mist trance is a pretty well rounded defensive spell that give cooldown reduction, combo setups and a ton of mobility. Honestly it can be played effectively with anything right now. A spell that especially takes advantage of it though is soulburn since the teleport is very useful and getting cooldown resets on soulburn is amazing.
This build is better at long range and more mobile. Aegis lance on the other hand is significantly more damage, has an easier time forcing its combos but is weak if it cannot find a way to get in melee range for fears. Overall aegis lance is much easier to play and stronger but this versions playstyle is a lot more standard and is really good if you manage to play a fight perfectly
Some ppl play with their keyboards turned at an extremely aggressive angle (the arrow keys close to chest and esc key away from you) and you can rest your palm on the space bar, thumb on l/k area. It takes getting used to but I find myself playing with my keyboard turned aggressively, I don't need to use l/k because of mouse side buttons however.