i dont mean to be off topic but does someone know a tool to log back into an Instagram account..? I stupidly forgot my password. I would love any help you can offer me
@Kyrie Dustin Thanks so much for your reply. I found the site on google and Im trying it out atm. Looks like it's gonna take quite some time so I will reply here later when my account password hopefully is recovered.
soo helpful i just want to ask a stupid question each tyrosine phosphorylate the other one that is in front of it right? why do we use 6ATP molecules, why not just 3?
So, RTKs are encoded by many genes in our DNA. That means we have different subfamilies (they contain different numbers of tyrosine residues in the cytosolic part -> in the video I drew just 6 but it can be even more). So depending on the subfamily of the RTK much more Phosphates can bind to the cytosolic part. To your question now: In theory 2 would be enough, right. But over the evolution, it one can speculate that it was advantageous for the genes to carry more tyrosine domains (it might be that cells and by that even animals with more domains had a selective advantage over cells with fewer phosphate binding RTKs (but since it is evolution, this is just speculation)
I think you can also add that cell reception typically amplifies the response, this is advantageous for stuff like hormones, at the end of the day if your pituitary gland releases lets say 1000 molecules of ADH (again the number is small for simplicity sake, your gland would release millions of these) there is no way to know how many of them would actually bind to the nephrons in your kidney, however we still need to produce an adequately large response therefore the ability of a single ligand to cause a lot of intracellular change is desired, this increases the efficiency as less ligand needs to be manufactured. Does that make sense?
