TIMESTAMPS 00:00 Introductions and talk overview 02:20 Learing objectives 03:05 What is target validation? 03:34 What is Open Targets? 05:10 What are orphan drugs? 06:49 How are the DDD project, DICIPHER database and DDG2P database related? 08:05 Motivation behind the repurposing drugs for rare disease algorithm. 10:48 Method 13:55 Results 16:30 Analysis of data 19:49 Real world example 1 - Penttinen-type premature aging syndrome 20:31 Real world example 2 - Hyperkalaemic periodic paralysis type 1 22:38 Real world example 3 - CLOVES 25:03 The future of repurposing dugs for rare disease 26:34 Acknowledgements and wrap up 28:00 Q&A