Specific (Adaptive) Immunity | Humoral and Cell-Mediated Responses

Подписаться 132 тыс.

Просмотров 87 тыс.

50% 1

CORRECTION: What I labeled "CD4+" in the diagram is actually the "TCR," which stands for "T-Cell Receptor." The CD4 glycoprotein is a coreceptor with the TCR, but it's not shown in my diagram.
This is how our bodies learn to identify a new pathogen and develop immunity to that pathogen in the future.
🔬For all my science videos and other resources, check out: www.justinmsiebert.com
💻 My youtube channel: / siebertscience
0:00 Introduction
0:48 A Wild Pathogen Appears!
2:11 Phagocytosis and Presenting the Antigen
3:27 T-Helper Cells
4:29 Humoral Response (B-Cells and Antibodies!)
7:07 Cell-Mediated Response (Killer T-Cells!)
9:18 Recap
11:13 More bad acting...
_____
Image used:
“6VSB spike protein SARS-CoV-2 monomer in homotrimer” commons.wikimedia.org/wiki/Fi..., 5-HT2AR, CC0, via Wikimedia Commons

Опубликовано:

2 июн 2024

Ссылка:

Скачать:

Готовим ссылку...

Добавить в:

Мой плейлист

Посмотреть позже

Комментарии : 127

@halqthedarktemplar 11 месяцев назад

To add a bit to the cell-mediated response for people reading the comments, the infected cell presents the antigen via the MHC-I (instead of the MHC-II of the APC cells) and the T-killer lymphocyte uses the CD8 receptor for that antigen

@naylacalvin2507 2 месяца назад

Thank you it was actually helpful

@user-wx8kv8ty3o Месяц назад

Fantastic lecture and comments.

@chefmittens3056 Год назад

This was insanely precise. I love that you follow such a linear path for something involving a lot of steps at once. Seriously thank you thank you thank you. I've watched a lot of good videos on immunity but yours was the only one to truly make it fully understandable.

@SiebertScience Год назад

Thanks so much for the kind words! Glad you found it helpful.

@user-hv6ow1tu6x 9 месяцев назад

Yes, this is so true thank you😊

@puneet1173 2 года назад

Thank you so much. I have spent hours looking for videos to help me on this topic and now you have made it crystal clear in my head. Please continue to make more videos they help so much

@SiebertScience 2 года назад

Aw, thank you for the comment! Glad it was helpful!

@SyenPie 7 месяцев назад

EXACTLY. This was by far the best video I've found on this topic, presented in such a CLEAR and organized way! This man truly has a gift for teaching.

@flygirlkc 2 года назад

Thank you for the "clear as glass" explanation!

@SiebertScience 2 года назад

You're welcome!

@darianleduc 6 месяцев назад

Thank you so much! Adding the etymology of the cell and biochem names is super helpful

@zygridollero5479 11 месяцев назад

Thank you so much for doing this! I was having a hard time reading about this topic on my own. It made so much sense :D

@chrissvitreoushumour 7 месяцев назад

awesome explanation. you connected the processes of cell-mediated and humoral immunity really well

@heatherkrn5200 Год назад

This is the most helpful video I have seen on the interaction within the adaptive immune system. Thank you for such a clear explanation

@bonner9900 2 месяца назад

The best and clearest presentation !

@TiaDimi Год назад

I have been researching this topic over the past week for an assignment, struggling to find anything as clear and helpful as this video by a mile. This video literally feels like the best video on the whole internet for explaining B cell and T cell functions and specific immune responses in general. The detail is perfect, the whole video flows. Thank you so much, I really appreciate your work!

@arnabray3662 Год назад

Thank you so much for such amazing explanation. Definitely gonna nail this topic tomorrow

@jo_lenin8990 Месяц назад

Super cool video. Thank you so much. You make it straight forward, interesting and deep at the same time. Best doctor here!

@marthaschurr7827 8 месяцев назад

Great video, and such beautiful visuals

@jenniferthomas6592 9 месяцев назад

This was super helpful! Thank you!

@hollyweselowski7442 2 года назад

thorough and helpful, im an NP student and this was SUPER helpful !

@pulkitverma8104 Год назад

Brother one of the finest video on this topic.....you got my respect 👍🏻🤝🏻

@akeminnocentosagie5901 10 месяцев назад

You have definitely help and educate me so so much with your videos. You are the best with the You analyses and make it look very simple to understand. Thank u so much.

@sagaranilkumar8619 Год назад

Oh thanku so much for that wonderful class helped me to understand the topic very much... plz keep going and post more videos..

@v.2435 11 месяцев назад

This is so concise, Thank a lot Prof. !!!

@mondelwane8592 8 месяцев назад

I wish you were making videos 4 years ago, my goodness man you are a life saver

@carlapaperdoll Месяц назад

Bless you! Please continue doing what you're doing! You're an angel

@laurenbaron6820 2 года назад

Thank you so much! Very helpful video. Love the pictures made it much more clear :)

@SiebertScience 2 года назад

You're welcome!

@hamzaha.al-quaid2441 2 года назад

Really awesome big picture video. Thank you🙏🧬

@user-wx8kv8ty3o Месяц назад

Fantastic lecture and comments

@khalidabdulfattahmutwally9286 7 месяцев назад

Extremely beautiful and beneficial. I love that so much.. please continue

@ratanraj743 3 года назад

You are wonderful ... clear and crisp ... wish youtube present u to the needful learners in the manner how our cells present the antigens for betterment of body :)

@SiebertScience 3 года назад

Thanks! I hope RU-vid listens to your advice, haha! :)

@annguy5563 3 месяца назад

This is so amazing, you explain what my 3 hours lectures couldn't in 10 minutes.

@sandyable Год назад

so far your videos have been very helpful:) thank you for making it easier for us. although I didn't believe you were sick :x

@sarahlee3100 5 месяцев назад

Please continue making these videos. Once I learned about your channel, I can't stop watching them to learn more! Very concise and easy to digest diagrams (they are also very cute) Thank you so much

@SiebertScience 5 месяцев назад

You're welcome! I plan to keep making them!

@samanthaagneslumapas8479 Год назад

Big help 🎉 thank you!

@stephaniemiller5165 Месяц назад

I Spent a week trying to figure this out and u explained it in a few minutes. You are truly a teacher indeed. Can you couple this with the Mac 1 and two? Omg you are good. I have hope now of passing this section of the exam tomorrow!

@user-nw4sp1bp5v 9 месяцев назад

Nursing student here! Thank you so much for these videos!! You are a hero!

@user-pc6or2qi2m 11 месяцев назад

thanks heaps for this video!

@taylorguarino1555 7 месяцев назад

Thank you so much for this amazing video

@celinaleal7692 Месяц назад

Love your videos! I'm doing biomed and some concepts I just cant' understand until you explain it. Also, omg I love Cells at Work too!!

@cbri1621 10 месяцев назад

Your videos have single handedly taught me all of the systems that we need to know for the MCAT! I never took anatomy as its not required for us and when I started studying I had regrets on not taking it, but man your videos on the immune system, digestive, respiratory, circulatory and kidneys have literally taught me everything!!! Your videos are so well put together and so easy to follow I hope RU-vid pays you a million dollars a year for your services :) Question about the immune system: So what is the difference between MHC-II and MHC-I? Are MHC-II's only present on macrophages? Seriously thank you x 1000 and I hope to use your videos throughout medical school once I make it there :)

@jennyrios9535 Год назад

Reviewing my Physiology notes to take my TEAS exam. I looked through so many videos that were either too complex or too simple. This was perfect! Loved the artwork and the clean separation of processes. Thank you!!!

@SiebertScience Год назад

You're welcome! I'm glad you found it helpful. Yeah, it's hard to find resources at the right level for a lot of this stuff.

@TP-mv6en Год назад

This is a great video thanks so much for making it

@karl_fischer 11 месяцев назад

I have a class test in 4 hours and now I am fully confident that I'll ace that! Thank you.

@sookieseestruth7573 3 месяца назад

This was the bomb. Thank you

@tiffany6376 2 года назад

I got frustrated learning about immune system, but your video is truly a big help for me to understand it better. Hopefully u will continue making new videos cause I gonna be a big fan of your

@SiebertScience 2 года назад

Glad it helped! I plan to keep making more videos!

@TheTiss1982 3 месяца назад

This man needs a medal for this breakdown! I’m passing this exam! Talk about confidence he just gave me

@NappyZoeRebel Месяц назад

Great video!!!

@lamarjr001 11 месяцев назад

You’re the best!!🏆🔥

@mulukenm268 3 месяца назад

What an attractive and genius way of presenting!! Please continue doing it for other parts of pathology and physiology. You made the subject matter very edible 😀😀😀

@SiebertScience 3 месяца назад

Thanks! I plan to keep making videos 👍🏼

@kimmagri181 2 года назад

Very helpful ! Thank you so much :)

@SiebertScience 2 года назад

You're welcome!

@jonnymercy4528 Месяц назад

best guide ever!

@alperbulut1267 7 месяцев назад

i didnt had a problem with focusing on your lecture. That's rare for me thank you for the video

@elle3947 2 года назад

Took me so long to understand until this short video , so clear :) thanks

@carolinew1616 7 месяцев назад

THANK YOU! 🎉🎉

@rajabumlaluko2897 7 месяцев назад

I found it more helpful and easy to understand

@emersongill8501 3 месяца назад

I'm a very visual learner and the way you drew it all out and separated the different processes! thank you for finally helping my brain understand this topic :) If I get an A on my exam today I can thank you!!

@SiebertScience 3 месяца назад

Glad the videos were helpful. Let me know how you did on your exam!

@vectorie6195 Год назад

Thank you so much

@dejamin876 11 месяцев назад

Many thanks very good video

@Jarh9999 Год назад

thank you sooooooooo much this clicks so well now

@SiebertScience Год назад

You're welcome! Glad it helped!

@eman.hasann3335 7 месяцев назад

U r one of the best youtuberrrr❤❤❤❤❤❤❤

@AnaMishu 2 месяца назад

I always watch your videos before reading a textbook bc most of the time textbook seems very complicated, then I do my quizz assignment with ease

@ethancraeynest4183 9 месяцев назад

very clear and specific video, just hoped you would take about the types of interferones and the "component system" too. This would have helped to be even more complete. Maybe talking about the NK-cells too but overall very very good video

@martashenker 7 месяцев назад

NK cells are part of the innate immune system, that's why they are not being discussed here

@mohammedshamboul3145 10 месяцев назад

Thank you You are good medical teacher I watch in youtube

@JessicaDejesus60 Год назад

wow thank you so much!!

@gellerhockey1213 Год назад

Thank you!!!!

@ddamme05 Год назад

I'm not a Bio major but this is probably the best video explaining anything ever. Helps me understand research I'll have to read for my extra-credit assignment. Thanks!

@SiebertScience Год назад

Best video explaining anything ever??? What a great compliment! I appreciate it!

@allround8771 3 года назад

I've been watching a couple of videos on the Immune System and I could easily admit that you're the Phil Jackson of Immunology. Well, Phil Jackson with a touch of DiCaprio (nice fake acting lol). You've mastered the act of transferring knowledge. Thank you!!!

@SiebertScience 3 года назад

Hey, my students tell me my acting is improving! But they’re probably just being nice... Thanks for the comment!

@HamedAlqahtani Год назад

thank you so much

@mollygrigg7005 Месяц назад

I watched the lymphatic system video and now this … and I want to watch the blood one next. For the very first time I’m finding human body systems fascinating. Never had such a great teacher before. I might have gone into medicine if I had had videos like this in my younger life! Now I’m going to use them to teach my kids!

@SiebertScience Месяц назад

Aw, thanks for the kind words! Best of luck with homeschooling anatomy this year!

@victormulenga4690 2 года назад

wonderful and help tutorial, I like it

@SiebertScience 2 года назад

Thanks for the comment!

@milliecroft1200 2 месяца назад

I dont think ive ever commented on a youtube video in my life, but this was so helpful i almost did a backflip out of joy, thanks !!!!!

@Heh18287 5 минут назад

thanks you for this AMAZING explanation, and you should definitely be an actor😂

@MdR15 Год назад

Just Excellent💯💯

@SiebertScience Год назад

Thank you 🙌

@user-ck8qz6yb6n Год назад

100% perfect🤞👏👏clear and understandable ♥️

@SiebertScience 11 месяцев назад

Thanks so much!

@osamaelessawy4796 6 месяцев назад

thank you

@mangajunction8762 Год назад

This is good ✨

@SiebertScience Год назад

Thanks!

@croys8608 2 месяца назад

Thank you,

@evamaryanti800 3 месяца назад

Not so convincing coughing, but the lecture was amazinggggg. Thanks!

@SiebertScience 3 месяца назад

So you’re saying I shouldn’t quit RU-vid to become an actor??? ;)

@aggelikinakou_ Год назад

oh my god, thank you so much for this video, immunology is driving me crazy

@Ahmad_Fawaz Год назад

Can you make vd about the non-specific?

@grrrrr219 2 года назад

hataraku saibou in the background! It's a good show focusing on body immunology ! 😄

@SiebertScience 2 года назад

I was hoping some people would notice that! Great show!

@eman.hasann3335 7 месяцев назад

Thank uuuuuuuuu❤❤❤❤❤❤❤❤

@medianayaseen1610 11 месяцев назад

I have a question regarding the B cell maturing in the bone marrow i read in multiple sources that it start’s developing in the bone marrow but continues in the spleen to final maturation but i also read it matures in the bone marrow so can you tell me which is true?

@trinityg8511 4 месяца назад

the best video to explain this. I really wanted a clear cut, step by step demonstration and this is incredibly helpful. thankyou!

@prernapatil6458 Год назад

can you just clear a doubt ? How can cells retain specific memory of any pathogen in spite of having average life span?

@karl_fischer 10 месяцев назад

they keep dividing into new cells and passing on the information.

@JarodKientz 3 года назад

I like the Cells at Work easter egg.

@SiebertScience 3 года назад

Yeah, I just discovered the show last week! So good!

@Yo_Thenics Год назад

What about MHC 1 that present the antigen for T cytotoxic?

@teresap8428 6 месяцев назад

The intelligence of our body

@VennelaReddy-fj3st 14 дней назад

this guy made my life a lot easier

@bili4591 Год назад

The problem is, everybody start to modify the truth at the moment of the cross between innate and adaptive immunity so I can’t know what is real or not real ... - The T helper cell learn the shape of the antigen presented by the APC and goes on ? OR - The T helper cell have already learn a antigen specificity at the birth and goes on only if himself and the APC match ?

@andreasvanbrusselen3802 Год назад

Goat

@triggeredbiology4726 7 месяцев назад

This is for class 12??

@justgremoryy2148 4 дня назад

Cells At Work!! i love that anime!

@szxnv Год назад

goated

@alvinsun2346 Год назад

very helpful, especially when you have a teacher that doesnt do her job

@SiebertScience Год назад

Thanks! Glad you found it helpful. Yeah, a bad teacher makes it tough, but as a student you have to find what works for you! (such as finding RU-vid videos)

@haley3730 9 месяцев назад

APC: the body’s way of wearing the blood of our enemies 😂 Those cells literally decapitate the invader and WEAR it’s body to alert other cells!! How cool is that!!!

@samanthadebruin1467 2 года назад

would Humoral mediated immunity be how we build immunity through vaccines???????///

@SiebertScience 2 года назад

There are several different mechanisms for different types of vaccines, but understand this type of immunity is kind of the first step in understanding how those work.

@johnyannelli2480 7 месяцев назад

I would be very careful if you listen to this and use it to learn immunology. It is oversimplified. For example, CD4 does not define specificity nor does it recognize antigenic proteins. This is mis-leading. Be careful.

@SiebertScience 5 месяцев назад

Thanks for pointing this out! I added a correction in the description: "CORRECTION: What I labeled "CD4+" in the diagram is actually the "TCR," which stands for "T-Cell Receptor." The CD4 glycoprotein is a coreceptor with the TCR, but it's not shown in my diagram."