Scleroderma - CRASH! Medical Review Series 

Your videos are amazing as usual, and I love the way this was organized and presented from discussing Limited Scleroderma to diffuse. However, It seems like there are some slightly conflicting complications with CREST syndrome. In medical school and Boards and Beyond, one major complication associated with limited scleroderma is pulmonary HTN and interstitial fibrosis, which is the feared complication and major cause of mortality. This means there is one major visceral organ involved, despite sparing the heart and kidneys (contrast to diffuse).

Scleroderma - *High yield info* - Most sensitive Ab - *ANA* Most specific Ab - *anti-scl 70* - associated with PF & PVD Anticentromere Ab - *CREST* syn RNA polymerase III Ab - *acute onset,scleroderma renal crisis & cancer*

15:40 Bro the action of d pencillamine is it has antifibrotic activity, prevent maturation of new collagen synthesis by preventing cross linking....

Thanks for helping us. You're good!

Thank you for you helpful lectures, doctor! I assume that penicillamine works for scleroderma due to its ability to interrupt collagen synthesis.

D pencillamine works because it interferes with collagen synthesis thus prevents thickening of the skin.

very good videos keep them

thank you.

To understand in basic terms how scleroderma develops.....also known as the pathogenesis..... 1. An etiologic agent causes your immune system's one single leukocyte type to abnormally release autoantibodies into the bloodstream. 2. The excess autoantibodies then attack the bloodstream by causing ischemia, vasoconstriction-induced hypoxia as nitric oxide and other vasodilators in the blood are depleted, and endotheliln 1 and other vasoconstrictors are overdeveloped. 3. PDGF and TGF beta are also produced, worsening current ischemic injury to already damaged endothelium, releasing fibroblasts to numbers out of control, and the fibroblasts release excess amounts of collagen, leading to fibrosis.

Thanks Doctor. I have a question though. If sclerodermal renal crisis behaves like bilateral renal artery stenosis, should we not avoid ACEI?

Who is doctor here

Thank you🌷 itwas very helpfull. How can i have the notes?

Thank you dr

This is pretty outdated information that needs an update

Thanks doctor :)

hello, this is an informative video on scleroderma. my boss was also suffering from this condition. he visited many hospitals but didnt get any relief. then one day he visited planet ayurveda and got sclero care pack. now he is fine and fit. thanks to planet ayurveda

Costa, what do you think about this topic?

Raynaud was a french doc, so the "d" is silent lol.