Basically, you're lectures will most likely help me become a doctor. When that happens and if you're still around, I'm making a fat donation! You are literally a dream maker!
Oy my God this guy teaches way better than any lecturer l have. He is a superstar and worth donating to. Keep it up once l am done with my school l must will for sure donate
I love your videos!!! It is the most clear explanation of biochem I have ever seen. I have been staring at the book for hours, and went to my prof's office many times and got nothing. I feel it's such a waste of money and time to go a university while better teachers are out there teach for free or with much lower cost. Stupid outdated and rigid education system
Would the free glucose that was released from it's alpha 1,6- glycobond not just be exported straight out of the liver? Or is this model representative of muscle cells? Thanks for the videos. Very concise and efficient
So in both the glycogenesis and glycogenolysis videos, you said that the phosphoryl group is essentially moved from carbon 1 to carbon 6. Is it because the phosphoryl group always starts at carbon 1 relative to the oxygen?
Hi your way of teaching is excellent but in this lecture i have 2 questions 1st is that is the degradation of glycogen is started only at the alpha 1-6 chain or it is also occured at alpha 1-4 chain at same time? 2nd glucose is converted to glucose 6 phosphate by any cell to capture it inside cell and to prevent from escaping. in third step glucose 6 phosphate is synthesised now can u explain me that how it is transported to other cells from liver. How could it escaped out from liver cell when in form of glucose 6 phosphate
At the first I will thank you so much for this encrideble explanation and for your time which u spend to explain these lectures❤❤❤ but I have a question is the transferase and alpha1,4-glucosidase the same thing with the debranching enzyme??? #aklectures
Thank you a lot! I think there should be an H2O in the reaction that is catalyzed by alpha-1,6-glucosidase, when a glucose molecule is released. :) The remaining glycogen + H2O ---(alpha-1,6-glucosidase)--> glucose + The remaining glycogen
hexokinase (so far what ive learned) only plays a part in a specific step in glycolysis. Hexokinase doesnt really form G6P, its just an enzyme that does a job in a particular way, meaning u shouldnt see it as hexokinase forms G6P, its more liek what hexokinase does to glucose forms G6P. There are multiple pathways to creating G6P and degradation of glycogen bypasses the need for hexokinase because another mecanism is used instead- as explained in this video. During glycolysis, hexokinase takes glucose and phosphorylates it into G6P by adding a phosphate group at the 6th carbon on glucose. This reaction seen in this video, however, doesnt start with glucose, it starts with glycogen. So theres no need for hexokinase because theres already a phosphate group on the glucose 1 phosphate sugar, only it is on carbon 1 and not carbon 6, which is why the whole 3rd step in the video transforms G1P into G6P. Basically, this process is different because glucose is a 6-carbon sugar without phosphate group, whereas in this situation *glycogen phosphorylate* will be adding a phosphate group to the glucose that was cleaved from the alpha 1-4 glycosidic bond, creating G1P. Hexokinase cant rlly work with G1P (in this context), only with glucose. hope this helps whoevers having the same question :)
Why does hexokinase form glucose-1-phosphate just so phophoglucomutase can convert it to glucose-6-phosphate from the α(1-->6) cleaved glucose by α(1-->6) glucosidase? Wouldn't it be more efficient if hexokinase just forms the glucose-6-phosphate just like it does in glycolysis?
I was wondering the same thing. Hopefully some magical person comes and explains. If you have an idea why since you made this comment 3months ago, I'd appreciate the answer...though when I come to think of it I'll probably not need the info once today's exam is done, hahaha.
they have different function dear ….. hexokinase is convert glucose to glucose -6-phosphate by using ATP but the function of phosphoglucomutase just transfer p group fromone side to another in the same molecule و الله أعلم
And also glycogen is broken down to provide glucose so if we produce glucose 6 phosphate in third step how it converted in to glucose as we mention conversion of glucose to glucose 6 phosphate as irreversible reaction
Andrei Munteanu if glucose 6 P is in muscle cells how could glucose 6 phosphatase of liver will reverse it as glucose 6 P form is only present inside cells so they can't escape out
Ehsan Humayun Yes, there is no g-6-phosphatase in the muscle cell, and in fact muscle cells don't have the ability to rise the blood sugar level unless g-6-p undergoes anerobic glycolysis, gets transformed into lactate that travels to the liver or the kidneys where it becomes glucose by GNG.
