I'm in the US and have PPMS. I appreciate the research being done but it's so frustrating. I've had MS for 26 years, have used a wheelchair for 26 years and wasn't able to do anything physical with my son. Now I have grandkids(I'm 50) and hope remyelination is something that happens in the near future.
Ugghhh, I have hope and I am super optimistic that this will happen but it just takes too long. If the government on both sides of the pond can fast track vaccinations and antivirals for Covid, it just seems like they could make an exception for certain diseases as well. 🤷🏻♀️ Just my opinion. Great video and keep bringing us great content. 🧡
PPMS for 13 years, I listened to my body and have intermittently fasted for longer than that. My friends told me it was so very unhealthy. Seems that if we listen, we have some of these answers within.
The trail ended late 2023 so it will be a bit longer. There is a view that it can promote remyelination. But with many big BUTs. It is an anti-histamine that is longer used because of its side-effects. One of them is tiredness. The trial used it in the highest allowable dose so I am not sure how much that affects MS fatigue. For example. When the results are published expect a small fanfare if they are positive.
I've had PPMS since Augest 2016 when I turned 43. Luckily I still walk without a cane, but I'm getting worse. Ocrevus has slowed it down, but I'm very eager for remyelination, oligodendrocyte regeneration, and axonal regeneration. It's good to hear the clemastine/metformin research is continuing. Thank you for that. Do you think a low carb or no carb diet, such as keto or carnivore, would yield the same results as taking metformin?
I’d check clinicaltrials.gov as anything is referenced there. Also googling around Will Brown, Clemastine, Cambridge, remyelination ought to throw up the latest news.
It is exciting to repurpose well-known drugs with known side effect profiles. Although I recognize the need to wait until the results here have been published and potentially replicated in a phase 3 trial, a problem is that clemastine has been taken off the market in several European countries. Is there a solution to this? Are there any other drugs that could be repurposed that could have the same effect as clemastine without excessive sleepiness as a side effect? Secondly, how would this work if effective and implemented? Would we stay on metformin+clemastine (or similar profile drugs) for an open-ended period of time? Thank you!
Great questions. I wish I knew the answers but I’m not a doctor. You’ll find Will’s email on any paper he is an author of reference on. He is best placed to answer these questions.
remyelination will never happen. Rather than wait for 10 years, I would rather commit suicide than live in fear of being disabled. THIS CANNOT BE JUSTICE!!!
I don’t know why you say this. All the reasonable evidence points to more than one therapy being available in a 10y window. As Dr Brown say in the video. I have lived with the fear of becoming disabled for 28y now. I intervene with the best DMT i can, exercise, sleep and a reasonable lifestyle. Working so far.
@@theMSguide We are in 2022 and you say that medicine has developed, there are still treatments according to your taste, continue to bullshit as long as there is no remyelination
No need to swear at me nor level accusations. I appreciate how frustrating MS is - having had it for so long myself - but I look at it like this: when I was diagnosed there were no DMTs and today there are nearing 20. I am on a trial for a period over adjunct therapy. Things move on, slowly.
I think you ought to share your feelings with a professional. If you are in the UK you can call the Samaritans on 116 123 or go to samaritans.org from anywhere in the world.
