Glutathione Restoration Improves Hallmarks Of Aging in Older Adults

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Papers referenced int the video:
Deficient synthesis of glutathione underlies oxidative stress in aging and
can be corrected by dietary cysteine and glycine supplementation:
pubmed.ncbi.nlm.nih.gov/21795...
Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial:
pubmed.ncbi.nlm.nih.gov/33783...
Glutathione declines during aging (Age-related changes in the glutathione redox system):
pubmed.ncbi.nlm.nih.gov/11835...

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11 июл 2024

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Комментарии : 280

@curtisag 2 года назад

What you're doing here is really important. You don't get the exposure you deserve, but know that you are valued and needed by humanity.

@amperage8032 Год назад

Agree! 🤍 This was excellent and well presented. Thank you.

@sciencesimplified3890 3 года назад

this is a freaking incredible video.. this was very easy to follow and understand and huge implications and a clear course of what I should do as the viewer... this was beautiful

@redberries8039 3 года назад

there are question marks on NAC wrt lung cancer

@stellarblur 3 года назад

I'm right there with you science simplified

@astroskate2009 2 года назад

@@redberries8039 Have you got any links for that Green Eggs?

@Coolguyallthetime2k 2 года назад

Agreed. My ears and eyes lit up! So clear, concise and comprehensive.

@billsmith109 Год назад

@@redberries8039 saiting for that link

@edvedder7835 3 года назад

This is great stuff Michael. Thank you so much for taking the time to post this.

@Angel_Dinev 2 года назад

Great video nicely detailing all the intricacies related to glutathione production and its important role in detoxifying the body. Thanks a lot for such hard work to present all this vital info! 🙏

@Bshipbuilder 3 года назад

Wow, so glad this channel came my way.

@AnFr33 3 года назад

One more fantastic and very informative video from Michael. Thank you

@jamespeacock2732 3 года назад

Excellent video presentation and this info is life changing.

@personaltrainingmaster3921 3 года назад

Amazing video🥇 Thanks for sharing Mike!🤸💪💪🙏😀

@aclearlight 3 года назад

Wonderful work! Thank you for sharing this very detailed, exciting result.

@conqueragingordietrying1797 3 года назад

Thanks J. Curtis!

@neerajchopra6809 2 года назад

Well researched . Well explained . Well received by the viewers .

@ottoavila9895 Год назад

Great video Michael!

@ergaus Год назад

Awesome information, very exciting indeed ! thankyou for presenting this in such a clear manner

@ivanandersson 3 года назад

Thanks (besides for the video) for very relevant and insightful thoughts in the comments section. I have to admit, I had forgotten about the dangers of the (old) anti-oxidation theory. It is so easy just to unreflectively add more supplements to the stack, without thinking about their combined potential detrimental effects.

@MrStarchild3001 3 года назад

Wow! This is epic (both the video and the findings).

@conqueragingordietrying1797 3 года назад

Thanks Gokhan!

@wizardatmath 2 года назад

Best job on this topic I've seen yet. Thank you.

@conqueragingordietrying1797 2 года назад

Thanks Omer Feldman Yofiël!

@r.d.7248 3 года назад

Thank you for another excellent presentation! God bless.

@gstlynx 3 года назад

Thanks for another great presentation

@TheReminderChannnel 3 года назад

Absolutely amazing!!! You made this so easy to understand, thank you so much 🙏 👌💪

@azizwafaa8560 2 года назад

جزاك الله خيرا ممكن تشرح لي هذا الفيديو بالعربية

@gordonbriley1579 Год назад

Great video!

@gmc202 3 года назад

Excellent work, thanks

@ccamire 3 года назад

Very good video. I like your reviews and logic. Thanks for all the great work. This is how science advance.

@conqueragingordietrying1797 3 года назад

Thanks ccamire!

@natelf4825 Год назад

Fantastic. Thank you for sharing.

@kSergey83 3 года назад

Wow. Very interesting, thanks!

@ajaxman1000 3 года назад

Another excellent and informative video, thank you Michael. My first thoughts were that, as with other issues such as NAD+, it would be great to find out WHY the levels fall with age so we can try to fix it rather than topping up a leaking tank. That said, in the meantime I'll happily top up that tank if it'll get me home! 😁

@thomasingoglia2227 3 года назад

It declines because of the rising CD38. CD38 requires ~100 molecules of NAD. This is the reason. Not a scientist, but if you boost your thymus and thus your immune system, you could lower cd38 and raise NAD.

@agaragar21 Год назад

Warning! : Taking NAC in older persons can INDUCE crippling Arthritis !!!

@jarrodhockley Год назад

@@thomasingoglia2227 cd38 inhibition is also part of flavaniods within the diet myriad effects.. Apigenin Quecertain etc are targets for CD38 inhibition...

@amperage8032 Год назад

@@jarrodhockley appreciate the reinforcing of practical applications

@neilchristensen538 3 года назад

Fascinating. Thanks!

@rhyothemisprinceps1617 3 года назад

I have misgivings about glycine supplementation in the context of some neurodgenerative diseases (multiple system atrophy), especially big bolus doses. There was research by Lane in the early '90's on it; Lane's case study of an MSA patient with a glycine transporter defect was interesting.

@pavelbaidurov228 3 года назад

Quality content.

@p_peja 2 года назад

I would like to underline about something that is not mentioned in this very informative video. After 12w without GlyNAC supplementation, total RBC GSH levels went back slightly above baseline (0.9 vs. 0.8 of baseline). But inflammatory and DNA oxidative stress markers haven't reach near to base line high values. They were significantly better (yes, not near to "young" levels) but GSH value was only 0.1 better and not close to "young" levels.

@michaelwaldmeier1601 3 года назад

I have been taking glycine 3x per week since last Fall along with other basic molecule / vitamins / mineral supplements. I think the synergistic effect which I notice is the improvement in cognitive intensity and duration for heavy strength training.

@jdholbrook33 Год назад

Excellent video, great information. I knew NAC was good for you but.. wow.. 9g per day? I've taken up to 3g per day and felt strange because of it. Creatine gives me a similar feeling when taking high doses of it (more than 5g). A sort of bloated / swollen feeling. I've been taking 1g NMN, 2g TMG & 1g Apeginin daily for 9 months now and that has been a game changer for me. Looks like I need to add NAC and Glycine to my daily routine.

@stevefantastics6595 3 года назад

Great, thanks! 😁👍

@rickspalding3047 2 года назад

I just started seeing an integrated dr, they are all about nac, they never mentioned adding glycine with it, good to know

@andrewrivera4029 Год назад

Just echoing everything everyone else is saying, great video. My own experience I supplement with NAC and glycine and the phlegm in my lungs has dried up.

@gloglos100 3 года назад

Brilliant, thank you. Michael, thrilled to see your posts going up. Bulk powders Aus has glycine....good price. Bulk nutrients has NAC powder $75 aud for 1 kg. Clearly need to get good price for this . Glycine has multiple good effects and can take much more than 7 g for other issues. Sharry Edwards has picked up glutathione sound signature needed to throww off the virus.

@conqueragingordietrying1797 3 года назад

Thanks janet lesley. If you're going to supplement with glycine+NAC, it's equally as important to blood test, to see if it's working or not. A good start would be the biomarkers in the video...

@pramuanchutham7355 Год назад

Beautiful vdo!...

@conqueragingordietrying1797 Год назад

Thanks!

@stellarblur 3 года назад

Highly important, great presentation Thank you

@conqueragingordietrying1797 3 года назад

Thanks matt jensen!

@stellarblur 2 года назад

I'm thinking the math on Nac is off or I don't understand why they'd give a third more, When the cysteine is only a quarter lower....in the elderly and glycine was lower and they where missing twice the number of glycine/cysteine I took glycine after reading that glycine supplement in mice, Mitigated a high methionine diet, and Increased lifespan almost as high as low protein diet..... I noted greatly increase in circulation, Way lower BP and way lower insulin levels .... I was Trying 3 grams a day.... I've since (this study) doubled that I haven't noticed anything since adding nac.... Except softer skin.... Like two days into a water fast

@conqueragingordietrying1797 2 года назад

@@stellarblur The math isn't off-they used that dose because that's how much it took to restore glutathione to youthful levels.

@stellarblur 2 года назад

@@conqueragingordietrying1797 perhaps it takes two molecules nac for one glycine.... It just seemed strange because the elderly were only 24% lower on cysteine and 55% lower on glycine

@foxxinth 2 года назад

Very good video

@conqueragingordietrying1797 2 года назад

Thanks ian fox!

@charlescottrell8377 3 года назад

Great explanation of the paper!!! I share it and will watch more of your videos. Any thoughts on how many times a day the subjects took the supplements? I read the paper, but it does not mention timing or frequency.

@conqueragingordietrying1797 3 года назад

Good point, I just double -checked the paper and they didn't discuss how many times per day people took the supplements!

@royengstrom4135 2 года назад

Dr. Lustgarten Very good information! My interests are in two areas: 1) Increasing glutathione, and 2) New research in Gut Health, which is also quite exciting lately. Some researchers are talking about returning missing strains to the gut that have some cool functions. Personally, I shall probably use Liposomal Glutathione (1500 mg) with NAC at 5-6 grams, and glycine at 12 grams, and I also take in cofactors like Natural vitamin C, selenium, and natural B vitamins from Beef Liver. Thinking about shortly adding yogurt batches with new strains, and I already eat several fermented veggies. These studies made a great touchstone though.

@andrewj4426 2 года назад

Do not use Liposomal Glutathione as it can cross the blood brain barrier and cannot be metabolized. just use glycine and NAC and you should be able to make plenty of glutathione.

@jp7357 Год назад

Wow .. a boat load of NAC and glycine … when my glutathione drops further I guess I have a path forward … thank you … this is now my favorite channel … 12 down .. lots to go .. am going to revisit the b12 / homocysteine again. I was taking 125mcg of b12 .. going to increase it to 300, try to get homocysteine < 9.

@O8080808O 2 года назад

Hopefully the next study will find the minimum doses required to get these results. This would be very expensive to repeat at home. Also, why wasn't glycine (which dropped the most) given more emphasis/supplementation relative to cysteine? I would like to see a similar study with only glycine supplementation (TMG and no NAC).

@aldousorwell4578 3 года назад

This was a wonderful video. Thank you for producing it! One question that I have is would it be better just to take glutathione supplements instead of cysteine and glycine individually?

@conqueragingordietrying1797 3 года назад

Thanks Aldous Orwell. Someone in the comments posted a paper showing that oral GSH raised blood GSH, so you may want to check that out. In terms of which approach is better, however, no studies have compared glycine+NAC vs direct GSH supplementation.

@aldousorwell4578 3 года назад

@@conqueragingordietrying1797 Thank you. I have down loaded the references and read them.

@KJ-um1gq 2 года назад

Great data, Doc. Can you recommend a brand of Glycine + NAC supplement? Or at least tell us which one you take?

@conqueragingordietrying1797 2 года назад

Hey K J, unfortunately I don't have a recommendation-I'd like to think that all glycine and NAC should be of the same purity, but that may not be true. I don't (yet) take Glycine + NAC, but based on the human data (albeit in small studies), it may be the best option for anti-aging, until there is comparative data against rapamycin and/or acarbose.

@juliusctw 3 года назад

This is really impressive research. And it is conducted on humans. I am surprised by the high dosage and would like to see a longer trial. I'm very grateful that you posted this video.

@joekraska 3 года назад

Yeah, it's a very large amount. Basically 8 pills a day of each supplement. It might work (and be more affordable) as a shake if one used one of the large bulk powdered supplement vendors. This would require that both substances be relatively flavorless; NAC definitely is not flavorless (it's bad), not sure about the glycine.

@michaelwaldmeier1601 3 года назад

@@joekraska I take glycine in a powder form in cold tea.

@kkostadinof 3 года назад

@@joekraska As you said, NAC is pretty bad tasting but glycine tastes like sugar , very pleasant.

@kathleenwildey2757 2 года назад

Excellent information, thanks. I wonder if you have done any studies on Mullein supplementation???? Would be very interested in your results.

@conqueragingordietrying1797 2 года назад

Thanks Kathleen Wildey. Got some studies on mullein for me to check out?

@SportsIncorporated 2 года назад

I take these supplements. The dosages mentioned are multiples of the supplement directions. 600mg NAC would go from 1 capsule to 15.5. 960mg Glycine from 2 capsules to 7.3 capsules.

@Vexx_Line_ 6 месяцев назад

Hello can you please advide.... Is it better to take oral Glutathione, or NAC + Glycine? What are the best products which have adequate levels of active ingredients? Thank you!

@omarguerrero2814 2 года назад

Dr Michael, I am considering taking NAC but I Have read concerned articles about a study done in mice where it promoted cancer. Do you have any thoughts on this?

@conqueragingordietrying1797 2 года назад

Hey Omar, find a lab that measures glutathione, and see if you levels are normal 1st, before doing anything.

@liveto100club6 3 года назад

This was a very interesting subject! Your voice sounds strong and healthy and I imagine your diet has been protective during these times. I too, don't like to supplement, and although i may not be able to achieve the levels of glycine in the study, I can up my levels more than before! Thinking of buying bone broth. What are some other recommended foods to achieve at least higher levels than we had before. I think sprouts too are beneficial for upping glutathione. Could this be related to why older adults need more protein as their ability to absorb these amino acids might be reduced? Thank you for these encouraging videos. Each day we have the potential to be better than we were the day before! Forgot to ask about increasing NAC through diet...

@conqueragingordietrying1797 3 года назад

Thanks Pamela. As you mentioned, supplementation is a last option for me, but based on the doses used, it may be less likely to boost glutathione through diet alone. For ex., my normal intake of glycine+NAC is 4g/day (but not including the amount in sardines, which isn't listed in cronometer). Based on what they used in the papers, my intake is about half needed to maximize GSH, at least in older adults.

@rustybolts8953 3 года назад

@@conqueragingordietrying1797 I have been supplementing with 1.5g/day of NAC for over a year so I know it's safe but have probably been misinformed about safe dosage which your video indicates to be about 9g/day. Also take 2g/day of glycine which I will increase to 4g/day. If you can confirm a recommended dose this would help. I am in excellent and improving heath at near age 70. I take full responsibility for all my own actions so please be assured that no legal accusations will ever be made by myself against you for any recommendations you may make to me.

@conqueragingordietrying1797 3 года назад

No worries,@@rustybolts8953. In terms of a recommended dose, that would be a guess based on the published literature. Beyond that, I'd recommend blood testing to determine if your current dose is detrimental, neutral, or beneficial. With that method, you'll need a few tests (assuming test-to-test variability), and then, altering the doses in conjunction with blood testing can determine how much may (or may not) be beneficial for you. For ex., see my approach with supplementation vs homocysteine, where I'm now only taking methyl B12 instead of methylfolate and B6, which are not significantly correlated in my data: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-y6joAp_UghQ.html

@staceykersting705 2 года назад

@@conqueragingordietrying1797 yeah, I can't afford a lot of supplements. I eat an avocado every day and about every other day, I wilt a huge cello container of organic spinach. I usually have 3 eggs for breakfast and sardines about once-2x a week. I make my own 10 hour bone broth...just toss all your chicken bones in a freezer bag and save up til u have a bunch. all good for glutathione levels. Fasting is THE wonder drug for anti-aging...saves so much money, I can often afford the organic, or grass fed options!

@malcolmlklein 2 года назад

Also, what about Michael Ristow's work that has shown that NAC and other antioxidants can blunt the beneficial effects of exercise by blocking the ROS signaling needed for these responses.?

@conqueragingordietrying1797 2 года назад

That's a separate story that isn't covered in the video, but maybe a future one.

@johnbradford4733 3 года назад

Great videos ! Love the knowledge you impart , I have become an avid fan and am drinking in all your videos since discovering them. I have one question though concerning NAC and it is the concern of long term use of NAC and liver damage. I knew that NAC was used therapeutically for treating overdose with paracetamol but it was reported to have long term effects regarding not allowing the liver to regenerate. I am hoping I am wrong as I would like to start taking both glycine and NAC alongside one another in the amounts you have stressed ie 5 and 9 grams respectively. Any thoughts or opinions on this as I am keen to start this ( I would have taken oral glutathione, but I believe this is ineffective regards its efficacy).

@conqueragingordietrying1797 3 года назад

Thanks John. Above all else, I support blood testing to determine the minimally effective dose, while also minimizing adverse effects on the rest of the body.

@johnbradford4733 3 года назад

@@conqueragingordietrying1797 Thanks Michael for the quick reply, Yes I think I will a follow this , I had a look at the NCBI paper one of your followers suggested and I might go the way of Glutathione for now , even though I have ordered the NAC ( might follow the regimen above until I use up the NAC/ GLYCINE and then transfer to oral glutathione) Again thanks for the reply and advice ps will let you know how the regimen works out, Cheers & Sláinte from Ireland.

@donwestbrook4355 2 года назад

Thank you I got my brother a bottle of nac he tuck them shots now he tired all the time hope it works

@ericwarmath1091 3 года назад

Very interesting

@iwillriseagain1118 Год назад

What was the method of supplementation? Was it free form glycine and NAC, or were they given things like collagen?

@simsammalinao1823 2 года назад

Collagen has a large glycine content.

@kentwestervelt9970 Год назад

Great video. Can we presume (I know this study did not measure) to get the same effects with straight glutathione supplements?

@conqueragingordietrying1797 Год назад

Thanks Kent. Maybe, but I haven't seen any studies directly comparing GSH supplementation with NAC+glycine.

@ahefner33 Год назад

What if you're on other medications? Does that mess up the effectiveness of some medications?

@viracocha2021 3 года назад

Thanks for the video! You have said in previous videos that you plan to not take any supplementation if possible. What are your thoughts in these kind of studies? Are you willing to try them?

@conqueragingordietrying1797 3 года назад

Thanks Viracocha. I'm not anti-supplements, but I favor target supplementation. For ex., I take L-thyroxine for hypothyroidism and Vitamin D in the winter. In terms of senolytics, based on the data in the video, the combination of glycine+NAC may be the best of the bunch, and if I have deficits in inflammation, insulin sensitivity, etc., this combination may be what I take. In support of my current approach, my biological age is relatively youthful: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-U0nTtDmCwSQ.html

@Avital4414 3 года назад

@@conqueragingordietrying1797 do you an opinion on best time for taking NAC; Lipoic Acid; and Glycine? Some brands say take Lipoic Acid with food, but most sources say take on empty stomach. Would taking with coffee reduce absorption?

@conqueragingordietrying1797 3 года назад

@@Avital4414 Hey Rt L. I'm not a fan of general recommendations, but individualized testing to find out the best approach for you. When considering that glycine+NAC can improve insulin sensitivity, one would expect lower fasting glucose, or lower post-prandial glucose as a result of supplementation. That may be an easy way to identify when would be the best time to take them.

@shaggyman8564 Год назад

I most enjoyed this video and felt as if I was back in college taking a course in advanced bio chem. I'm an MD and I love GYLNAC although I don't push it on pts. Pts don't listen. Btw I also sup with 3 g of taurine per day with the GLYNAC. 20 caps per day worth. Sub and like also.

@davidthompson8208 3 года назад

It would be interesting to learn about side effects from those heavy doses. Was there any data on their side effects?

@shaggyman8564 Год назад

I've been taken those HEAVY doses for several months and no side effects

@bpgehm7530 2 года назад

Thank you! Very clear. I don't feel well when I take more than 500 mg of NAC twice a day. Sulfur gas. Is it possible to get these results taking SAGlutathione? Or a combination of lower doses of NAC, glycine & SAG?

@conqueragingordietrying1797 2 года назад

I'm not sure which approach will be best for optimizing blood glutathione (GSG), but GSH and GSSG are commercially available for measurement in blood. One can try different interventions in conjunction with blood testing to sort it out...

@charlescottrell8377 3 года назад

NAC is getting harder to find since Amazon stopped allowing it to be sold and other stores have had a run on it.

@conqueragingordietrying1797 3 года назад

If the goal is to boost GSH, although NAC is now limited, you'd need cysteine, which is commercially available.

@charlescottrell8377 3 года назад

@@conqueragingordietrying1797 Great point! It does beg the question why Cysteine isn’t used in these experiments.

@rangerdoc1029 2 года назад

That dose is HUGE.

@troychristensen8016 2 года назад

Nice...

@rickspalding3047 2 года назад

Coming back to this video as I came across antioxidant supplementation should be taken at night. Seems high to take 9 grams all at once!

@alistairmacgregor1456 2 года назад

glutathione also downgrades graphene oxide in vaccines, it increases the nutrophils in white blood cells and oxides the graphene oxide similar to how the natural hydrogen peroxide in cells work to granulate bad cells, foriegn bodys and viruses, im interested in the bonded glutathion you spoke about in the video, amino acids are key to good health and it is so complicated there are so many, the perfect thing is a full bredth whey proteine shake with added BCAA's branch chain amino acids, eat mediteranian diet and have a shake once a day, also will help the global food shortage.

@stephenburrows1816 Год назад

So now we have to find out how to recycle glutathione like we did when we were young.

@gastropodahimsa 3 года назад

Judging by the insulin sensitivity and glucose slide, these older people were not metabolically health to begin with. I would like to see the study done with people who start out metabolically healthy. Not likely, but still, I would.

@CyrilAndPriscilla Год назад

Are you familiar with the research on supplementing the dipeptide gamma-glutamylcysteine and its effects on raising glutathione? Do you have any thoughts about it?

@conqueragingordietrying1797 Год назад

I'm not familiar with any studies using it to impact glutathione, but it would act as a cysteine donor, which could increase GSH synthesis. However, that's the reductionist version, I'm not sure what the broader systemic impact would be.

@CyrilAndPriscilla Год назад

@@conqueragingordietrying1797 Thanks. I wonder if it would downregulate gamma-GCS in the long run, which might be counterproductive? Anyway, there's the following paper where they gave 2 and 4 g per day of g-GC: where it increased lymphocyte GSH by 53%: "Oral administration of γ-glutamylcysteine increases intracellular glutathione levels above homeostasis in a randomised human trial pilot study." by Zarka and Bridge. I shared the PM ID in another post, but RU-vid deleted it for some reason.

@andrewtaylor9799 2 года назад

This is a very striking result. It's not clear from the video if the dosing used for NAC and Glycine was optimal; it seems possible smaller amounts would be adequate. Also, sulforaphane is supposed to encourage the enzymatic production of glutathione, and could also be beneficial as an accelerator for this. Collagen peptides, made from cowhide, have a large percentage of glycine. I get the grass-fed type, and upped my daily collagen peptide intake from 13 g to about 20 g, which includes about 5 g of glycine. I also started supplementing with NAC, 2.4 grams/day (1.2 grams twice a day). There is an argument that humans traditionally ate much larger amounts of glycine than they do now. This is because humans traditionally ate animal parts other than just the muscle, and these are much higher in glycine. For this reason, the body can only produce something like 3 g of glycine/day - most of the glycine needs traditionally came from the diet - and 3 grams isn't enough in the long term.

@rturtle5795 2 года назад

Curious what brand of collagen peptides do you use?

@andrewtaylor9799 2 года назад

@@rturtle5795 Horbaach

@peterz53 2 года назад

wonder if DNA double strand breaks was reduced. DSBs are a significant driver of aging.

@AN-zg3sr 3 года назад

What is the effect of direct supplimentation of glutathione ??

@pelletey 3 года назад

Thanks for the good video, should we be worried about supplementing NAC due to the study of Vitamin E and NAC increasing liklihood of lung cancer in smokers? It may have just been the Vitamin E which caused it but still a worry.

@rhyothemisprinceps1617 3 года назад

Cancer risk with vitamin E (alpha tocopherol) supplementation was found to be dependent on COMT genotype in women. It lowered risk for those with met/met genotype, but raised it for val/val.

@abritrn 3 года назад

@@rhyothemisprinceps1617 was this specifically in female smokers or just women in general?

@rhyothemisprinceps1617 3 года назад

@@abritrn women in general, they controlled for smoking but it was done differently in the two trials that were analyzed. The study was Hall et al. 2019 'COMT and alpha tocopherol effects in cancer prevention ...' available full text in PubMed

@stevematheson9979 Год назад

One of the key factors is dose. It's a fairly high dose to get these results. The studies show the dose in mmol/kg of body weight. I've converted mmol (milli-moles) to grams to make it easier to figure out the dose. As an example: I weigh 80kg and to get the results in the study I need; 1) glycine - 0.10 gm * 80 kg = 8 gm - cost in bulk powder is about $0.18 per day 2) NAC - 0.132 gm * 80 kg = 10.6 gm - cost in bulk powder is about $1.96 per day Dose matters, they (do you know this is a division of Nestle doing these trials) also did a trial with similar results with less but I'm more interested in maximizing my results If you are paying more, you need to shop around 🙂

@bl3681 Год назад

I wonder if using Liposomal NAC will help to lower the dosage as much of the NAC is getting broken down in the stomach.

@jeffrey4577 11 месяцев назад

Can ggt be used as proxy gor glutsthiine level in blood?

@iwillriseagain1118 Год назад

I'm surprised they supplemented so heavily with NAC, when the decline even by older ages is only 24%. It seems like glycine is the real problem, given it's nearly halved. I'm also surprised you don't supplement Michael. You're getting up there in age. ;)

@conqueragingordietrying1797 Год назад

Ha, I Will Rise Again, have you seen my recent blood test results? I'm open to the idea of GlyNAC, but my data suggests that now is not that time.

@iwillriseagain1118 Год назад

@@conqueragingordietrying1797 Ahh, so you are killing it. I did see your recent blood tests, but I wasn't thinking about it in the context of glycine while watching. I should go back and check. That reminds me though, what blood test do I have to get to check mine?

@conqueragingordietrying1797 Год назад

@@iwillriseagain1118 For aging.ai, the standard chemistry panel and CBC. Add hs-CRP and you can measure Levine's Phenotypic Age.

@iwillriseagain1118 Год назад

@@conqueragingordietrying1797 Thanks!

@thomasingoglia2227 3 года назад

Michael, what supplements do you recommend?

@conqueragingordietrying1797 3 года назад

Hey Thomas, my primary strategy involves using blood testing (or other biomarkers, like blood pressure) to identify a need for a potential supplement. Then, additional blood testing to see if it works or not. For ex., I take Vitamin D in the winter, which is essential. Also, I've taken methyl folate-methyl12-B6 to reduce homocysteine.

@MrStarchild3001 3 года назад

Btw, I thought the (anti-)oxidant theory of (anti-)aging is dead? Does this study & similar study on HIV+ & mice/c elegans studies suggest otherwise?

@conqueragingordietrying1797 3 года назад

Ha, I wouldn't say it's dead, but the origin of that theory was that it was/would be the end-all-be-all of aging theories. From that perspective, it's not, but it's definitely a contributing factor during the aging process. Nonetheless, there's lots of positive data on other aspects of aging that may be more important, including inflammation, insulin sensitivity that are positively affected by GSH restoration. Now, the major question is, will it work in larger populations, or is this an artifact of 2 small studies (n=32 total)?

@riccardofabris1260 3 года назад

I read the study some days ago. I was already a NAC "fan" and glycine too but I was perplexed by cysteine amount which was very high (around 7g for 75kg body weight as I recall), what do you think? BTW I have to lower alcohol consumption, it seems in time of COVID bad habits are easy to take 😉

@conqueragingordietrying1797 3 года назад

The NAC (and glycine) amounts that they used were indeed very high. Also, these findings were in 2 small studies, including a total of only 32 subjects. The same research group is performing these studies, so replicating the supplementation approach in other labs would be nice. Nonetheless, there are a lot of promising findings, many of which I showed in the video.

@riccardofabris1260 3 года назад

@@conqueragingordietrying1797 What about direct intake of (liposomal) gsh?

@conqueragingordietrying1797 3 года назад

@@riccardofabris1260 No studies have compared it against glycine+NAC...

@serbianboss3294 2 года назад

Michael there is a study where chamomile increases glycine. Do we need to supplement glycine if we drink chamomile?

@larsnystrom6698 Год назад

@Serbian Boss Camomille contains Apigenin (but not as much as Parsley). It reduces CD38, which is a big consumer of NAD+. But I don't know if it does anything else. I doubt it does much for Glutathion, though.

@serbianboss3294 Год назад

@@larsnystrom6698 Hi Lars. Thanks for the answer. I know about apigenin, but for that I use dried parsley 3x a day as its the biggest source of apigenin.

@diamond_s 3 года назад

Glycine is easy to obtain, but I hear NAC is being banned from many places. Any other supplement source of cysteine?

@conqueragingordietrying1797 3 года назад

Cysteine is sold on its own as a supplement, and should work just as well as NAC when combined with glycine.

@bl3681 Год назад

They dosed the NAC at 100mg/kg which seems very high as 1800mg is the upper limit of recommended dosage. Is this to try and overpower the breakdown of NAC in the gut and short half-life? If you used, say, Liposomal NAC, could you lower or significantly lower the daily dosage? How would you safely test this on a N=1 study?

@conqueragingordietrying1797 Год назад

The safest way is to start with a low dose, but also with full panel blood testing at each step. That's what I've done with NMN (see the NAD video series). Then, one can identify if it works, or is neutral or detrimental, even at higher doses.

@birage9885 Год назад

@@conqueragingordietrying1797 Have you done that for NAC/Glycine? If so, please share results.

@denny8111 2 года назад

Which one serine or NAC? Or both?

@JohnSlack89 3 года назад

Is sugar oxidation more damaging to the body than fat oxidation? E.g. Is there more ROS generated when sugars are oxidized relative to fats? I've heard athletes can't be as explosive without glucose or glycogen stores - typically more power dense fuel is less efficient fuel (more byproducts or heat).

@conqueragingordietrying1797 3 года назад

I'm not trying to demonize sugar oxidation for energy, which has its place, including high-intensity exercise. However, we spend most of our existence burning fat. That mitochondria in older adults have worse fat oxidation, and correspondingly, try to account for it by being better at oxidizing sugar doesn't fix the problem. Note that youth is characterized by mitochondria that are better at burning fat, not glucose, and restoring GSH improved that in older adults.

@JohnSlack89 3 года назад

@@conqueragingordietrying1797 Interesting, thank you very much. Great video!

@Lucasukx 3 года назад

Excellent presentation of an amazing study! So many hallmarks of aging altered! Do you think taking liposomal glutathione would be better or worse than the Glycine + NAC combination? What might be they cause of declining Glycine and Cysteine as the years pass? Some of the improvements seemed to remain over baseline figures when the supplementation was stopped. Might that indicate a marginal long term improvement has been achieved?

@conqueragingordietrying1797 3 года назад

Thanks Luca Crane. I hope the data isn't too good to be true, as there's only 1 research group using the high dose glycine-NAC approach. In terms of that vs. liposomal GSH, I'm not sure, no studies have compared which would be better in terms of increasing systemic levels of GSH.

@powerpuffherk 3 года назад

@@conqueragingordietrying1797 What might be they cause of declining Glycine and Cysteine as the years pass?

@conqueragingordietrying1797 3 года назад

@@powerpuffherk This is speculation, but I'd bet on increased glycine conjugation, which serves as a detoxification mechanism. "Bad" metabolites in the blood increase during aging, which are then conjugated by the liver and kidney with glycine to target them for excretion. However, that limits the amount of glycine available for GSH synthesis.

@MasterArmedforces 2 года назад

@@conqueragingordietrying1797 I've been suffering and living with chemical sensitivity headaches for six or seven years now without being able to determine their root causes, or how to avoid them (other than constantly avoiding artificial odors in my day to day life). They trigger tension in the base of my rear neck, which leads to the headaches that can only be treated with hours laying down, or muscle relaxants (naproxen, ibuprofen, acetaminophen, nor aspirin make a dent in the pain). For reasons unrelated to these headaches I decided to incorporate liposomal glutathione to the three or four anti oxidants I already supplement with on a daily basis. To my surprise I realized about a week later that I had not had any headaches. I specifically realized it on an occasion where I had been exposed to an odor which had always caused me headaches in the past. I cannot wrap my head around the correlation between the glutathione and the dissipation of my headaches. I know that glutathione helps the body deal with free radicals and oxidation released by inflammation, but that doesn't help me figure it out. Can you connect these dots anywhere and see where the correlation may be? I feel that if I can figure out how these two things are related, I may be able to get to a deeper root cause. Thanks!

@nicolelaurentLMHC 2 года назад

Did they identify why the older population had less cysteine and glycine? Was it because their stomach acid is lower maybe and they don't break down protein as well into amino acids? Is it because of other micronutrient deficiencies that influence digestive enzyme production so they tend to eat less meat (e.g., zinc)?

@larsnystrom6698 Год назад

@Nicole Laurent, LMHC Most good protein sources give you perhaps 2 g of Glycine. That's not enough! Collagen has about 23% Glycine. So that's our best source of that. But you need most of it for building your own Collagen. Supplementing with Glycine is a go9d idea!

@jackbuaer3828 3 года назад

Does TMG equate to Glycine? I take 3-4 grams of that daily. I did see one study that foundTMG increases Glutathione in Rats

@conqueragingordietrying1797 3 года назад

It could act as a source of glycine, but obviously TMG is tri-methylated glycine, and would/could have other systemic effects.

@jackbuaer3828 3 года назад

@@conqueragingordietrying1797 Thanks for your response and this video!

@overlordl1 Год назад

10/10

@surfreadjumpsleep Год назад

Michael, what do you think of creatine supplementation? Doctor Brad Stanfield says that many people can benefit from supplementing with it. It's a popular supplement so I'm curious what you think.

@conqueragingordietrying1797 Год назад

There's a lot of positive data for it, it's on the short list of supplements that may actually have a benefit. For all people, though? That's a bit debatable.

@surfreadjumpsleep Год назад

@@conqueragingordietrying1797 Have you ever taken it? Is it something to take for long periods or just to sort of try to push yourself beyond a plateau of muscle performance?

@conqueragingordietrying1797 Год назад

@@surfreadjumpsleep I took it a long time ago during my gym bro years. It could be beneficial for older adults, as it can assist with the ATP-CP energy cycle. I don't see a use for it now, though.

@surfreadjumpsleep Год назад

@@conqueragingordietrying1797 I'd love to see a video from your 'gym bro' years. OK.. this bottle of creatine goes back to the store. Thank you for the guidance.

@redberries8039 3 года назад

9g per day of NAC ??? ... that's a massive dose. I take it and feel odd if I get anywhere near 1g (a sort of brittle feeling, difficult to describe) WebMD doses for all reasons go nowhere near 9g. I'd like to see a study with a lower dose.

@andrewj4426 Год назад

In rat studies high doses of NAC reduced oxidative stress etc but gave the rats lung cancer. i dismissed it because the NAc amounts were so high in comparison, but if it takes such large NAC to produce positive results the risks might not be worth it. i hate all these unrealistic dose studies.

@redberries8039 Год назад

@@andrewj4426 right, i've seen the same study. I take ~200mg late at night and that's enough to help clear out a glass of wine by morning.

@Johann_ 2 года назад

2:58 Are Glycine and Cysteine used in other reactions in older adults ? That would explain why it drops and maybe try to conteract the process in which they're involved in ? Just asking 🤔🤔

@conqueragingordietrying1797 2 года назад

Glycine is involved in detoxification reactions. So more xenobiotics-->more glycine conjugation-->potentially less glycine available for GSH synthesis.

@Johann_ 2 года назад

@@conqueragingordietrying1797 Thank you for your response! I'll dig deeper into this path then! I just watch your video on Homocysteine, very informative too!

@conqueragingordietrying1797 2 года назад

@@Johann_ Thanks Johann, and enjoy!

@Johann_ 2 года назад

@@conqueragingordietrying1797 I sure will 😉

@larsnystrom6698 Год назад

@Johann Glycine is a major part of Collagen. So, that's very likely the reason why it's to low. We doesn't eat as much Collagen as we used to. The level of Glycine they supplemented with (7 -- 8 g) is about what we could get from eating the old way. Supplementing with Collagen and especially Glycine is a good idea!

@lagianna100 3 года назад

How can we improve Glycine and NAC intake through diet?

@conqueragingordietrying1797 3 года назад

Great question. Eating more protein would be expected to increase glycine+cysteine intake, but as we all know, too much protein can shorten lifespan, at least in mice. So there's a fine line for that.

@andrewtaylor9799 2 года назад

Glycine is heavily present in animal skin, cartilage, bone...so eating a lot of chicken skin and making bone broths would be a start!

@maxmin5272 2 года назад

N-Acetyl-Cysteine NAC is technically a drug approved by the FDA. A prescription is thererore required. Question: Can N-Acetyl-L-Cysteine, a supplement, replace NAC for the same result on Glutathione levels?

@conqueragingordietrying1797 2 года назад

Hey Max, N-Acetyl-L-Cysteine = NAC. Its synonyms are on this page: hmdb.ca/metabolites/HMDB0001890

@maxmin5272 2 года назад

@@conqueragingordietrying1797 Thanks a lot Michael.

@JuneRevelations Год назад

What are the dosages and the ratios of the supplements? I somehow missed that info I guess

@conqueragingordietrying1797 Год назад

It's there, 3:07

@JuneRevelations Год назад

@@conqueragingordietrying1797 Thanks so much for helping me out! Awesome video!

@Avital4414 3 года назад

I have been taking NAC, Glycine and ALA for several years, but in much smaller doses than in these two studies. I will increase my doses, gradually. Any particular reasons to be cautious?

@conqueragingordietrying1797 3 года назад

Yes, megadosing anything is a reason for caution. Do you blood test? I'd recommend that for any supplement regime.

@Avital4414 3 года назад

@@conqueragingordietrying1797 what panels would you recommend?

@conqueragingordietrying1797 3 года назад

@@Avital4414 At least the standard chem panel + CBC, which is < $35USD. Even better is adding an inflammation--related marker like hs-CRP.

@Avital4414 3 года назад

@@conqueragingordietrying1797 I have asked my doctor to include CRP in my labs, but she resists - her rationale is that it’s too generalized a test. But my curiosity will prevail next time.

@conqueragingordietrying1797 3 года назад

@@Avital4414 I only get my blood tests done with my GP 1x/year. I order the tests online, and then go to Labcorp, which draws my blood and does the analysis. If you're in the US, I'd recommend that to get around having to ask your Dr for permission, which is absurd.

@NoneOfTheAboveEntParty 3 года назад

How do they get that much NAC in without side effects? I've read other places that supplementing more than 1200mg leads to some unhappy side effects.

@kkostadinof 3 года назад

Yes, PAH is a real concern at high NAC dosing - so I'd max at 1800mg /d and glycine at 5g/d and be done with it. If it helps, it helps, if it's insufficient, so be it.

@jackbuaer3828 3 года назад

@@kkostadinof According to Life Extension Foundation, the 2007 study that found NAC caused PAH in mice used the human equivalent of 20 grams a day. The 2010 LEF article also indicated they found no other evidence of NAC causing PAH and they questioned the findings of the 2007 study. Nevertheless, I think will try the 1800 mg strategy.

@NoneOfTheAboveEntParty 3 года назад

@@kkostadinof What is PAH?

@kkostadinof 3 года назад

@@NoneOfTheAboveEntParty Pulmonary arterial hypertension

@TheReminderChannnel 3 года назад

Does anyone know if there’s any other things that need to be taken whilst taking NAC and glycine? I mean do they deplete other nutrients etc.? eg b-vitamins etc 🤷‍♂️

@conqueragingordietrying1797 3 года назад

Probably the best way to answer that is comprehensive blood testing.

@TheReminderChannnel 3 года назад

@@conqueragingordietrying1797 good point 🙈, thank you 🙏 I just remember reading somewhere a while back that it was imperative to take certain supplements to aid NAC, just can’t remember where I read it 🤦‍♂️

@TheReminderChannnel 3 года назад

@@conqueragingordietrying1797 are you taking glycine and NAC as suggested in the above study? If so, do you feel any benefits?

@conqueragingordietrying1797 3 года назад

@@TheReminderChannnel I'm not-my insulin sensitivity (insulin, glucose) and inflammation (hs-CRP) markers are usually pretty good, so I don't have the need to boost GSH, which would be expected to impact those variables. However, if my approach stops working because of age, it's good to know that boosting GSH, as shown in the video, may help.

@TheReminderChannnel 3 года назад

@@conqueragingordietrying1797 oh ok, thank you for the concise, clear and prompt explanation, genuinely much appreciated 🙏

@surfreadjumpsleep 3 года назад

So does this mean Dr. Lustgarten will be starting to supplement? I don't think you can get 9g of NAC from carrots, or? BTW, had you seen this? some issues with blood pressure & NAC: www.sciencedaily.com/releases/2007/09/070904175353.htm Wish they would have done some epigenetic tests along with that. There ought to be a "we'll fund your epigenetic testing add on for your study" pool of money that researchers could draw on.

@conqueragingordietrying1797 3 года назад

Ha, I'm not anti-supplementation, but I favor targeted supplementation when there is a need. Inflammation and insulin resistance increase during aging, whereas GSH declines, and if I can't reverse that with diet, exercise, etc, then I may take glycine+NAC! Someone brought that article up earlier today, but there's also this: insight.jci.org/articles/view/127647

@surfreadjumpsleep 3 года назад

@@conqueragingordietrying1797 Hopefully they'll do another study determine a dose response relationship. lung cancer does not sound great, but only in 10% of normal mice.

@johnb9942 3 года назад

@@surfreadjumpsleep Only 10% is 100% if you are the one that gets the lung cancer. I'm worried about this. I think I will wait before taking these large amounts.

@surfreadjumpsleep 3 года назад

@@johnb9942 definitely more studies are required. My cousin's wife is a doctor in Boston who is running a trial to determine if short term high dose NAC helps fight serious covid-19.

@surfreadjumpsleep 3 года назад

@@johnb9942 I agree. Certainly more trials are needed in people. It would be good to read this trial and see what sort of other biomarkers they tracked.

@agaragar21 2 года назад

Took some NAC and now I'm in a wheel chair from crippling arthritis..................thanks RU-vid!

@conqueragingordietrying1797 2 года назад

In the video, I didn't recommend NAC supplementation (that's up to you, or not!). I just reported what the studies found.

@fedes9626 2 года назад

I did this calculation but I am not sure where I am doing it wrong 1.33 mmol for glyscine, if the molecular weight of glycine is 75.067 g / mol then (1.33 mol / 1000) * 75.067 g/mol = 0.0.9983911 g per kg so 0.01 g per kg, could you explain please how did you arrive to 0.1 g per kg? Thank you

@fedes9626 2 года назад

My bad I rounded up without moving the decimal coma, silly me.

@conqueragingordietrying1797 2 года назад

Sure fede san, no worries. It's 1.3 mmol (millimolar), not 1.33 mol-that's the discrepancy. 1.3 mmol = 0.00133 mol, then multiply by 75.067 g/mol, which = 0.1mol/kg for glycine.