it is hard to separate OP-ness from specifically "hard to kill"... so, this might not be the best list, but here's some others: (not ranked, just list) 1. Guts in Berserk 2. Alucard in Hellsing Ultimate (and the really old school Hellsing too) 3. Saya in Blood+ (and the krappy off-shoot of the "Saya Saga": Blood C) 4. Teresa of the Faint Smile in Claymore 5. Awakened Priscilla in Claymore 6. Tatsuya in The Irregular at Magic High School 7. Motoko Kusanagi in Ghost in the Shell: Stand Alone Complex 8. Medaka Kurokami in Medaka Box 9. Kumagawa in Medaka Box 10. Najimi Ajimu in Medaka Box 11. Lihiko Shishime in Medaka Box 12. Sagara in Full Metal Panic 13. Heero Yuy in Mobile Suit Gundam Wing 14. Mileardo Peacecraft in Mobile Suit Gundam Wing 15. Treize Kushranada in Mobile Suit Gundam Wing 16. Yujiro Hanma in Grappler Baki and the new "Baki" seasons 17. Violet Evergarden in Violet Evergarden 18. Abel Nightroad in Trinity Blood 19. Cain Knightlord in Trinity Blood 20. Goblin Slayer in Goblin Slayer 21. Kurumi in Date A Live 22. Kaede ("Lucy") in Elfen Lied 23. Hei in Darker Than Black 24. Alphard Alshua in Canaan 25. Vash the Stampede in Trigun 26. Spike in Cowboy Bebop 27. Dante in Devil May Cry (yes, there's an anime of DMC, lol) 28. Moka Akashiya (the real/true/inner/vampire Moka) in Rosario+Vampire 29. Alucard in Rosario+Vampire 30. Sara in Samurai Champloo 31. Balsa in Moribito: Guardian of the Sacred Spirit 32. "Elen/Eren" ("Ein" = 1 in german) in Phantom: Requiem for the Phantom 33. Reiji ("Zwei" = 2 in german) in Phantom: Requiem for the Phantom 34. Cal Devons ("Drei" = 3 in german) in Phantom: Requiem for the Phantom 35. kenshin in Rurouni Kenshin 36. Shishio in Rurouni Kenshin 37. Kenshin's sensei/master/teacher in Rurouni Kenshin (can never remember his name, too lazy to look up) 38. Ban in Seven Deadly Sins 39. Rushuna Tendo in Grenadier: The Smiling Senshi 40. Masane Amaha in Witchblade 41. Angel as Big Venus in The Big O 42. Solty Rei in Solty Rei 43. Mr. Chang in Black Lagoon 44. Balalaika in Black Lagoon 45. Rosarita ("Roberta") Cisneros the Blood Hound in Black Lagoon 46. "The Great" Rebecca ("Revy") Lee "Two Hands" in Black Lagoon 47. Dutch in Black Lagoon 48. Medusa Gorgon in Soul Eater (somewhat similar to Orochimaru in Naruto, as both have serpent powers, lol) 49. Lord Death in Soul Eater 50. Thor in Jyu Oh Sei: Planet of the Beast King and more... listing too many MCs of animes.... already, sighs... lol
