I have been watching your videos all semester long and I appreciate your lectures very much, so thank you. I do have a question, if you have the time and please correct me if I'm wrong. I a visual person so I have to draw these thing out sometimes. My questions is, is your arrow from ADP ⤸ ATP on the left between the R-States flipped? Shouldn't it be going in the the opposite direction pointing up, so ADP is coming out toward both of the Phosphorylase a? Thank you for your help.
He's showing that the above R-state can be de-phosphorylised into the below R-state, and so an ADP is gaining a phosphoryl group to become ATP. Basically the opposite of what's happening between the two T-states.
Muscle glycogen is stored differently than liver glycogen. Sugars from starches like a white potato are stored in the muscles while fructose from fruit and high fructose corn syrup are stored in the liver.
Thank you! What factors (other than epinephrine) might activate / inactivate phosphorylase kinase? Is there any pathology that might lead to inactivation?
