Fuentes: Thresh J.C. Capsaicin, the active principle of capsicum fruits. Pharm. J. Trans. 1876;7:259-260. Nelson E.K. The constitution of capsaicin, the pungent principle of capsicum. J. Am. Chem. Soc. 1919;41:1115-1121. doi: 10.1021/ja02228a011. Groninger H., Schisler R.E. Topical capsaicin for neuropathic pain. J. Palliat. Med. 2012;15:946-947. doi: 10.1089/jpm.2012.9571. Bishnoi M., Khare P., Brown L., Panchal S.K. Transient receptor potential (TRP) channels: A metabolic TR(i)P to obesity prevention and therapy. Obes. Rev. 2018 doi: 10.1111/obr.12703. Hanson S.M., Newstead S., Swartz K.J., Sansom M.S. Capsaicin interaction with TRPV1 channels in a lipid bilayer: Molecular dynamics simulation. Biophys. J. 2015;108:1425-1434. doi: 10.1016/j.bpj.2015.02.013. Fernandes E.S., Fernandes M.A., Keeble J.E. The functions of TRPA1 and TRPV1: Moving away from sensory nerves. Br. J. Pharmacol. 2012;166:510-521. doi: 10.1111/j.1476-5381.2012.01851.x. Smeets A.J., Westerterp-Plantenga M.S. The acute effects of a lunch containing capsaicin on energy and substrate utilisation, hormones, and satiety. Eur. J. Nutr. 2009;48:229-234. doi: 10.1007/s00394-009-0006-1. Wang P., Yan Z., Zhong J., Chen J., Ni Y., Li L., Ma L., Zhao Z., Liu D., Zhu Z. Transient receptor potential vanilloid 1 activation enhances gut glucagon-like peptide-1 secretion and improves glucose homeostasis. Diabetes. 2012;61:2155-2165. doi: 10.2337/db11-1503. MacDonald P.E., El-kholy W., Riedel M.J., Salapatek A.M.F., Light P.E., Wheeler M.B. The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion. Diabetes. 2002;51:S434-S442. doi: 10.2337/diabetes.51.2007.S434. Zsombok A. Vanilloid receptors-Do they have a role in whole body metabolism? Evidence from TRPV1. J. Diabetes Complicat. 2013;27:287-292. doi: 10.1016/j.jdiacomp.2012.11.006. Basith S., Cui M., Hong S., Choi S. Harnessing the therapeutic potential of capsaicin and its analogues in pain and other diseases. Molecules. 2016;21:966. doi: 10.3390/molecules21080966. Fattori V., Hohmann M.S., Rossaneis A.C., Pinho-Ribeiro F.A., Verri W.A. Capsaicin: Current understanding of its mechanisms and therapy of pain and other pre-clinical and clinical uses. Molecules. 2016;21:844. doi: 10.3390/molecules21070844. Huang P.L. A comprehensive definition for metabolic syndrome. Dis. Model. Mech. 2009;2:231-237. doi: 10.1242/dmm.001180. Ballestri S., Zona S., Targher G., Romagnoli D., Baldelli E., Nascimbeni F., Roverato A., Guaraldi G., Lonardo A. Nonalcoholic fatty liver disease is associated with an almost twofold increased risk of incident type 2 diabetes and metabolic syndrome. Evidence from a systematic review and meta-analysis. J. Gastroenterol. Hepatol. 2016;31:936-944. doi: 10.1111/jgh.13264. Nishida K., Otsu K. Inflammation and metabolic cardiomyopathy. Cardiovasc. Res. 2017;113:389-398. doi: 10.1093/cvr/cvx012. Rodríguez-Hernández H., Simental-Mendía L.E., Rodríguez-Ramírez G., Reyes-Romero M.A. Obesity and inflammation: Epidemiology, risk factors, and markers of inflammation. Int. J. Endocrinol. 2013;2013:678159. doi: 10.1155/2013/678159. Furukawa S., Fujita T., Shimabukuro M., Iwaki M., Yamada Y., Nakajima Y., Nakayama O., Makishima M., Matsuda M., Shimomura I. Increased oxidative stress in obesity and its impact on metabolic syndrome. J. Clin. Investig. doi: 10.1172/JCI21625. Marseglia L., Manti S., D’Angelo G., Nicotera A., Parisi E., Di Rosa G., Gitto E., Arrigo T. Oxidative stress in obesity: A critical component in human diseases. Int. J. Mol. Sci. 2015;16:378-400. doi: 10.3390/ijms16010378. Merone L., McDermott R. Nutritional anti-inflammatories in the treatment and prevention of type 2 diabetes mellitus and the metabolic syndrome. Diabetes Res. Clin. Pract. 2017;127:238-253. doi: 10.1016/j.diabres.2017.02.019. Samuel V.T., Shulman G.I. Mechanisms for insulin resistance: Common threads and missing links. Cell. 2012;148:852-871. doi: 10.1016/j.cell.2012.02.017. 50. Ye J. Mechanisms of insulin resistance in obesity. Front. Med. 2013;7:14-24. doi: 10.1007/s11684-013-0262-6. Faraut B., Giannesini B., Matarazzo V., Le Fur Y., Rougon G., Cozzone P.J., Bendahan D. Capsiate administration results in an uncoupling protein-3 downregulation, an enhanced muscle oxidative capacity and a decreased abdominal fat content in vivo. Int. J. Obes. 2009;33:1348-1355. doi: 10.1038/ijo.2009.182. Brown L., Poudyal H., Panchal S.K. Functional foods as potential therapeutic options for metabolic syndrome. Obes. Rev. 2015;16:914-941. doi: 10.1111/obr.12313. Baboota R.K., Khare P., Mangal P., Singh D.P., Bhutani K.K., Kondepudi K.K., Kaur J., Bishnoi M. Dihydrocapsiate supplementation prevented high-fat diet-induced adiposity, hepatic steatosis, glucose intolerance, and gut morphological alterations in mice. Nutr. Res. doi: 10.1016/j.nutres.2017.11.006. Okamoto M., Irii H., Tahara Y., Ishii H., Hirao A., Udagawa H., Hiramoto M., Yasuda K., Takanishi A., Shibata S., et al. Synthesis of a new (6)-gingerol analogue and its protective effect with respect to the development of metabolic syndrome in mice fed a high-fat diet. J. Med. Chem. 2011;54:6295-6304. doi: 10.1021/jm200662c. Diwan V., Poudyal H., Brown L. Piperine attenuates cardiovascular, liver and metabolic changes in high carbohydrate, high fat-fed rats. Cell Biochem. Biophys. 2013;67:297-304. doi: 10.1007/s12013-011-9306-1. Hochkogler C.M., Lieder B., Rust P., Berry D., Meier S.M., Pignitter M., Riva A., Leitinger A., Bruk A., Wagner S., et al. A 12-week intervention with nonivamide, a TRPV1 agonist, prevents a dietary-induced body fat gain and increases peripheral serotonin in moderately overweight subjects. Mol. Nutr. Food Res. 2017;61:1600731. doi: 10.1002/mnfr.201600731.
Muchas gracias por su dedicación de estudiar para informar. Es muy claro y sencillo el mensaje. Me gustan sus videos desde que lo conocí. Gracias una vez más...🌹🤍✨
Quiero expresar mi profunda gratitud al Dr. Sorio por su dedicación y profesionalismo excepcionales. Su enfoque en el bienestar del paciente es evidente en cada consulta.
Además de su vasta experiencia médica, su capacidad para escuchar y empatizar crea un ambiente de confianza y tranquilidad. Esto hace que cada visita sea una experiencia positiva.
Agradezco sinceramente su compromiso con nuestra salud y bienestar. Su esfuerzo y cuidado han hecho una gran diferencia en mi vida y en la de muchos otros pacientes.
Dr Sorio soy del Norte de México y se consume Chile y pimienta, y la capsaicina es la substancia principal del Chile, substancia P, con potenciales efectos de beneficios a la salud. Saludos y es un programa muy interesante y con lenguaje muy coloquial
HOLA ,QUE TAL ,DR : YO NO CONSUMO PICANTES ,TENGO HEMORROIDES ,INTERNAS Y A VECES EXTERNAS .CHAUUU... GRACIAS TOTALES !!! FELICITACIONES !!! GRACIELA DE LA ARGENZUELA DE MILEI Y COMPAÑIA 🎉
