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1:21 Prostate cancer in 2024
2:26 Problems with current techniques
2:47 Prostate Specific Antigen (PSA) 1987
4:20 1-2 million men have undergone treatment that probably didn't need it
4:48 SPCG-4, PIVOT and ProtecT Trial - Sharks and Minnows
6:49 Digital Rectal Exam (DRE)
7:30 TRUS Guided Biopsies
11:13 Prostate cancer is the only major solid organ malignancy not routinely imaged
11:48 Prostate cancer is blind
12:04 Clinically significant prostate cancer
12:27 Magnetic Resonance Imaging (MRI)
15:17 Multi-parametric MRI of the prostate
16:00 PSMA PET vs mpMRI - PCa detection
16:39 MRI shapes and margins: Peripheral/Transition Zone
17:27 Diffusion imaging correlates with Gleason score
18:15 PIRAD score for MRI's
20:21 MR guided biopsy and treatment
21:13 MRI guided biopsy
22:20 Transperineal US PSMA PET fusion biopsy
23:25 Regional targeted biopsy
24:56 UCLA Integrated Idx biopsy report
25:50 MRI detects up to 90% of csPCa
26:27 Randomized controlled trials
27:24 MRI and PSMA PET CTRI
28:02 Indications for Prostate MRI
28:29 Prostate MRI: Active Surveillance for the minnows
30:15 MRI improves surgical planning for sharks
31:10 MRI DTI can show nerves
31:28 MRI-visibility and outcomes after Prostatectomy
33:05 Radiation planning: MRI + PET
34:22 Artificial Intelligence for Prostate Cancer Diagnoses
35:33 MRI helps improve Genomic tests and MRI visible tumors
36:10 MRI improves performance of Oncotype, Decipher tests
37:33 MRI and 4K tests are additive
37:44 MRI improves urinary PCA 3 prediction of high grade PCa
38:14 Genomics may influence MRI visibility of Pca
38:38 MRI radiogenomics
38:56 Nimbosus: Co-Occuring aggressive features
39:56 MRI visible tumors genetically enriched with unfavorable PCa features
40:30 MRI visible lesions have aggressive protein structures
41:34 PI-RADS score and outcomes after radiation therapy
42:17 MRI is critical for personalized medicine at work
42:55 Summary
44:40 Dr. Mark Moyad Q & A
51:02 What is the best tool we can adopt into prostate?
53:13 Will we get to the point where we can diagnose prostate cancer without a biopsy?
55:30 Interventional radiology
58:20 Open vs closed MRI
1:00:41 Do you need a 3T level MRI or 1.5T?
1:02:24 Can you get an MRI with metal in the body?
1:06:38 What does in bore/fusion biopsy mean?
1:09:19 Should everyone get an in-bore biopsy?
1:14:28 How long do you wait for an MRI if there has been trauma to the prostate?
1:16:10 Does experience reading the MRI make a large difference?
1:19:03 What about second opinions?
1:22:31 Why do MRI's miss 20%
1:26:03 Combining MRI with PET scan
1:27:17 With an MRI do you use contrast (Gadolinium) or not?
1:34:56 What about diet restrictions with imaging
1:37:24 Is MRI sensitive and accurate in measuring prostate size?
1:41:56 Pros and cons about MRI combined with PET scan
1:45:15 Different types of PET CT scan
1:48:16 SUV & PET/CT scan
1:50:36 PET/CT scan false positives and/or false negatives
1:55:35 Are more cancers caught as a result of increasing velocity?
1:56:46 PSMA predictability
2:01:10 PSA fluctuation - PSMA used for confirmation?
2:03:26 What is better for screening - MRI or PSMA PET?
2:04:02 Better for active surveillance - MRI or PSMA PET?
2:04:57 Better for rising PSA after treatment - MRI or PSMA PET?
2:05:16 Better for no PSA after treatment means no cancer - MRI or PSMA PET?
2:05:37 What is better for rising PSA with ADT - MRI or PSMA PET?
2:05:56 Impact pf PSMA PET on prostate cancer management
2:07:40 What makes you a good candidate using PSMA for radioligand therapy?
2:10:38 What about Halo artifacts on a PSMA PET CT scan?
2:11:59 With a PSA of 0.5 or higher and no evidence of tumor - repeat MRI or PSMA?
2:13:00 Where is the best use of resources for study - MRI or PET scan?
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The Prostate Cancer Research Institute (PCRI) is a 501(c)(3) not-for-profit organization that is dedicated to helping you research your treatment options. We understand that you have many questions, and we can help you find the answers that are specific to your case. All of our resources are designed by a multidisciplinary team of advocates and expert physicians for patients. We believe that by educating yourself about the disease, you will have more productive interactions with your medical professionals and receive better-individualized care. Feel free to explore our website at pcri.org or contact our free helpline with any questions that you have at pcri.org/helpline. Our Federal Tax ID # is 95-4617875 and qualifies for maximum charitable gift deductions by individual donors.
4 май 2024
