Thank you for this video! I will be doing Soxhlet extraction for the first time tomorrow and this helped me understand the setup and the working of the extraction.
I would like to know if you can connect a vertical vacuum adaptor between the soxhlet extractor and the condensor in order to work under reduce pressure, thanks, for your video.
is it okay if my extraction solvent does not "siphon off" it just flows down drip by drip...i put 40g of my sample in a 100ml soxhlet ectractor and use 250ml of solvent..do i need to change the amount of sample or solvent?
Thank you very much for the video. Very professional. Question, I am new to distillation/extraction and wanted to know is there an advantage to using alcohol base vs. water and using dry material vs. fresh plant matter. Thank you.
I found these pieces of info to be very helpful: "The solvent selection for isolation of any phyto-constituent depend upon its solubility in that solvent. water are used if nature of phyto-constituents is polar Alcohol is used for if its slightly non-polar (used for both polar and non polar) Non polar solvent like ether and acetone are used for highly non polar solvent." "Factors should be considered when selecting a solvent: polarity; boiling temperature - this should be low in order to facilitate removal of the solvent from the product; reactivity - the solvent should not react chemically with the extract, nor should it readily decompose; viscosity - must be low; stability to heat, oxygen and light; The organic solvents more frequently used are: aliphatic hydrocarbons: propane, butane, hexane alcohols: methanol, ethanol, 2-propanol hydrocarbons with a carbonyl group: acetone, methyl acetate halogen derivation: dichloromethane, dichloroethane, freons."
I have been watching organic chemistry videos on RU-vid for a couple of weeks now, and have now seen about a half dozen videos where this extractor is featured. I'm still waiting for the obvious comparison between a Soxhlet extractor and a flush toilet, but alas... not yet!
First thank you for this demonstration! I need to extract fat from adipose tissue. Do I need to crush the sample before putting it in the extractor? Thank you
HI! I need an advice. I have to extracted lipids from a solid matrix. I used a Soxhlet; I fill the flask with dichloromethan and methanol. At the end of the extraction how can i recover the extract? i have no rotary evaporator in the lab. I think that lipids are dissolved in dichlorometane but both of the liquid solvents are transparent. Can you suggest me some strategy? I was thinking to aspire with a pipet the suspansion but i'm not sure it's is a good idea.
I have a question I see that many people put the solvent directly into the chamber of the sohxlet apparatus before starting the extraction. in this video i see that the solvent is in the round bottom flask which technique is correct or what does it depend on?
Short answer, is it doesn't matter most of the time, the long answer, is it depends on the type of thimble used. When using a glass thimble, with a rosin or cellulose bag, it is probably better to pour the solvent directly into the soxhlett, whereas in this example with the cellulose thimble, leaving the solvent in the boiling flask is more ideal. Overall, the solvent will get siphoned out and cycled regardless, so it the option only really affects the first or second cycle.
so basically, it's kinda like making coffee with a coffee filter, that eventually evaporates the water from the "pot" and then runs it over the coffee beans again?
It depends on the boiling point of the solvent, and the amount of vacuum. He's using a low boiling point solvent, so it only takes a few minutes. You could boil off 100 mL in 10 minutes for sure.
He is not using the fume hood correctly (the door is up), so HSE- requirements are not being met. Please keep the door down as far as possible, especially when working with volatile (and toxic) liquids such as methylene chloride.
Yes and no, I've pondered myself if it's worth the time rather then just dumping some alcohol and your product in a bowl then letting in sit and then filtering it but it's hard to get everything out doing that, depends if you want every drop of your product collected or just 60 percent
I need to cure fistula, I have been suffering for many many MANY years and I REALLY am desperate to get something done at this point, can anyone please HELP 🙏 I'm thinking that this could be used but I have no idea what to use with it, please please can anyone help me, I am NOW DESPERATE X
He used a Rotary evaporator to boil the solvent off. So if you dont want to get your solvent back, just boil it off. If you want to collect it, use a simple destillation. Idk which solvent you used, but most people use butane for it, where you cant really use a soxhlet. There are Videos how to do this then. Search for "making shatter". I asume you live in a state where this is legal ;)
magic wizard man Hi man! I am from The Netherlands actualy, so still illegal :( I am a leukemia patiënt and i want to make my own medical grade oil. I can make RSO now, but i want to step it up so i bought a soxhlet for extration. And it is quitte easy to understand the basics. Bassicly what i want to achieve now is to make a clean as possible product with as less as loss of solvent as possible. The solvent i use is ethanol and that is taxed highly in my country (netherlands) So i am looking for a way to distillate the solvent from the oil and catch it for re-use. Besides that, i produce free thc oil for other cancer patients and give that away for free. So i want to make as clean as possible products, with the lowest costs possible. What exactly is short path distilation, and what other methods are there to use. Bassicly, i saw the video on youtube from Open steel source and Jon Brown and i want to learn that stuff! So i want to learn the tricks, but also the theorie behind it! but i have no clue as of where to start, study books wise.
predjee i only said it so i am on the safe side :D So you can learn good Chemistry "tricks" from Nile Red and NurdRage, they make High Quality Chemistry Videos here on RU-vid. Also ChemPlayer. They also explain many things like mechanism etc. You can use a Soxhlet extractor if you work with Ethanol. After that you distille it off, you will recollect your clean Ethanol then and you can reuse it then. You just need a Heating source, a "Destillierbrücke" (English translation would be Destillation Bridge, but idk if they really call it like that, you can use the german word to google it :D) and a Collecting Flask. That would be the easiest way. Dont heat to high or you will destroy the THC. Ethanol boils at around 78°C, so you know you dont need to go much higher. But i actually think Ethanol is not the best choice. I never did something like a THC extraction, i just can tell you from my experience in chemistry. i think you will get better results with diethylether, it boils of it 35°C, but its actually pretty dangerous in the wrong hands. But i think Ethanol will extract more than the THC, because its also a good solvent for things like Chlorophyll. Also, before you use chemicals, please check the safety data sheets for the chemicals before handling with them. i hope i could help you a bit.
If you are going to do one illegal thing, it won't make much difference if you do another as well ...like making your own ethanol... just don't announce it on the internet!
I am still not sure why you would do this procedure instead of just hanging the nutmeg container into the solution like a tea bag and letting it sit for a while. Other than that, great explaination.
Yes that is why Philippines was colonized for more than 300 years by Spain. They accidentally discovered Philippines when their supposed destination is in Moluccas.
