Professional antigen presenting cells (APC) and MHC II complexes | NCLEX-RN | Khan Academy

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How professional antigen presenting cells present parts of engulfed pathogens on MHC II complexes. Created by Sal Khan.
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17 фев 2010

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Комментарии : 146

@patt0305 11 лет назад

I can honestly say, You are the reason why I got into pharmacy school. Thanks! Now you are getting me through my first year!

@Emoney131 11 месяцев назад

are you a pharmacist now?!?

@shadiyabegum6491 8 лет назад

i wish all the videos were numbered its so annoying when i miss a part .

@jasonnewport3120 7 лет назад

They do have a website and they are in order. www.khanacademy.org/science/health-and-medicine/human-anatomy-and-physiology/introduction-to-immunology/v/professional-antigen-presenting-cells-apc-and-mhc-ii-complexes

@shadiyabegum6491 7 лет назад

Jason Newport hey tankx a lot ;) its million times easier now

@sharonhammond7471 11 лет назад

I love Khan Academy! It's taken me through two semesters of A&P I and II and Microbiology as well as Chemistry!

@user-sg5jq3ig4k 9 лет назад

Thank you very much indeed. I have tried many video presentations all with no exception are too long, too detailed and so confusing. Yours are pleasant, full of good humor and give a sound background for further deepening in one subject or another. These beautiful video are no less than true masterpiece!

@fleshcookie 11 лет назад

Sal slays me. "Professional, so this is what they do for a living!" lol

@foundfavor09 9 лет назад

After watching your video you made the reading in my text more clear. Thank you.

@SeichoBlossom 9 лет назад

Sal you're the greatest, you know this already. Your videos got me thru chemistry, A&P, and microbiology. (:

@RK-qp4br 6 лет назад

Absolutely outstanding. This should be a must for every medical student, resident, fellow and faculty.

@MarcoPolo057 4 года назад

Dude.. You just taught me a whole semester in One day.. Much obliged

@LilyInCanada 5 лет назад

Your biology videos make me understand much more than my textbook. Thank you.

@Nicker000 4 года назад

thanks, good reference brush-up in time of need.

@chamich24 10 лет назад

Thank you so much for all of your videos. The illustrations really help!

@robert2241 9 лет назад

Khan academy's lessons R perfect for students all ages

@lazonda 11 лет назад

I love this stuff! And YOU, my intelligent one, are AMAZING. Thanks for all your hard work and please continue.

@krmanjahmad659 4 года назад

یەکێک لە هەرە باشترین ڤیدیۆ ڕونکراوەکانی بایۆلۆجی بەڕاستی لە وانە وتنەوەکەت تێئەگەم one of the best explanation vedios of biology i really get understood of your lecturing

@marianoh44 11 лет назад

awesome video, clears up pretty much all my questions, now on to the next video

@sweethomerezervation3768 8 лет назад

Thank you for this video! It's beneficial!

@imtithalalkabee1305 Год назад

it is been 7 years i'm watching your videos and now i'm in Pharmacy school and still watching your videos . thank you so much you help me a lot.

@ohyeabananas 11 лет назад

This is so much more exciting and entertaining than my AP Bio class... thanks, its good review!

@cristianerazovilla5770 11 лет назад

You need to keep doing more videos please! you're awesome !!!

@OxAxS 12 лет назад

Beautiful clear explanation. Will use the info I get from this for our group PBL tomorrow.

@TheCakeWizardGuy 11 лет назад

Downloading Knowledge - download complete. Thanks for these videos, makes everything a lot more clearer than any book could try to do! :)

@solianalovesfrogs8357 4 года назад

you are amazing! thanks for the great, fun and easy to understand explanation

@paaojipop 9 лет назад

thank you so much !!! you made me more understand about MHCs. i will watch others video of yours. :)

@tenzinlhakyi6610 Год назад

always saves me. Thanx for this wonderful tutorial.

@elysegarrison 9 лет назад

thank you so much for your videos. They have been a god-send

@margotgabrielefalcone6106 11 лет назад

really clear indeed! u are my idol!

@thegreatMSG 10 лет назад

Thank you so much!

@therealmunkyhaus 14 лет назад

BRILLIANT ! thank you

@latikalula2896 9 лет назад

thank you soooooooooo much.. am a medical student 3rd year now.. u saved my day

@pumpkins5390 3 года назад

Story of my life

@emynoack7344 Год назад

Wonderful explanation. Thank you.

@KinesioNeuroHealth 13 лет назад

thanks for helping me study for neuro/chem/immunology

@ryanasgalbraith7824 11 лет назад

My exam is tomorrow, and thanks to this video I finally fucking understand MHCs. Why couldn't I have discovered this channel sooner?!

@seaweedcat4267 5 лет назад

"Hey, you're a bacteria, I don't know what kind you are, I'm just gonna eat you up, you look shady, I don't know what type you are or if I've seen you before."

@sharedivinelove 13 лет назад

Thanks again. U r awesome. God bless U!

@aspirezakura 13 лет назад

So, soooo good. Thanks for helping my fellow slacker medics and I.

@manalabushadi8050 6 лет назад

Thank you so much ✨

@manjushreeinamdar1242 4 года назад

You are brilliant. Thankyou for helpin us

@Grimething 9 лет назад

You look shady :,D gets me everytime

@dhruvk7892 8 лет назад

Thanku sir. U r great

@fang2111 10 лет назад

Hi! Could u do a video on priming of T and B cells, or cross-presentation by Dendritic cells?

@brittanyjacobson5199 3 года назад

very nice, thanks so much

@hendashraf833 7 лет назад

Thank you thank you so much sir .. you are the BEST

@luckydesilva6733 3 года назад

Thank you so much.

@zigzagline1 10 лет назад

Thank you for posting this video.. Excellent

@pajeshjp9087 5 лет назад

Very clear

@AussieStormbuddy 14 лет назад

Yay for APC's!

@kamstergtohello 13 лет назад

Very very helpful!!!!

@noumed10 11 лет назад

Thank youuuuuuuuuuuuuuuuuuuuuu..You're just fascinating

@luv4pupies 13 лет назад

Thanks alot, it is really helpful^^

@nazlimcfian 5 лет назад

i feel so lucky to find this video ! who would have known! a video shared 9 years ago would save immunology grades of a dental student >.< ahaha thank you so much sir.

@chaimabeens Год назад

u r the reason why i'll be meeting the president for getting the highest marks in my Baccalaureat exam:)

@meeker1021 11 лет назад

thank you so much for your help. my teacher could not get through to me...why? thick accent...yours: perfect!

@tranle92 11 лет назад

best explanation!!!!!

@sofiaarias13 14 лет назад

thank you!! NICE

@abdisalamelmi5075 10 лет назад

Thanks much more.

@rachrachel1 12 лет назад

can you teach my teacher for immunobiology how to explain so good these stuff?? thank you so much great help!

@ashishtewari01 12 лет назад

This is what they do for a living :D awesome man,,,..... i am still smiling :)

@cwaddle 12 лет назад

Amazing video. Having 0 Dislike is a testament to your video

@Mightymumble 11 лет назад

You are amazing!

@hostagelai 13 лет назад

AWESOME!!

@EckosamaGhostTsushima 14 лет назад

I know, I was like, man I wish he did other stuff (that I learn for my major) besides chemistry. Then I saw this, and I was like, goodie!, I'm taking immunology right now.

@TheNeverborn 12 лет назад

@pyromanizak The short answer is yes. Each B cell gets a unique antibody during it's growth, but you have so many B cells that eventually the viruses run into one with antibodies that work. That B cell begins dividing, but its daughter cells have a high rate of mutation for the antibody tips. Since they're all in competition with each other for antigen, the ones that bind better keep reproducing, and the ones that bind worse die. So eventually you get a very good antibody for the antigen.

@elkozako12 10 лет назад

I am in nursing school. God Bless you for these videos. My book is like foreign language. Finals in 2 days.

@taiyesamuel5618 2 года назад

Thank u khan academy

@shreygarg3755 9 лет назад

thank u

@imegatrone 12 лет назад

Nice Video That You Share , So Very Nice Thanks You How professional antigen presenting cells present parts of engulfed pathogens on MHC II complexes

@NK32202 11 лет назад

Does he explain NK cells in any of the videos?

@migwke1 12 лет назад

Im a little confused as to what happens after the macrophage presents the polypeptide on the MHC II complex. Who is it presenting it to?

@bushrax9 12 лет назад

i was wondering what program was used in this explanation ?

@geepeeone 12 лет назад

@akored23 The antigen-immunoglobulin complex has to be endocytosed first then presented along with the MHCII complex has to happen first so that the T-helper cells with the same immunogenic specificity are able to bind with the said B-cells, which results in B-cells' activation, then monoclonal proliferation with some turning into Plasma cells, while others into Memory cells,.

@BikRunGirl81 9 лет назад

wait, does b stand for bursa? lol... love your videos they are a lifesaver!

@ichigo9919 8 лет назад

So Dendritics, macrophages ect. are like the Dexter of the cell world

@mahadshakil5356 5 лет назад

I understood that reference :3

@youtubec8563 5 лет назад

Up to 4:15, it's review from previous video the nonspecific response.

@youtubec8563 5 лет назад

Up to 7:35 it's a review from the B cell video

@youtubec8563 5 лет назад

Watch up to 0:05 review of B cell, but more importantly compare the similarity of B cell and MHCs (they both present pathogen's on the membrane)

@hadiloo1 11 лет назад

I LuuuV youuuu !!! thankssssssssssssss

@2rki1 4 года назад

Is dendritic and macrophages consider professional APC’s then??

@sabrinagunawan6170 9 лет назад

So basically both phagocytes (macrophages, etc) and most of the B-cells don't know whether the antigen is the enemy - they just combine, cut up and present the antigen, with the difference between them being that phagocytes can engulf any cells while B-cells can only engulf one specific type of cell? And then that's where the T-cells come in, so that they can recognize and then stimulate? I'm sorry, Biology's not really my forte, so I'd be grateful if anyone can clarify on this :)

@jamesrichard1140 9 лет назад

Does this mean a Bcell is phagocyte if it actually engulfs the antigen and presents it on its surface?

@sabrinagunawan6170 9 лет назад

james fancourt No, a B-cell is not a phagocyte even if it engulfs the antigen and presents it. The habit of presenting the antigen is just something that the two of them have in common. Their reactions are different: phagocytes will do the 'destroying' of the foreign pathogens, while B-cells will develop and produce a lot of antibodies which will guide the phagocytes and let them know which cell is the enemy, so that the phagocytes can engulf them. The part where they present the antigen is only a common thing, and that is basically to stimulate the T-cells. (T-cells, as the guy in the video said, will decide whether it's dangerous or not, and will then 'sound the alarm'. It is, basically, the immune system's alarm) :)

@jamesrichard1140 9 лет назад

constellations of books wow thanks a lot! Really helped

@sabrinagunawan6170 9 лет назад

james fancourt oh hey, thats awesome, you're welcome :D

@jeffjohn3870 6 лет назад

thank you

@markfalina9160 5 лет назад

Sal, don't you think it's kind of important to go into a little bit of how the macrophage knows the item it "eats" is unwanted? Maybe a macrophage bumps into a red blood cell. How does it know not to "eat" it?

@theWellSeasonedWoman 10 лет назад

are there amateur antigen presenting cells? sorry, couldn't resist...

@Reglage 9 лет назад

theWellSeasonedWoman T cells can present, when activated, antigens on their cell surface (has been shown in literature). These T cells however are not as able to stimulate other T cells and to process antigens in the efficient manner as the 'professional' APCs can and do. This is also the case for for example fibroblasts and endocytes. When these types of cell gets activated by cytokines (mainly IFNg), they acquire the ability to present ligands.

@theWellSeasonedWoman 9 лет назад

CubicRegje you may be accurate, but no fun at all!

@NoName-qt4tt 5 лет назад

When APC presents antigen on MHC CLASS 2 then after production of antibodies what will happen with antigens on MHC?

@pinoycharms5077 10 лет назад

Why is it in slow motion?..please fix it..it really helps me a lot

@Destroyer9623 11 лет назад

Macrophages have invariable receptors and cannot recognize all pathogens, they can only recognize a small subset of similar pathogens.

@LovelyMetalAmanda 11 лет назад

@vrwhitlockable the B cells were non specific.

@rachelj59 8 лет назад

I thought it was only macrophages and neutrophils that were phagocytic. Does this mean that dendritic cells and B cells are phagocytic too? Thanks :)

@slaydrian3024 8 лет назад

+Rachel J macrophages, neutrophils, and dendritic cells (all phagocytes) perform phagocytosis, B cells are immune cells that pretty much identifies them for the phagocytes to engulf!

@ossmbc 11 лет назад

is the adaptive immune system in human body only ?? or in mammals and animal kingdom as well ?

@nima4719 5 лет назад

Little bit of original pathogen on APC??

@taiyesamuel5618 2 года назад

Still here in 2022 🙏🏻🙏🏻❤

@dhevannrajramalingam4163 9 лет назад

Will the plasma and the memory cells have the MHC type 2 as well ?

@moemad001 9 лет назад

Dhevannraj Ramalingam No. All nucleated cells and Platelets have MHC class 1. Only APCs have MHC class 2

@kanchanshinde6887 4 года назад

your voice is like mr.bean in hindi series !

@hooiyuanteng 12 лет назад

I like your videos... ^^

@Beautylicionista 11 лет назад

Hey it's actually "TI", major histocompatibility complexes!!!

@ivancharm 13 лет назад

OMG....you are the GOD man !

@mikecastro4403 4 года назад

Wow 8 years ago

@fredd298 12 лет назад

are these DNA shufflings random? Meaning if a few people happened to have a immunity to a new virus it is a stroke of luck that their b-cells happened to have made the correct antibody?

@banannarama27 12 лет назад

Ha! 293 likes and no dislikes. That's fantastic.

@rico1660 8 лет назад

so APC's and MHC II are both still apart of the innate nonspecific response?

@yerinpark1610 8 лет назад

yes

@delyankyupribashiev6381 4 года назад

you are life

@rukado 10 лет назад

You really can make this stop looking like chinese to me. I dont know how you can draw so well with your mouse. Thank you very much!

@sesamesprite986 8 лет назад

+rukado i think he uses a drawing pad

@sadafshefa2285 5 лет назад

What I don’t like about khanacademy videos is that they simplify the concept way too much that it gets confusing. I’d really appreciate it if they used more scientific words or would not talk too much around the topic.