@unknmanserbia2642 Год назад

@@SilverFan21k What are the longevity discord servers? Can you share some?

@darkhorseman8263 Год назад

The rare amino acid Ornithine significantly increases polyamine synthesis.

@gregsLyrics Год назад

Michael - the URL for your Metabolomics link is not quite right. It needs a "/" in front of the "?" for your name to be recognized as a patron selects the link. Otherwise, orders are made without your credit. I remain incredibly grateful and impressed at your contribution to us mere humans. :) Thank you for all that you publish and educate.

@conqueragingordietrying1797 Год назад

Thanks @gregsLyrics-it (now) works, and there was confusion about the link for a couple of weeks. If you click on the highlighted portion of the link, it will redirect to iollo, and then one also can use my code for the discount. Now both work (I've seen the applied credit), but it didn't in the beginning...

@user-vr9ws2pr1p Год назад

does supplementing spermidine from wheat germs make sense? I'm not fan of mushrooms.

@SchaferBob1 Год назад

Another great video, Michael! Where do you get spermidine in your diet? Do you source it from wheat germ, mushrooms, broccoli, soy, or something else? There is one study on spermidine in the human diet and its potential impact on aging - American Journal of Nutrition: "Higher spermidine intake is linked to lower mortality: a prospective population-based study" Authors: Stefan Kiechl, Raimund Pechlaner, Peter Willeit, Marlene Notdurfter. There is also this new study that has a lot of references published in 2021: New Insights into the Roles and Mechanisms of Spermidine in Aging and Age-Related Diseases by Yu-Qing Ni. Thank you and keep up the great work and videos!

@conqueragingordietrying1797 Год назад

Thanks Bob, almost exclusively mushrooms, but note that spermidine is also produced by the gut microbiome. I wanted to focus on circulating levels, not dietary intake (as you mentioned), as there is published evidence that dietary intake doesn't impact circulating levels: pubmed.ncbi.nlm.nih.gov/37111071/

@SchaferBob1 Год назад

@@conqueragingordietrying1797 Thanks Michael. Isn't this study about subjects taking spermidine pills and not getting it from whole foods? As you have pointed out, we are better off getting specific nutrients from whole foods as they are better absorbed and are more effective than when they are isolated in pill format. Bryan Johnson gets his spermidine from chlorella in his blueprint plan. Ever thought of adding chlorella to your food list or are you convinced dietary intake of foods with spermidine doesn't matter?

@jamesgilmore8192 Год назад

@@conqueragingordietrying1797 This paper also argues the dynamics of the pathway are more complex: supplementation doesn't increase spermidine levels directly, but spermidine may act as a prodrug which is converted to spermine and this goes into circulation and may enter the cell and be converted back to spermidine. It's possible there is a large reservoir to fill and yes you wont measure changes in serum, but other biomarkers might improve.

@srm6366 6 месяцев назад

Do you have any literature on Spirmadine being too high causing stroke?

@conqueragingordietrying1797 6 месяцев назад

Some studies have shown an association (not causation) for spermidine levels on stroke risk, but conversely, some studies don't show that association: pubmed.ncbi.nlm.nih.gov/38101276/

@jamesgilmore8192 Год назад

Does Iollo output ornithine Michael?

@conqueragingordietrying1797 Год назад

It does, arginine, too

@framexdd Год назад

Does the blood sample sent to IOLLO comes from the tip of the finger?

@conqueragingordietrying1797 Год назад

Hey @framexdd, nope-it uses a Tasso device, which plugs into the arm like a CGM.

@bl3681 Год назад

Just as a heads up: "An overview of polyamine metabolism in pancreatic ductal adenocarcinoma" appears to suggest that high levels of spermidine (and other amines) may assist the growth pancreatic cancer...? I also found a study called "The effect of spermidine on autoimmunity and beta cell function in NOD mice" that seemed to show that mice on spermidine had higher incidences of diabetes. Obviously very specific type of mouse related but might be worth a look...?

@conqueragingordietrying1797 Год назад

Definitely, and thanks @bl3681. Spermidine is produced by the gut microbiome, so I'd bet that's contributing to the too-high is bad for health-story.

@bl3681 Год назад

@@conqueragingordietrying1797 Any time! Is there any reliable data that shows how much spermadine you have to take orally to raise blood serum levels by, say, 1mM?

@jamesgilmore8192 Год назад

Also keep in mind the local environment in cancer can be very different to the circulating. In the NOD mice paper they saw spermidine increase in plasma 1.8-fold, p

@jamesgilmore8192 Год назад

@@bl3681 I don't believe anything like that exists because its hard to measure changes in serum. The epidemiological studies indicate (the one that Michael presented in the previous spermidine video) mid range is ~10mg/day, upper ~11.5mg/day as a start.

@jamesgilmore8192 Год назад

After doing some more digging, studies showing lifespan extension in mice use much lower concentrations in the drinking water around 0.3mM, or they use higher doses for short times. If water consumption is similar between the mice models it appears 10mM across the lifespan is a mega dose for NOD mice.

@aperson1181 Год назад

What are your sources of these substances?

@conqueragingordietrying1797 Год назад

Almost exclusively mushrooms. I covered that in an earlier spermidine video (linked within this video).

@peterz53 10 месяцев назад

MIchael, I've just started using Iollo too but having a bit of trouble interpreting results. My spermidine results for example was fairly good, 4.8 uM and my Taurine was ~100 uM, which Iollo interpreted as optimal. But taurine in the literature and in typical blood tests panels (Quest and Labcorp) is for plasma (or serum) while we provided dried whole blood. Taurine values for whole blood in the literature is a lot higher than plasma for example. Iollo web site does not clarify nor does their AI. From what you know should I be interpreting Iollo results as serum or plasma levels as opposed to whole blood. Even the literature is a bit sloppy in using these terms, or it's my lack of understanding.

@conqueragingordietrying1797 10 месяцев назад

Hi Peter, I wouldn't compare iollo's concentrations to venipuncture-published results, instead focusing on avoiding age-related changes, i.e. decreases for taurine, increases for kynurenine/tryptophan, oxidative stress-related, or uremic metabolites. That's how I'm using their kit...

@peterz53 10 месяцев назад

@@conqueragingordietrying1797 Thanks. But the second concentration graph (2019 paper) was based on plasma in units of nanomole/L (per Table 2) vs iollo result of micrornole/L. Will get back with Iollo as we need to be able to use their result with the literature.

@jamesgilmore8192 Год назад

The Joaquim et al 2019 cohort you compare to are average age 75, much older than yourself. Here is a new paper with a younger control cohort: Positive Correlation between Relative Concentration of Spermine to Spermidine in Whole Blood and Skeletal Muscle Mass Index... Sanayama et al Biomedicines 2023, 11(3), 746. They use controls of average age 45 and compare to dialysis patients. Interestingly it shows the controls have a higher Spermine to Spermidine ratio.

@conqueragingordietrying1797 Год назад

Yes, thanks James

@jisyang8781 Год назад

First! I mean first on second upload.

@N330AA Год назад

Second is the new first

@grugnotice7746 Год назад

I gotta know who is giving these things their names and why.

@edwardburroughs1489 Год назад

Just eat your spermine and don't worry about it, LOL.

@davidderidder2667 Год назад

Haha

@jamesgilmore8192 Год назад

It was first discovered in semen. I think the person who made the discovery named both spermidine and spermine. The chemical name is N1-(3-Aminopropyl)butane-1,4-diamine.

@Elaba_ Год назад

Only 18200 people want to live longer. How do you interpret that data?

@conqueragingordietrying1797 Год назад

Ha @Elaba_, the channel is in diapers, give it time to grow...

@sarpsomer Год назад

Wow, I am suprised there is a hater who is intelligent enough to watch this video.

@Elaba_ Год назад

@@sarpsomer This channel is brilliant. I just can’t understand why it doesn’t have more competition and gets slow traction. Do people have no discipline to improve their health?

@boardcrf2763 Год назад

@@Elaba_ I believe most people do not trust science to increase their lifespan! But once they will witness it which might be too late for them at that time they will follow every thing to extend their lifespan.

@Santa-ny1yp Год назад

@@Elaba_ I suspect most people's eyes glaze over when looking at charts. Many people have these shoved down their throats at work constantly. I enjoy this format because it is different and informative.