May i ask you in which quantity you Mix methylene blue in and how you apply it? I have methylene blue in liquid Form and a bit afraid to stain my face blue
I was bold to try methylene blue for hair toner that worked great to take brassy like orange out of Hair then got bolder to add from drops to squirts from dropper in shampoo/conditioner to make beautiful blue highlights that gets compliments all the time. I add one drop with night time care products and notice improvement of thickness and hydration and also balance of tone in my face!
Clare, you asked an excellent question about penetration of methylene blue into the dermis and I would be interested in hearing a more complete answer. I took a look at the Nature paper. They did not do a penetration test. Without data indicating that methylene blue reaches fibroblasts in the dermis, it is unreasonable to expect direct effects on fibroblast senescence, regeneration or direct inducement of collagen and elastin production by fibroblasts. As a result, much of the paper's data showing improvement in skin structure are only theoretical. If the compound can't get to the cells, it's not really fair to expect it to work. I look forward to hearing a more complete answer from Dr. Cao about skin penetration.
Funny enough I was actually doing some research on this topic yesterday completely unrelated to this video. From what research I've conducted, you could use 1% hyaluronic acid powder or granular soy lecithin to aid in delivery. Alongside that, MB is 284.4 Dalton of which, as a rule, 500 is the threshold for what can be absorbed by the skin. While this isn't DEFINITIVE confirmation, I think it's safe to say that penetration isn't an issue. I would also like to see more thorough testing in this regard.
@@denofpigs2575 Thank you for addressing my question. I was so bothered by the interviewee' mumbo jumbo response to Claire's question, that I didn't actually go and look to see whether there was any literature. I looked at 2 studies. There are others as well but the first two were consistent so I didn't bother to look at all of them. So this is not definitive, but suggestive. The first study found no diffusion of methylene blue into the epidermis after 3 hours. (Methylene Blue diffusion in skin tissue July 2004Proceedings of SPIE - The International Society for Optical Engineering 5(30) DOI:10.1117/12.572047). This was a diffusion study, not a penetration study. They bathed the skin sample in methylene blue and measured how much was absorbed by the skin over time. There was no absorption at 3 hours. The second study was a formal penetration study (PMID: 37242613). They looked at the penetration into the skin after 16 hours of exposure. No Methylene blue penetrated through the skin. After 16 hours, about 10 percent of the MBE was found in the viable epidermis. They didn't measure penetration into the dermis because that was not their target. So it is highly questionable that sufficient levels of MBE make it through the epidermis into the dermis. And even if MBE made it into the dermis, the first study indicates that the interaction of MBE with glycoaminoglycans like hyaluronic acid would prevent its diffusion throughout the dermis. So yes, my question stands.
Just because we are told to use retinol does not make it right. Think about what we‘be been told- low fat, low sugar - now we know the truth. Oh, and we were told in the 50s that smoking was good. I’ll believe Dr. Cao.
I believe science and there is an abundance of robust studies on Tret. Can you cite the study from the 50's that said smoking was good? Do you mean "we were told' to mean the advertising, because we all know we can't trust that. We do acknowledge that RU-vid is one of the latest and maybe very successful forms of advertising.
@@cindysmallwood2695y mother’s doctor recommended she start smoking in the 1950’s to help calm her ‘nerves’. Just research some of the smoking advertisements from that era. Saw one from a company that said doctors endorsed their brand. I don’t remember which brand but it was a major company. Every ad that portrayed sexual innuendos had people smoking along with every movie constantly showing people smoking. Inside. Whether there were actual studies or not means very little. It was a cultural attitude. As far as studies my understanding is initially studies were squashed by the tobacco companies so what you’re looking for may not exist and may not have been done as smoking wasn’t suspected as a link. As the poster stated we were told and it was generally accepted that smoking had benefits, she didn’t say there were scientific studies. Once those started coming out in the sixties the acceptance of smoking changed.
Interesting. I got a urinary tract infection 2 years ago and the pharmacist gave me a medication that contained 4 active ingredients, the main one was an antibiotic and one of the supporting ingredients was methylene blue. She warned me that it would make my pee blue, which it did, but it worked. I had never heard of this ingredient before.
@@sandyjones1014 Not really...typical dose is 0.5 to 1mg per kilo body weight and one drop of 0.1% mb is about 0.5mg, so unless you weigh around 20 kilos, 20 drops is a good dose.
So do I. They do not deserve such a crummy FATE. Children born with this disease, need a FIX. It sounds like this scientist can help them. No matter how much love and care they experience...their lives are a struggle...and way too short.
This is a fantastic interview. Oxybenzone actually disrupts hormones! They say 'it may' interfere with metabolism, thryoid function, and many other processes that are regulated by hormones. It has been detected not only in urine, but also in breastmilk, blood, and amniotic fluid! I for one refuse to take any chances with - "it may cause". 'It may' to me means it does, they just don't want to hurt the bottom line. How many products have this ingredient? Especially when there are several other, including purely organic options available - we should not put our health in jeapordy. Thank you for this!
Hi Clare, I investigated this product range some time ago. Unfortunately their range contains several fragranced essential oils and vitamin C which I am unable to use due to my sensitive skin. I understand the addition of vitamin C as a popular antioxidant but the fragranced oils are superfluous. I wonder why add the vitamin C if methylene blue is itself an antioxidant? Bluelene, please consider reformulating without the essential oils 🥹
Thanks for sharing your feedback - I'll pass it on to Bluelene. I know they carried out some research and found combining vitamin C with methylene blue increases its effectiveness but I think it's only added to some of their products. You're not alone in mentioning you find the essential oils irritating.
I'm the same. Essential oils burn my skin, causing it to flake and peel. I'm sensitive to vitamin C also (and other things). I was disappointed to see that I can't use any products in the MB line currently.
@@thehonestchannel Thanks for taking the time to reply & explain the reason behind the additional vitamin C. Love your content & the intelligent discussion 🙌🏻
Thanks for another interesting and informative video Clare! I don't know if it's just a matter of makeup and lighting, but your skin is looking particularly lovely in this video! ✨️
Thank you for this video. Very informative. I love the information you provide…. You always look nice Claire, but your skin is glowing and looks better each time I watch. Very beautiful 💕
My only objection to the product being sold is that it contains PEG 100. PEGS are always on the dirty list of ingredients in all beauty products. Wonder if they could readjust their formula?
Ive been taking 5drops food grade for 3 weeks, i cant believe the difference in my depression and anxiety, wouldnt want to add it to my moisturizer because of the blue dye x
Very interesting video! Shouldn't we use retinoids some months just to renew our skin cells and then take a break ? And then use something protective, that make our cells live longer, instead of pushing them to renew whereas they are perfectly fine? I'm testing Age Proteom from Esthederm, have you heard about this new approach of anti-aging? 😊
@@thehonestchannel yeah the science behind this product is fascinating! It helps to protect our proteins that protect our DNA. I'm using it since less than a month so it's a little soon to see results but I can say my skin is very calm 😌
Hi Clare, just wanted to update you that I bought the night cream on sale. It's a beautiful cream but the fragrance is so strong I can't stand it. I almost washed it off my face. I really smells like strong citronella... I may just use it some my eyes in the morning. I tried the top of my hands too but it's just so strong smelly....I must say that I woke up with very soft skin and my eyes definitely looked better in just one night. I wish they time down the smell. I have other Korean products that are just beautiful and with such delight fragrances that I will continue to use. I definitely will not reorder for this reason unless they minimize the string citrus smell it has. Maybe you can provide this feedback to the company too. Love your channel!!!😊
I'm so sorry you didn't like the product - it's always disappointing when you're excited to try something new and it doesn't work out how you expected. I don't mind the smell but I know we're all different! Thanks for following the channel!!
@@thehonestchannel by the way I reached out to the company and they are working on having it either without scent or minimal scent which is great. I definitely think this cream is beautiful and healing so once they offer the ones without scent I will try it again. 🙂
Thanks Claire! You might want to look into Nano Soma. It's an Amazing oral supplement, & they also have a topical skin cream as well. The plethora of research on Nano Soma is pretty Incredible for what it can do for us health wise, so I can only imagine what it can do topically on the skin.
Very interesting, pertically the antioxidant aspect for happy cells..because ive actually have been taking glucosamine for overall anti aging benefits with good results, so i decided to research glutathione cream..although it's not marketed as an anti aging, but a skin lightening..i thought l'll test it anyway, I'm thrilled that i did bc i am seeing a difference in my skin! I have ordered the Bluelene as well and anxious to give it a go..thank you Claire😊 your channel is so valued with me..keep up the good work..we appreciate it immensely ❤
After being happy with the effects of using methylene blue orally I bought a bottle of methylblue and notice no effect from it. Also it seemed to have no noticeable bluing effect which made me wonder the amount of methylene blue in the skin cream. Suspect it must be extremely small.
Thank you Claire methylene blue is interesting and i have been thinking of trying it since Claudia spoke about it. I see the serum does contain essential oils which i try to avoid as i have sensitive skin. Have you heard of a skin product called plated. It uses stem cells from human platelets rather than from fat or placenta,like calecim. I have used calecim for about 18 months and i like it but i was alarmed to find out that using the same original tissue sample and multiplying it over and over in the lab can cause mutations in its dna. I would love some clarification on this as this claim was made by the dermatologists involved with the platelet skincare line.
@@shar7508 Hi, yes, i heard back from them when I was on holiday so excuse the delay. Here is the response from Calecim for you now: This is a good question - it is true that we use the same tissue sample for all of our active ingredients. ( The umbilical cord lining, not the placenta ) . The reason we can do this, and we are the only company that can, is because of the age of the stem cells. They are incredibly young. They are also infant stem cells, so they do not lose their "stemness". We have pushed out stem cells up to passage 30 ( 30 replications - so 12 Billion to the power of (30x29x28x27...) so on so forth and the stem cells did not lose any potency. There was also no mutation or change to the stem cells. We are not using the Stem cell itself, only the proteins that are secreted by the stem cell. Platelets are good, but the proteins you are adding back onto your skin are going to the age and the health of the donor. i.e. if the doner is 35 and overweight ( poor health ) the proteins will not be as powerful and effective as younger proteins. Stemness combines the ability of a cell to perpetuate its lineage, to give rise to differentiated cells, and to interact with its environment to maintain a balance between quiescence, proliferation, and regeneration.
The SPF is only 21 but I understand this does not include the methylene blue part of the sunscreen (not yet FDA approved). That being said, when she did the study comparing sunscreens, what % of oxybenzone sunscreen was used to measure against methylene blue? I have used the Bluelene sunscreen and because it is a low SPF and it leaves a blue/white cast, I have added another (tinted) sunscreen over top of it. But I would feel safer not to use so much sunscreen on top if I knew Bluelene was comparable to say an SPF 40 or 50. One other question- the methylene blue is super low on the ingredient list. I was taught that an ingredient that far down on an ingredient list would be minimal or no effect. Is that enough of methylene blue to really make a difference?
Hi. I've had the following response from Dr Cao to your questions: "In the experiments, we used the same percentage of oxybenzone to compare with the same percentage of methylene blue (at 100uM and 1 mM). "As for sunFix, I use it without any lotions in the morning since it is formulated similarly to our daily moisturizer. You are welcome to add your other routine to this protective layer. We also believe, unfortunately, the SPF testing (done by a standard lab) was not as accurate as we hoped so (The Bluelene SUnfix is at least SPF 30 in our in house testing). In short, I don't think it is necessary to add another SPF on top." On the question of is there enough methylene blue to really make a difference? Dr Cao says, "Yes, Methylene blue is used at the optimal concentration (as indicated by our in vitro testing). It is a low amount, so it wont stain your skin blue : )"
Methylene blue stains like crazy at it's full concentration. It's used in the aquarium trade to help cure fish that have fungal disease and clear a protozoan that causes ich. You have to be very careful not to spill it, any silicone or soft plastics in the tank will stain blue during treatment. This staining of the skin is why it's so low on the ingredient list. If you used it full strength you'd look like you were auditioning for Avatar. 😂
Hi I read the paper and the concentration that was used was 0.5micromolar to 2.5micromolar in the cultures. I did some math to come up with adding 2micromolar in an approximate 1:5 volume of vitC serum, I use timeless which is L-ascorbic acid, it cuts the blue (a lot of people do this before drinking. I figure this is in the range they used even if the dilution is not precise. I apply this to my skin then follow with a tinted physical sunscreen. Heres the math: I figured out the moles using an online miles to mg converter. It ended up being 0.5micromole=0.016mg, I then diluted the standard 1% solution which is 10mg/ml by mixing 1ml to 25ml water which makes it 0.4mg, if you use 1 part of this in 5 parts mixer (vitC in my case) the it’s in the range of the skin experiments. MB is super stable so I imagine it can be mixed with most substances? I was wondering if the Dr. could tell us the actual concentration in their products?
Wondering if you could add an update around your current experience with bluelene and if you are still using it. I also wondered how to layer serums with this product. Thanks
Hi. I still use the Bluelene sunscreen daily and love it. I talk about it in my recent video running through my skincare routine. You might want to drop Bluelene an email directly with questions around specific products and where in the routine to use them as they would be best placed to advise.
I don't see a link to the Bluelene product line. You should add it to this video. At least as a courtesy to the founder of the line, whom you interviewed here. Would have been even better if you could have offered a discount code when purchasing her products. Missed opportunity
Is it OK to put one or two molecular hydrogen tablets in 16 oz water along with methylene blue at a rate of 40 drops of 1% for my weight of 140 lbs? I also use DMSO over top of Povidone Iodine (Betadine) several times a week, which heals almost by the next day, any cuts or scratches or bruises from construction work or the cats . I also use liquid chlorophyll daily, as well as a whole ground up lemon minus the seeds. Does methylene blue compete with NO? And if you take beet root powder and other NO protagonists such as arginine, will that nullify or reduce the effects of the methylene blue? I also take colloidal silver on a fairly regular basis. What kind of reaction do these chemicals have on each other. I am now off of all my prescribed (15 to 17) meds, when my Doctor fired me for trying to reduce my pharmaceutical load that they had me on a few years ago. My health has since improved about 1000% since I was fired by my Doctor and they refused to "treat" me by my "Health Professionals". I had diabetes, high blood pressure, GERD, 3 degenerated disks, ADHD, OCD, major depression, anxiety, arthritis, probably NAFLD though not obese (then about 165 - 170 lbs. and then height of 5’ 6” down from 5’11” in early adulthood, but have since have regained a little over 1 inch back again, and now about 140 lbs and lost about 7 inches in my belly, after about 3 years on keto), and more. I am now 71. If you or anyone else can provide me with good information on the interaction of these chemicals, it would be greatly appreciated. Thank you very much for your kind response to this request. Spencer Douglas James djames314 (is at) (g)mail (at dot) com spence3141 (RU-vid)
I talk a little about using Bluelene in this recent video about my skincare routine. I use the sun cream for daily sun protection and as a moisturizer. I love it but it has a slight fragrance and also contains some essential oils.
Actually I am. The min. effective dose or therapeutic dosages matter. Once you take into account absorption, assimiliation into metabolic pathways etc., many consumer focussed solutions are not efficacious. @@Adhara740
Just ordered the pharmaceutical grade 1% Meth Blue.. nervous to try it ( I don’t take any meds at all ) But I heard it might be worth trying internally ( carefully) .. good to know i can possibly add it to skincare 😊
Clare are you still using Future renew by no.7? I have the night cream but have not gotten the serum yet and if you are, how are you incorporating it ?Plus what skincare are you using from MB? I will def be purchasing some.
I gave the No7 serum to my mum to use so I could try out the MB. She loves it. I’m using Calecim at the moment but I intend to switch between that and No7 as my peptide go-tos for now. I use Bluelene morning and night. So I use the daytime moisturizer after applying my vit c serum, and then I use a little night cream before applying Calecim. I mainly use it at night in the hope of boosting the effects of my red light mask! If I was using the No7 serum I’d apply the MB night cream as my moisturizer after applying the serum. Hope that makes sense!
Hi Clare, how do you still like the sunscreen. Does it have a cast and how much protection have you noticed. I live in Florida, USA which is extremely hot and very high UVA rays, etc. Always looking to try new sunscreens. I am using the kitten Korean Madagascar one which I love. And the Coty one which is very thick and has light tint. I have dry skin so I don't mind it. Thank you!
Hi. I still use the sunscreen every day and I don’t find it leaves a cast on my skin though I did have a viewer recently complain it did. I live in Scotland where we have a lot of cloud cover but I found it held up well when we went to NY recently for a week where the sun was more intense.
Why all the Bluelene product are no longer sold on the site? I'm waiting for my package but it's 15 days that it has been stopped at the post office... I'm a bit worried.
Hmm. Just took a look at their website and can see the products listed okay. I recently ordered another Sunfix moisturizer without any problems. Have you contacted Bluelene direct? support@magicbluelabs.com
@@thehonestchannelI can only see their new neck and face cream and the other products are disappeared. Maybe they won't sell them in EU or, in my case, Italy anymore.
I use a retinal every other day and use Bluelene daily so there's no hard and fast rule. They work very differently so while methylene blue enthusiasts might say you have to pick one over the other, combining them is actually working quite well for my skin!
I have used this product and can’t honestly say that I’ve seen a difference in my skin. I also asked for before and after photos but never received any. The product also has an off putting fragrance.
That's interesting to hear. I like the fragrance but I do think skincare is a process of trial and error to find out what works for your own particular skin type and preferences.
IMO, your facial skin appears tighter since you've been using the MBlue. Re: retinoids, I think like most things, one size does not fit all. However, looking at women who have used them for many years with much success, it appears they do not cause damage in the long run. Actually, the retinoids seem to do the opposite. For myself, my skin improved when I started using retinol and then retinal. That said, I don't wish to use tretinoin.
Thank you. I think there are a few contributing factors to my improved skin health and volume of late, but I'd say MB is one of them. Totally agree re retinoids - and other skincare actives. I still use a retinoid every other day and would be loath to drop it from my routine at this point in time. When Dr Cao said the future of skincare was a personalized approach I thought that was spot on. Different skin types could benefit from different approaches but we're just not quite there in terms of working that out yet!
@@amperage8032 Try searching for Adipeau face cream for targeted fat restoration. There are some interesting videos following up on the regimen here in this amazing channel. Hope this helps! 😊❤
I'm using Geek & Gorgeous retinal every other day at the moment. No skin sensitivity issues. I think the main points with methylene blue in skincare are that it's been found to prolong the life of skin cells, prevent oxidative stress and even act as a UV filter, though not one that's presently approved as a UV filter.
I really like it. I actually use it morning and night at the moment because I'm so taken with it - so I apply a vit c serum before using the Daily Moisturiser AM and a small amount of night cream in the evening before my peptide moisturiser, then I use my red light mask for six mins : ) Hope you're feeling better!!
@@juliafusco6430 I’m not aware of studies showing it isn’t okay but there have been some showing some skincare ingredients like antioxidants can accelerate results.
@@juliafusco6430 If it’s an oil-based product you could always apply it after you use your mask to be sure. I don’t think there’s hard science either way.
@@juliafusco6430 Thanks for sharing this advice. The Maysama serum has oil in it and has been tested for effectiveness with red light so we have some scientific evidence there but it’s not something I would lose sleep over either way.
It is pricey and I just ordered the sunscreen direct from the website and paid a lot in shipping to the UK too. Next time I'll buy a few things at once to make it last!
Yes, and I think Dr Cao was making the point that you only want to go for the medical/pharmaceutical grade MB and be confident of the source. There are other MB options that aren’t medical grade.
Thank you! That's really kind of you to say. My family see me every day so I think it's less obvious, but my mum has said my skin is looking good these days. A few things have come together for me including improving my diet, increasing exercise, taking supplements, small doses of red light daily and a skincare routine that seems to be working out for me.
Hi Clare. I love your excellent content thank you! 🎉 I notice that in your latest routine you’re using an LED light for your eyes - have you stopped using Evensky Venus? I was thinking of purchasing the Venus to help with dry eye and under eye darkness, but also worry the heat will cause fat loss. I’d appreciate your thoughts if you have time to reply. Many thanks :-)
Hi Rosie. I have recently started using an LED eye mask in the morning and love the ease of being able to wear it while I'm doing my exercises. I continue to use the Venus as a more localised treatment for dry eyes but probably only about once a week - it emits a gentle heat. I no longer experience puffiness thanks to changing my pillow, but I use the Venus to help keep the oil glands around my eyes unblocked and find it really helpful for that. Realistically I'm too impatient to use it daily or very frequently long term for eyelid rejuvenation but I've had other viewers say they have got good results. Once commented yesterday that her 11s were markedly improved after using the Venus for a few months. Hope that helps!
@@thehonestchannel I've not heard of this as a dry eye treatment, I'll check it out. I also feel a lot of confusion about the need for eye protection. I wear goggles w/ my panel, but would love to have the RL treat me lids and under eyes. any pointers? Does Venus poo poo the need for eye protection? And as for heat from RL causing fat loss,,, I really doubt it. The heat is minimal and even at home RF devices are supposed to be WAY less heat than in office, supposedly no noted cases of fat loss/
@@cindysmallwood2695 Hi Cindy. Red light therapy has been used to treat eye conditions so it’s safe to use around the eyes for shorter periods of time. I have an RL eye mask that I use for 3min bursts. RF at home is relatively safe but you can’t rule out the risk of fat loss. I have had several viewers experience this unwanted effect. I recorded a video on this issue.
@@thehonestchannel I’m curious what you have done with your pillow? I’ve been at my friends for a week and since being here really having major under eye bags. Maybe it’s the pillow? No changes in habits, lol.
I added MB to my skincare about a month ago. I bought it for a sore throat to gargle with when I had a sinus infection that just wasn't leaving. It would immediately end the sore throat for a half day at a time. Then I had so much left that I added it to my facial spritz that I use before microcurrent. I can't isolate any effects from it on my skin but it's just in the spritz now so no effort to continue including it.
@@vetsai8199 yes, I have to brush my teeth thoroughly after each use. Probably great for my dental health actually. Remember those red pills we used to crush in our teeth in elementary school to learn how to brush our teeth thoroughly? Only this is actually good for you.
@@teresalehtonen8499 I can't remember the specialty website I bought the first bottle from, but I bought the second from Amazon and intend to use them going forward.
I don’t think it’s something Bluelene recommend because they work so differently, but I use a retinal every other night with it and actually think they work quite well together
I have started taking MB for my health in general and my brain health. It stains a lot. How do you put that in your skin care without staining the skin. I still have a few minutes so maybe it will be addressed. MB is also used in fish tanks to keep fish healthy so in the ocean it’s a no brainer.
I use it as a serum before applying a peptide moisturizer at night and use it in the morning after vitamin c and before applying sunscreen. Hope that helps.
She does, if you go to around 24.40 she starts talking about the importance of using medical grade methylene blue if you're adding it to skincare yourself.
