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RESVERATROL & David Sinclair: Shocking Detail and Big Mistake - episode 1

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Resveratrol.
A molecule. A supplement. Resveratrol, popularized by Dr. David Sinclair, is one of the most controversial yet fascinating supplements and molecules for longevity and health.
This is the thing providing red wine its supposed health benefits.
Is it truly so? Or is the supplement a hoax?
It’s a serious question that could impact our long-term health, longevity, and our pockets - especially if we reach the wrong conclusions.
This series investigates whether Dr. David Sinclair’s conclusions on resveratrol were wrong, whether resveratrol helps your body stay young, and the secret mechanisms by which it works.
I hope you'll like it!
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Study References:
I'm working on a website to include each video with all links, with each page per video.
In the meantime, I ALWAYS show the exact study titles & years and read them aloud. Go to GoogleScholar.com, put the first 4 words only, and the study will come out as the top search, guaranteed. Please double-check me!
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✅ The favourite videos on this channel - playlist:
• Longevity Favorites
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The Wellness Messiah podcast is available on Spotify, Apple Podcasts, and Overcast.
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Credits: 'Adrift Among Infinite Stars' by Scott Buckley - www.scottbuckley.com.au
Disclaimer & Disclosure: The information in this video and/or at this channel is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge, educational and information from the research and experience of Rimon, who encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional.
Rimon is not a medical doctor. If there is a contradiction between the advice here to your doctor or local authorities, always go with the doctor and the authorities.
Statements made, or solutions suggested in this video and/or at this channel are not intended to diagnose, treat, cure, or prevent any disease.

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24 фев 2023

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Комментарии : 337

@WellnessMessiah Год назад

✅ Check the special deal of habits creation app + my routine for longevity: wellnessmessiah.com/app Disclaimer: I'm an affiliate of the company - I trust their product. Buying will support my channel

@mikelangele Год назад

Thank you so much for your video. Can't wait till the next one. Hope your wife is ok. Still watching 2 and 3 minutes ads to help you as much as possible. (letting it run on mute)

@WellnessMessiah Год назад

@@mikelangele Thank you, it really helps. Truly!

@samirahusain855 Год назад

@mikelangele

@Jacob-uv1kh Год назад

Please keep making content. You're one of the very few people who can put out a 40 minute video that I can watch every minute of. Thank you

@WellnessMessiah Год назад

Wow what a compliment!

@semaaral2498 Год назад

Same here.Trust is main key here.. God Bless Rimon & His lovely wife🙏💙🙏💙

@llacerda1982 Год назад

Following up on my last comment: Besides dose (low or high), it seems that the bioavailability of free resveratrol between rodents and humans needs to be taken into consideration to achieve the same benefits that have been found in the different studies. 38% bioavailability of Resveratrol in rodents, and < 1% in humans is a significant difference that, from my understanding, shouldn't be neglected, therefore needing a higher dose in humans to achieve a similar outcome to the ones referred in the studies.

@harborgirl8877 Год назад

I am convinced that centenarians do have a genetic component. My family, especially on my paternal side, has consistently long life spans. My father (born in 1917) lived to be almost 100, but so did my grandfather, and great grandfather. We have gone back to the 1700’s, and were shocked to see how long people in our family line lived. This was during a time when life expectancy was far less. I am hoping good genes, and following a good anti aging lifestyle will get me to 110-120. As I said, both my parent died shortly before 100, and both were active and sharp minded.

@dcjohnson2208 Год назад

Did they eat a lot of sugar or processed foods or fast food? My guess, due to their ages, they did not. Which begs the question: Do you eat lots of sugar, processed foods or fast food? If you do you may drive up the percentage of senescent cells faster than they did, thus, diminishing your genetic advantages.

@harborgirl8877 Год назад

@@dcjohnson2208, no, they did not, and neither do I. I have never been a fast food person. I’ve also always watched ingredients in what I eat. They were born in 1917 and 1921 respectively, and both were raised on farms.

@dcjohnson2208 Год назад

@@harborgirl8877 I’m happy for you. I too grew up on a farm in Illinois. I am an old retired scientist (octogenarian). I feel very good and am told by many I look 50-60. My father in law is 103 and played tennis until he was 92yo.

@harborgirl8877 Год назад

@@dcjohnson2208, Wow! That is nice ;). My Dad grew up in Illinois. A small town at the time , called Harvard, but also spent time in Belvidere, as well as Poplar Grove.

@dcjohnson2208 Год назад

@@harborgirl8877 our farm was in Lisle next to Downers Grove.

@MrHlynskyy Год назад

Wow you just converted my 2 month supply to 2 years supply.

@brazilchem Год назад

I do low and intermittent resveratrol dosage in the form of 1 bottle of red wine at once, per week.

@MP-id2po Год назад

Interesting how red wine as an explanation for the French paradox, has triggered thousands studies in resveratrol. Great job in abstracting and gathering relevant information from all the studies to create order, logic and relevance from all the "chaos"

@christopherellis2663 Год назад

The French paradox arose from the hypothesis that cholesterol clogs the arteries. It doesn't.

@Krunch2020 Год назад

The paradox is why anyone trusts American health information. It’s rotten from the top down. Sinclair is near the top.

@TehKaiser Год назад

French paradox might be because they eat better quality foods like milk and real butter, along with cultural limits on the schedule of eating. Butter does contain valuable vitamins like K2. Americans are willing eaters of industrial influence and are willing to eat bad quality foods and blindly trust big food's science saying veggie oils and trans fats were better.

@Fearzero Год назад

@@christopherellis2663 It does along with saturated fats. The French paradox is nothing more than only including peasants living in small villages in the study who ate mostly grains and beans not the high fat meals that wealthy city dwellers were consuming. Look it up.

@RestorationWatch Год назад

I think you need to recheck your calculations at 10:23 where the low dose is stated as 4.9gms/kg which would equate to 490gms for a 100kg (220lb) individual (4.9 x 100 = 490) so a 160lb person would need to be taking 350mgs/day to be on an equivalent low dose. I take 400mgs/day. Also, Resveratrol should be taken with something that has fat in it as it is fat soluble. David takes his with his morning yoghurt, whereas I take mine with my morning glass of Bonsoy soy milk. NMN on the other hand should be taken with water on an empty stomach as it is water soluble. I take 1000mgs of NMN with a glass of water first thing in the morning.

@jurgenpretsch1770 Год назад

A human is not a 80 kg mouse. At 7:49 there ist a calculation that converts the results of mice to humans. the numbers are divided by 12. In Germany the official number is 7 which means a of of 56 or 153 mg/d.

@WellnessMessiah Год назад

Hi Steph, you forgot to divide to convert from mice into humans. by 12.3 exactly. Google mice to human conversion.

@morgenstern8945 Год назад

NMN wird besser aufgenommen, wenn Du ihn unter die Zunge für 20 Minuten zergehen lässt

@maitregab4997 Год назад

Soy is an endocrinian disruptive so its bad for your health and your hormone

@MyMy-tv7fd Год назад

rather too complicated for me I am afraid, but I am excited to see that resveratrol is still being researched

@WellnessMessiah Год назад

Hi there, just check the end of the next episode, it's all you need to know, really.

@kisha_music Год назад

When is the next episode coming?

@vickypoulimenou-tesdorpf2746 Год назад

@@kisha_music Saturday

@masterjstory7887 Год назад

Absorption is key. Our body chemistries are unique. We were taught at medical school that B3 (NMN) must be taken in conjunction with the vitamin B group for it to be metabolized, otherwise it is excreted.

@petermiller4434 Год назад

were you taught that b3 is the same as nmn?

@stevecrawfordpianodreams5167 Год назад

Thank you very much for this in depth analysis of the available data. I'm glad you are doing the episode 2 on this topic because I kept thinking why is Dr. Sinclair taking 1 gram a day when the analysis so far points to a lower dose being the most effective dose. I look forward to the upcoming episode.

@WellnessMessiah Год назад

The next episode is coming this Saturday. Great to meet you, you're very kind.

@bigguy130 Год назад

@@WellnessMessiah Wouldn't it be cool if you could get the man himself, David Sinclair to discuss with you the topic of resveratrol supplementation and what dose is best and why? 😯

@mixalis6168 Год назад

@@bigguy130 He would lie all day long @

@kiwiingrid Год назад

@@bigguy130 he takes it himself. Look for a video done by 60 minutes Australia about longevity and he says in that interview. It on RU-vid btw.

@Sunyataji Год назад

Going by the graphs and estimating the number values, it seems that EODLR is an approx. 2.3% increase and HCLR is 1.4% increase in longer lifespan. Transposing that to a human lifespan of 80 yrs, would be 1.8 yrs and 1.1 yrs gain in lifespan respectively. Granted, we would all like as long a lifespan as possible and even 1 year is desirable, but given other factors effecting lifespan is the low vs high resveratrol question that significant?

@es1653 Год назад

I absolutely love this continuing free education on ageing backwards and becoming younger. I started taking 400 mg. Resveratrol daily along with my other supplements and vitamins.

@drieman Год назад

Sorry, busy person here. Maybe you can summarize your findings, and not have your viewers struggle through the data and your interpretations. However, keep your findings coming. Thanks

@slidecatch Год назад

Great video, thanks! The only solution to the mystery that I can think of is that Sinclair believes that taking high-dose Resveratrol with NMN combined confers some synergistic benefit that low-dose Resveratrol with NMN would not.

@jochemlaurenssen9440 Год назад

Yes it is said that resveratrol acts as an accelarator for nmn. Maybe that is why Sinclair takes a higher dose. I dont know if there are any studies done to corroborate this.

@WellnessMessiah Год назад

Hi there, resveratrol activates SIRT-1, not NMN. NMN should raise NAD+ (hopefully, inside the cell, not just the blood), which can be used for fuel by sirtuins (not just sirt1). Not a very strong case with zero data to take more than 100-120mg. Remember he has been taking high dose a decade before he started NMN.

@shy-guy5544 Год назад

Fascinating well-researched video. I read that high doses of resveratrol blunts the benefits of exercise. I assume that if I exercise 4-5 times a week in the morning, engage in intermittent fasting with the main meal in the afternoon, along with a glass of wine about every other day, I will receive nearly the maximum benefits of all three. Thanks

@carloscarion1748 Год назад

Pinot noir has the highest concentration of resveratrol. It has the hardest working grape. also muscadine grapes and açaí berries, as well as organic peanut butter, or boiled green peanut( a southern delicacy), and the common knot weed

@Always-xl9db Год назад

What a great podcast, and this makes perfect sense along with your other videos on resveratrol…I’ve been microdosing and pulsing it ever since!

@WellnessMessiah Год назад

Great to see you again!

@semaaral2498 Год назад

I was confused and didn't hear from you for some time & worried. Needed an explanation about Resveratrol, especially in Google, Resveratrol says works like an estrogen hormone in the body. So I've lost my excitement & trust towards many things😟 It's scary. So need good detailed info. Thanks for this video, "every effort helps" Hope your wife's health is improving every day 🙏💙 My thoughts & prayers are with her🙏💖🙏 May God give you the strength to care for your wife🙏🙏🙏 God Bless you & your wife🙏💙🙏

@JaxObsessed Год назад

Thank you Rimon!! This is useful information. ... On a side note, I hope your wife is continuing to recover.

@WellnessMessiah Год назад

Thank you Jax, she had a backslide with another clot. I hope I could update soon.

@cityinthesky1341 Год назад

Dr. David Sinclair said that determining human dosage based on mouse dosage involves total surface area for the calculation. It is not a simple weight ratio formula.

@jimsigrist5506 Год назад

Bravo! Very thorough explanation! Thank you very much. More longterm studies necessary. Need to know more about drug to drug (molecule) interactions with NMN, Metformin, Berberine, and Ficetin, etc.

@Sublimer79 Год назад

I take knotroot as an natural source (I grind the root into a powder, its also sold in powder form now which would be a lot easier) I would assume its safer since its not just isolated resveratrol. I could be wrong. But that is my source. I only drink 1 bottle of wine a month. I'm sure it does something.

@094340 Год назад

Japanese Knotweed is my source as well. I'm taking it daily, it's included in an herbal support supplement for Lyme Disease.

@reikiandrew Год назад

Can you please tell me if NR/NMN + resveratrol and GlyNac work in similar or complementary way? is it ok to take both combos?

@bluffmaster4222 Год назад

Very engaging content ! One of the few people on social media who do their home work before opening their mouth. Keep going ! Lovin' your work brother!

@count_of_monty_crypto Год назад

I wonder why the leading researcher on longevity and aging at Harvard takes 1000mg resveratrol if his own data on mice suggest lower doses are more effective for his needs. Just seems odd he that he would disregard all his own data and in fact from what you suggest earlier potentially shorten his life with a higher dose. Very odd need to clarify his exact reasons/arguments for personal/human 1000mg daily consumption. Great video but baffles me why Sinclair would ignore his own research if this is truly the case. Need to hear his own scientific reasons for 1g

@janecho2714 27 дней назад

He said he takes 500mg a day, not 1g.

@count_of_monty_crypto 23 дня назад

@@janecho2714 no lots of interviews of him specifically stating 1g every day.

@mikec5544 Год назад

QUESTION. What about Trans-Resveratrol? My reading seems to indicate that Bioactive Trans is more effective. So if we buy into this 30-100mg low dose resveratrol, how would this translate to the Trans version in terms of dosage?

@dontaylor8912 Год назад

I really liked this presentation, Rimon. You revealed plenty of useful info. David Sinclair has repeatedly stated that resveratrol is needed to fully activate NMN. He gives the analogy of accelerator and fuel. Low dose resveratrol is helpful for lowering insulin and glucose but is 50 to 120 mg enough to effectively activate NMN?

@WellnessMessiah Год назад

Hi Don resveratrol activates SIRT-1, not NMN. NMN should raise NAD+ (hopefully, inside the cell, not just the blood), which can be used for fuel by sirtuins (not just sirt1). Not a very strong case with zero data to take more than 100-120mg. Remember he has been taking high dose a decade before he started NMN.

@murrmurr765 Год назад

@@WellnessMessiahThe question is if 50/120mg is enough to create the synergistic effect between Resveratrol and NMN he mentions. What do you think about it?

@gloriagolemboski4515 Год назад

You talk so fast. For me. So per weight how much resveratral and how much nmn. Where do I get it.

@its1me1cal Год назад

Every other day for mice so what’s the equivalent for humans? I’m sure as mice live much shorter lifespans, it wouldn’t be every other day for humans.

@bilbyguy2389 Год назад

What a great video. I am fascinated. Well done on all your hard work.😀

@mieciuuu506 Год назад

Hey, how much resveratrol to take for a person who weighs 90 kg? is Japanese Knotweed Extract or Pure Trans-Resveratrol Better?

@harborgirl8877 Год назад

Thank you for explaining this subject in a way I could understand. Your research is appreciated!

@vapeking466 11 месяцев назад

I don't get why Trans-Pterostilbene hasn't replaced resveratrol. From my research its superior in absorption and nearly identical otherwise. Maybe I missed something or it hasn't been tested yet. I been taking 200mg daily for a year or more now.

@rolandbrecher4265 Год назад

So what is considered as "low" dose resveratrol? Most of the Supplements have at least 500mg of resveratrol, is this considered as "high" dose? Should I avoid taking them?

@emilguste Год назад

Really good work mister, looking forward to the next

@WellnessMessiah Год назад

You're very kind emil. the next episode this saturday.

@jackd9820 Год назад

Rimon, I am 71 years old and one of those seniors who exercises every day ... elliptical, resistance, swimming. Since taking Revesterol before exercise is not advised am I OK with taking it after exercise on each of the 5 days with a breakfast meal?

@jackd9820 Год назад

Rimon, I assume I could do the same with metformin??

@WellnessMessiah Год назад

Hi Jack sorry for the later repones. Not medical/personaized advice - yes taking after should be fine - with meal. Meformin, it's in the system for 17 hours. It won't prevent exercise benefits, just muscle "growth". If you maintain muscle mass, like me, than you shouldn't be worried about it. Make more sense to take metformin i the evening, as exercise will burn sugar anyhow, and so metformin ill have 16 hours before exercise to do its magic

@NTMihaila Год назад

I love your channel man! Keep the excellent content coming!

@WellnessMessiah Год назад

With comments like yours, what choice do I have?

@aljosarojac8575 Год назад

Great investigative work. Well done 👍

@drunvert Год назад

Remember, mice have a 6x metabolism. So every other day is EVERY 12 DAYS for humans. That's almost a two-week fast

@lventer165 Год назад

What about SALVESTEROL? Please tell me your thoughts on this

@mysimon2003 Год назад

Can someone post a summary here 🙏

@CommanderRiker0 Год назад

Best presentation yet

@raibalama Год назад

I think the basic problem is sugar which is new for humans so get rid of sugar and all carbs in your diet and you do not need any compounds that reduce sugar in your body. I advise my patients who are obese to avoid 4 items: bread, rice, basta, and all sweets.

@alexk48 Год назад

What about starchy veg? If one replaced bread with a potato at mealtime this would simply be a carb replacement.

@eyeswideopen7777 Год назад

If they are blood type O .. yea. They get fat easily if they don't get physically active. Asians with B blood type don't put on weight

@alexk48 Год назад

@@eyeswideopen7777 Asians put on visceral fat. They don't put on a lot of subcutaneous fat so they don't appear fat. India + China have the highest rate of Type 2 Diabetes and associated diseases in the world. They have for a very long time, well before the diabetes epidemic in the west. Check out old WHO reports. Also look at the more recent pictures of abdominal CT scans on seemingly normal weight Indians.

@eyeswideopen7777 Год назад

@@alexk48 India and China have adopted alot of western food style cuisines into their diet. Pizza, coke etc

@Skiskiski Год назад

Thank you. I stopped taking resveratrol.

@CamiloVergaVideos Год назад

Thank you very much for the video and analysis! It is very interesting! But I think there is something very important that is not being mentioned. When doing the test tube studies with cells, sugar and resveratrol there are no problems with bioavailability. The question, in the case of humans, is how long a capsule or powder reaches the cells after passing through the intestines. Maby a dose close to a gram is necessary for some of it to reach the cells. Thank you very much and greetings from Buenos Aires.

@WellnessMessiah Год назад

Very interesting Camilo, great to meet you here.

@CamiloVergaVideos Год назад

@@WellnessMessiah Thank you very much Rimon. I'm stay tuned to all the videos you upload. A hug!!!

@andreasmarx4427 Год назад

Yes, will depend on the condition and capacity of the small intestine to assimilate the RSV.

@pepeponcela Год назад

Rimon, here's the problem: videos 45mn long are a non starter, particularly when you start talking about some study in rats from Sinclair... more than 15 years ago. Take a leaf from Brad Stanfield: if you can't condense someone else's research in less than 10mn, might as well read the paper. Sinclair: it still amazes me how much credit this guy has. He made a fortune on a resveratrol research that was not replicable in 2006... and ignores all thr research since then. Great stuff.

@WellnessMessiah Год назад

Well my style is different. It's awesome for the viewer: if a person has the mood for a 4-minute video, he has brad. and when you're in the mood for 40 in-depth education you have me. What I can tell you is that this in-depth style achieves real results in humans = my clients. I witnessed it. The devil is in the details. Even if they take 40 minutes :)

@pepeponcela Год назад

Fair enough! I guess what I was trying to say is: I like what you do (that's why I'm here!) but don't have the time for 40mn videos! Probably the sweet spot for people wth busy schedules is somewhere in between (eg 20mn). And less focus on what Sinclair does, he made a tremendous contribution to the field but he's not at the forefront and no longer well respected in the scientific community. There's great research coming out continuously in the longevity field!

@alexk48 Год назад

Saying what people want to hear is very lucrative + will get one a lot of attention.

@pastamandjinka Год назад

@@pepeponcela How come he is not respected no longer...?! Pls specify .

@Steger13 Год назад

Can we buy resveratrol over the counter pr need doctor prescribes ?

@tutubedo Год назад

Available on line. My Walmart carries it as well (over the counter and about $1 a day).

@bilbyguy2389 Год назад

A quick question; Is the low dose a daily dose or every second day? I think I heard Dr Stanfield saying he does not take it on the days he exercises. Do you have any info' in this regard. Thank you so much. This ride in like a Tom Cruise movie! But your video has more longevity 😄

@WellnessMessiah Год назад

Yes, this is episode 3. Deep dive as usual!

@dantwister5106 Год назад

I only care about resveratrol and quercetin because they increase the effects of caffeine. The idea is taking low dose caffeine every other day to prevent tolerance. What does caffeine do? It makes running and working out easier. Why working out? To be healthier and to live longer. Probably I will also need piperline (black pepper) to increase the bioavailability of resveratrol.

@Thaythichgiachanh262 7 месяцев назад

Thanks for all your great advice. I really enjoy watching your videos, they provide a lot of knowledge and are very helpful on a daily basis in choosing food when shopping, etc. Thank you ❤✨

@wpmitra7251 6 месяцев назад

You sound like a native English speaker when I watch the video at 2X speed XD. Not kidding. Please try that once. On a serious note, I got the answer to something I've been wondering about for some time. Which is whether non alcoholic red wine gives the same benefits as the alcoholic one. Thank you for clearing that up. Knowing this is very important to me because I don't want to drink alcoholic beverages.

@MrCt40 Год назад

Thank you for doing the hard work on clarifying this confusing area - which brands of resveratrol do you like to take ?

@reinerheiner1148 Год назад

I highly doubt that we can simply convert dosage from animals to humans, because absorption of resveratrol is very different between humans and animals. Thats why we see a lot of positive data from animal studies but the picture is a lot worse for human studies. So unless you account for the difference in bioavailability between humans and animals the conversion is plain and simple wrong.

@levondarratt787 Год назад

It's even different from Human to human.

@jstntowner11089 Год назад

What is your opinion on Resveratrol vs Trans-Resveratrol? Is one gonna make a difference over the other or is that just supplement manufacturers trying to market their products to sell more?

@dmpag7000 Год назад

excellent and very thought provoking

@raibalama Год назад

sorry to say that D. S. turned from a sincere scientific adviser to a commercial pharma when he figures out that what he is doing has a financial reward. what a pity!

@dude861 Год назад

I wouldn't consider red wine as "low dose Resveratrol". Considering the studies on mices etc as well as your interpretation you would consider the optimal dose roughly around 100 mg Resveratrol a day for fat/unhealthy people or every 2nd day for healthy, normal people. Red wine has roughly around 1mg per glass. So putting them into the same group does not make sense to me since it has FAR LESS Resveratrol than all the other studies (were i think the lowest doeses were around 33mg).

@sawza0313 Год назад

Thanks a lot ❤❤❤❤❤❤🫶🏼🫶🏼🫶🏼🫶🏼🫶🏼🫶🏼 I have taken 500 mg almost everyday with the weekend off, and I have taken resveratrol totally wrong! I’m intermitted fasting at least 16 hours and took resveratrol in the morning and about an hour before NMN It has been huge changes with my energy in a positive way but I have gained weight , about 5 kg since last year 😢

@JenP2776 Год назад

Cannonau grapes/wine from Sardinia has the highest level of resveratrol!

@tahsin95 11 месяцев назад

This is a great study, thank you so much. Subscribed.

@theluckyman74 Год назад

The only problem, is that, Regular Exercise, can also, increase longevity, but are they, synergistic or, the opposite

@paj6757 Год назад

Very well explained and practical.

@ash9x9 Год назад

So, What is the crux? Haven't had the time to go thru the entire stuff..!

@MP-id2po Год назад

@@ash9x9 Get a life.

@emil8367 Год назад

It is simple. He (D.S.) is not wrong. He knows exactly how much is needed to prolong longevity, but selling much more is more important to him, to spread information.

@keng7758 Год назад

I don’t believe Sinclair has any ongoing involvement in any company that produces Resveratrol. Stick with facts please

@emil8367 Год назад

@@keng7758 this is only about his knowledge about it ;-) you don't believe, I believe in this case that he knew (he is a scientist, and he knows his job, the field which he works on for so many years, and also he knows how business works, how easy is to convince desperate people especially or people who want to live longer - read forever, who won't say this at loud of course and will deny). But I still like the idea of longevity and living for very, very long healthy :-). But, in general D.S. is OK, but I don't like these games related to business and when they don't say all information !

@NeuroNate24 Год назад

so just to confirm we’re supposed to take resveratrol every other day? And we have to go based off of the calculation provided to us for our body weight?

@0906mlynek0906 Год назад

Hi, I don't know English, tell me is it better to take a little Resveratrol or a lot? weighing 90 kg? And is it better every day or every other day?

@NTMihaila Год назад

Didn't you already make a video talking about how low-dose cycled resveratrol is ideal? Around 100 mg daily, a few days on, a few days off. I recall you talking about how low-dose resveratrol restores senescent cells.

@WellnessMessiah Год назад

Yes Nicholas, go to the community tab on my channel to see how inquired about integrating past videos into 4 episodes. the first 2 are based on published information, and the 2 after are completely new.

@NTMihaila Год назад

@@WellnessMessiah I, gotcha. And thank you for the response. :)

@thelasthallow Год назад

the only thing that sucks is that there are tons of companies out there making these products and its hard to say which one is the best, for Resveratrol, all i know is it should be white and crystilline, thats the only way you know its good supposeldy. my first product i bought from walmart (yeah i know dumb) was a freaking liquid, so now ive pulled out the shotgun and spent over $60 on 3 different brands to see which one meets those 2 criteria. ive tried looking online for reviews but this is all new to me so im not sure what websites to trust or what brands are the best since most people that take these suppliments dont actually know that much about what they are taking.

@katewright632 10 месяцев назад

Pterostilbene is a more bioavailable stilbene that is fat soluble and has a longer half life in the body. It is highest in blueberries but potent in supplements. Resveratrol needs a certain amount of black pepper with it to increase its half life. I'm not sure if it can change from water soluble to fat soluble.

@llacerda1982 Год назад

Great content, thanks for putting it together! What's your view on the bioavailability of resveratrol in mice vs humans? Could humans need a higher dose to factor in a possible lower bioavailability of resveratrol in humans, but still achieve similar results to the ones achieved with the mice on every other day feeding with low resveratrol?

@lynamine Год назад

Excellent podcast!

@josephshawa Год назад

So what exactly are aging genes? How is it resveratrol stopping their expression specifically? Did I just miss it?

@jgs9911 Год назад

Another excellent video. Thank you. BTW: your English is perfect

@jamiesouza Год назад

Why would David Sinclair take 1 gram of resveratrol and go against your interpretation of his own studies?

@VXingxu 7 месяцев назад

Hello Rimon. What do you think about cycling resveratrol at comparatively lower doses to help with longevity and insulin levels i.e. 300 mg? You did mention cycling was used in the mouse studies. Furthermore, I am wondering if the bioavailability of resveratrol is different for mice as compared to humans?

@TheMarczan Год назад

Great job! Thank you so much for this video! :)

@jeannineosorio6566 Год назад

Good evenig Rimon! I have recently added NMN and TMG. I currently weigh 125 lbs. How much resveratrol could I begin taking? Thank you and I look firward to your next video.

@constantinepatsalos2243 Год назад

I love your channel ❤ But why we waisting time try to prove Dr Sinclair wrong?

@WellnessMessiah Год назад

It's more about taking the viewer through a research journey that can make a huge difference to their longevity over a lifelong habit. The viewer longevity here is in the center, not Sinclair, despite the marketing of this video.

@havad3938 Год назад

Excellent analysis! Did they compare the mice, or people to those that did not take any reseveratrol? Perhaps im missing something. thanks

@33Crazydude Год назад

Wow, what a great video 💗

@WellnessMessiah Год назад

You're very kind, thank you!

@33Crazydude Год назад

@@WellnessMessiah ❤

@aryahd8260 7 месяцев назад

Then why are all supplements so high? Marketing, because people think higher is better?

@tomg5405 Год назад

you take conclusions too fast, you can not compare reservatrol and red wine as in red win are more polyphenols not just resveratrol, so you can't know which one works.

@say6837 Год назад

Is fasting and taking low dose resveratrol on the same day more effective than just fasting?

@longevitylover6273 Год назад

The new video, i think episode 3, speaks about fasting and how resveratrol isn't necessary when we fast

@Michael_RareZebra Год назад

Thanks for the in-depth review

@V_Dgt 11 месяцев назад

Great reseach and video! Thnx So, now, the question is, what Sinclair's thoughts on low dose according to these data?

@pjaworek6793 Год назад

Thank you, so much detailed information. I'm eyeballing for about 50mg every other day from a 600mg (50%) pill.

@WellnessMessiah Год назад

That's exactly what I do today, good catch!

@EmilioS.-bs7ld 8 месяцев назад

I have downloaded the 10 Resveratrol Habits, which give very practical tips for cycling and Hit&Run supplementation. So far I have been using micronised resveratrol for its higher bioavailability, which I believe is what Sinclair used in his published research from which you derived the intermittent cycling human dose of about 100mg every other day. However, the suppliers mentioned in your habits have plant-based, non-micronised resveratrol. Does your recommended dosage apply to both forms of resveratrol, or should it be adjusted for the micronised form, and if so, what would you recommend?

@Marshadow69 Год назад

Presumably the benefits of resveratrol in de-alcoholised red wine would be the same as red wine?

@dontaylor8912 Год назад

I had the same question about Welch's Grape juice. Certainly plenty of polyphenols.

@WellnessMessiah Год назад

I think so Paul. but alcohol makes it more soluble in humans, maybe over fruit flies. So it could be a benefit right there.

@SeattleCondoSpecialistcom Год назад

Bravo. Great Information!

@NotArtic Год назад

Is eyes safe

@donkeyhota.dontflamingo9294 Год назад

Hay Rimon, if a guy doesn't follow your longevity advices for the first 60 years of his life and start applying them when turns 60, and another guy was applying your advices on longevity for the first 60 years of his life and stopped doing it once he turned 60, who of both do you think has more chances to live longer?

@WellnessMessiah Год назад

mmm it depends. my experience with my clients is you can actually reverse some aging damage even in old age. That's how this 65-year-old woman reverses 22% of her bone loss, and I have seen in with other people in different aspects of health. check it here: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-S0zvpeWvU_k.html

@joannsmith9 Год назад

Bravo! Brilliant!!

@semaaral2498 Год назад

Thanks, a lot for this informative podcast. Yes like you've heard me. I've read these results and was worrying a lot. So hard to find a spoon with 80_100 gr to calculate but find a way to calculate. The original spoon is 250 mg which comes with the powder from # donotage I think of your wife & sending my prayers. Looking forward to seeing you together again. She is young so with your super care will heal one day, hopefully.🙏🌹 Thanks for this video. Very useful🙏💙💯🙌

@semaaral2498 Год назад

🙏🙏🙏😔

@gz625 Год назад

It's too late for ya😂

@semaaral2498 Год назад

💅🙏💙🙏💙

@supercal333 Год назад

Just eyeball it. Precision is not required. The optimal dose is different for everyone anyway based on how well we absorb it. Don't get too hung up on it.

@willowraine5514 Год назад

…or get a milligram scale…

@karinak3487 Год назад

Thank you sooo much for such a valuable info!!! ❤ blessings to you ❤

@michelekurlan2580 9 месяцев назад

More interested in Ramon's protocol. How to get this?

@mieciuuu506 Год назад

The Visanto Resveratrol Liposomal brand has the best quality in the world supposedly

@fwdolphin Год назад

You are very thorough and so much so it made my head spin. I just wanna know how much to take for someone that weighs about 200 pounds.

@daneel_olivaw Год назад

But the high resveratrol group had mice that lived to be more than 155 weeks old, in the low resveratrol group no mice survived 145 weeks

@edouarddebonneuil149 Год назад

Isn't resveratrol is quasi not absorbed by the body? In the specific study, isn't it the control that is short lived? If large doses of resveratrol lead to a lower lifespan, isn't it because some is absorved? My questions might be naive, but I prefer to make sure we get things right

@507thug Год назад

Insightful!!! Thank you

@unboximage1292 Год назад

your best video, I think. LOL

@KenjohaMedia Год назад

I say an interview with David I think it was one of the Lifespan videos or Huberman Podcast he said the calculation of mice weight and human is not 1 to 1 based on our weight differences it was actually lower. I don't remember the percentage he said to use I am not totally sure but I think it was 4 to 1