I was diagnosed with RA at Mayo Clinic my anti-CCP test was so high it was off the chart. My CRP test was at 22. MRI showed erosions of joints in my wrists hands and elbows. 7 years later now and I have never been in remission after dmards and biologics. I was told if your positive for anti-CCP that the RA May be more aggressive and resistant to drug treatments. Is that true?