Steady states and the Michaelis Menten equation | Biomolecules | MCAT | Khan Academy

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Created by Ross Firestone.
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4 июл 2024

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Комментарии : 229

@azuansofian2822 4 года назад

he keeps on slapping me with these letters and i dont wanna live no more

@storm7063 3 года назад

same dude, i am going to live in a box

@walkerwatters8607 Год назад

Need an update buddy, how are you doing two years later?

@HasanJawhar-dl9rn 4 месяца назад

did you pass biochem ? @@walkerwatters8607

@anau.1122 2 месяца назад

you can say I'd KM[S]

@Lovely-bh3ln 29 дней назад

I love this comment thread ive been laughing at them for 10 minutes now 😭😭😭😭

@amyheart5567 Год назад

ahhh..... 3 weeks of lecture condensed in a clear and organized manner into 7 and a half minutes. Thank you so much.

@winterbabyXOXO 3 года назад

Tip: put the settings on 0.75 playback speed, and pause every time he writes a new line, making sure that you understand the logic of how he got there

@w00tplayaw00t 8 лет назад

I learned so much more from this video than from reading an entire chapter two times. -.-

@ChimeraGilbert 6 лет назад

But perhaps reading the chapter helped you understand the video!

@gomamon15 5 лет назад

Exactly the reason i am here. Read the chapter and helped a little but the video tied it together.

@dorianl.210 2 года назад

generic comment number 2314423

@littlesnakeuu413 4 года назад

dude THANK YOU! I've been reading my notes over and over again and still quite lost in the derivation. You explain it quick & nice, I finally understand it. honestly i don't think it's too fast or anything. i kinda like the pace cause I tend to lose focus if the vid is too slow or long

@arsallansiddiqui9106 10 лет назад

Usually i love your videos Ross, but seems like you rushed this one a little too much ! it was very complex indeed!

@sasisarath8675 4 года назад

Complexity is just more layers of information. Chinese is more complex than English. Everything is relative.

@InceptionSolver1 9 лет назад

This is significantly more helpful than listening to my biochem teacher haha

@dorianl.210 2 года назад

comment number 232359

@carlmariepebenito2664 2 года назад

same here lmao

@martinstanchev1432 2 года назад

THIS!!

@emkay7233 6 лет назад

OH. MY. GOD. literally what ive been trying to understand in past 7 hours has been summed up in 7 minutes. I LOVE YOU.

@amberants 6 лет назад

THANK YOU!!!! Rewatching my bichem lecture three times, and attending two tutorial classes i thought i was never going to learn this. its so dang simple when you explain it. THANK YOU!

@Dizzifizz 6 лет назад

Perfect video, literally. Well paced and so informative. Breaking concepts down too much can often cause complications hence I love the well paced style of teaching by this educator.

@saarkoene2761 2 года назад

Very usefull! Taking a course on enzyme dynamics next semester and need to know michealis menten kinetics but never learned it. I feel like this video will really help me!

@sccm100 4 года назад

Desired speed Sal: 2x This guy: 0.75x

@jessicahoff8574 4 года назад

sebastian cuello painfully accurate

@vodanh7514 4 года назад

8 min video >> 45 mins in class. Thx, really appreciate ur work

@knucklescapricorn31 9 лет назад

Thank you so much, this was very helpful. I never really understand Kcat since a lot of sources just focus on defining Vmax and Km. Cheers :)

@thegigisup7 4 года назад

THIS WAS AMAZING! AS A CHEM E STUDENT WITH LITTLE TO NO EXPERIENCE IN BIOLOGY, I THANK YOU! :D

@Jonathan-rf5cp 5 лет назад

I like this. My only problem with it is that Km is defined in terms of S. Km is already defined by the rate constants of the individual reactions (k1, k-1, k2). Probably more accurate to say that *when* [S] = Km, Vnaught = Vmax/2. edit: rather than the other way around, let Km = [S]. Semantics but conceptually clearer this way.

@apolospetertai6506 Год назад

This video helps me to understand some of the concepts that is critical in my studies. Thank you to Ross Firestone to create it. I also thank my lecture Dr. Missa for encouraging me to watch this video. Much appreciation.

@amateurphilosopher2307 7 лет назад

This makes so much more sense. Thank you so much!!!

@269Tanya 9 лет назад

OMG, YOU DO NOT KNOW HOW MUCH YOU HAVE JUST HELPED ME! THANK YOU SO MUCH!

@Davereal8822 Год назад

Ain’t no way this video actually that good that it clearly brings together my book, notes, and other vids

@mohamedwael2026 6 лет назад

great...I was struggling to understand it in my lecture but now I find it easier and more clear ..thanx 👍🏻

@irinikobold1084 4 года назад

dude we had this class at my uni, and even tho the biochem professor said the exact same things, somehow you made them understandable in comparison to what he said. And English isn't even my mother tong. Thank you very much for this helpful video plz dont ever stop

@tinieblas6429 4 года назад

You helped SO much, thank you for the wonderful explanation!!

@maryambaj9901 9 лет назад

Thank you so much !! This was absolutely helpful :)

@nourkamaly9496 5 лет назад

This is the first time i've ever found the khan academy videos not helpful, you're going way too fast dude!!

@jessicahoff8574 4 года назад

Nour Kamaly same and it sounds awful when you slow it down. Rather have the option to speed up the video. I’m sure it would be a wonderful video if it wasn’t already sped up.

@HariKrishna-nt6rc 4 года назад

it is very helpful . u should see manytimes to get it clear..

@soleegaming3201 4 года назад

It's seem the result (the understanding of the explanation) is different for different people...

@sasisarath8675 4 года назад

To me every khan academy video is slow I totally avoid the whole thing and just code.

@YZ_KRaZee 3 года назад

Check once again...you would've probably set it on 2X 😂

@kw_2707 Год назад

Thanks for completely writing all the steps of the equation out. I never understand formulas/equations unless it's actually shown WHY it is the way it is

@srishtikhurana4487 2 года назад

This video saved me from getting a panic attack. Thank you do much for explaining it so well.

@Healthtips-mv6kn 9 лет назад

My bio chem teacher took 2 hours to explain this! LoL

@janakhabouri8271 6 лет назад

This video is good and condensed and DAMN BLESS YALL

@sadachalk3150 8 лет назад

Slow down!!!! I usually love your videos but this is way too fast!

@zekeg9893 9 лет назад

literally none of this makes sense to me.....

@ukno918 7 лет назад

Review chemical kinetics

@elizabethvelma266 Год назад

😂me too!

@mary.b92 4 года назад

I've never understand it before watching this video, thank you a lot

@applejackzo 7 лет назад

Visual learners across the globe thank you for this video.

@nabie981 4 года назад

thank you! It was a bit fast but i loved to stop and rewind! ^^

@Hayley1234356789 8 лет назад

Thank you so much! This was so helpful.

@alfi991 9 лет назад

You should be clear that KM is an equilibrium constant hence the upper case K and kcat is a rate constant therefore a lower case k, here you don't show that and it's a very important fact when you takes these things further.

@megha7564 9 лет назад

please answer this: why did we only consider k2 for calculating reaction rate! ie v0 in vo=k2[ES]

@dma67111 5 лет назад

you just simplified an entire 8 pages of derivation thank you

@parakhmody1413 10 лет назад

Please answer this question at the earliest, if possible: Are "V" (the one you introduced in the beginning of the video), and "Vzero" (the one you started talking about halfway through the video), the same thing?

@MichaelH3948 10 лет назад

V = reaction rate V0 = initial reaction rate (reaction rate when time=0)

@PepsiT98 5 лет назад

Thank you for breaking this down!

@KiranJagtap5050 6 лет назад

Really useful! Thank you so much!

@zuhayousuf9197 5 лет назад

Love this video so much. Thank you!!!

@omarmahmoudofficial 9 лет назад

2:12 - 4:50 wtf happened -.-

@EduardoMartinez-fk2pv 5 лет назад

Ace Case you need to know a little of kinetics first, the speed of a reaction is v=K*[R]. R being the concentration of the reactant and as a correction factor they add a K

@ledinah6039 5 лет назад

math

@blitebeats 4 года назад

lmao

@Boo-tw4xd 4 года назад

Ifkr?!

@sagestation7831 4 года назад

You should watch the first video to this series. In addition, the Michaelis Menton equation is used to describe rates. You should know what rates, and kinetics are (usually taught at the end of Chemistry as Chemical Kinetics) to understand what a K value is. You can have a whole 2 hour lecture on what K values are. For this video, just recognizing that it's a constant is sufficient.

@Somenath_Sen 8 лет назад

wow that's really a lot of information in 7 mins. Awesome video.

@rimse272 5 лет назад

THIS WAS SO HELPFUL THANK YOU THANK YOU THANK YOU

@subhanazaan3041 9 месяцев назад

Thank uh soo much, I read lots of notes but cant understand derivation abd concept but now its all are clear just bcz of uh jazak Allah Khair

@HoangNguyen-js3ot 9 лет назад

Amazing! Thank you very much

@joshb4025 6 лет назад

Fantastic explanation, best I've watched

@torvoldsvenson1539 8 лет назад

The old format where the videos were in real time on a black background were so much easier to learn from. These videos that are in fast forward are good for review but way to fast to learn something and there is no time for the detailed explanation that makes it memorable....

@shadibarghout1313 3 года назад

I see a lot of people complaining but honestly let's just thank him for doing this for free, the video is more than ok if you know what each term means.

@deathrat 3 года назад

to anyone out there: WATCH IT AT LEAST TWICE

@christophergoudarzi9992 Год назад

Really helpful videos, thanks so much!

@nathanrumpf5660 8 лет назад

Very helpful. Thank you

@alsinbad3772 8 месяцев назад

k cat is actually just k2, I love it when biologists just name the same variable with diff terms so that the math part can look complicated.

@Mark-ht1ed 6 лет назад

Beautifully explained.

@JAMScover1 4 года назад

This is so helpful thanks!

@manwaiwong1774 9 лет назад

Thank you very much!

@shwetadongre4847 4 года назад

Short n sweet video ,just perfect

@Yeeeeeehaw 6 лет назад

Thank you very much ! very useful video

@jessicabehnam3207 7 лет назад

thank you. this helped alot

@JanelleMontano 9 лет назад

Thank you so much!

@johngrey1074 6 лет назад

The math/derivation is beyond the scope of the MCAT.

@witchkingofa 6 лет назад

Awesome video man, keep it up.

@saileshkrishna8013 5 месяцев назад

Absolutely brilliant ❤

@diabolowho 4 года назад

thanks for the explanation!

@duncanjones2272 6 лет назад

Nicely explained/derived

@aze90 9 лет назад

Future of education!!, so much better than readling the long boring books where the author is probably paid per page written.

@MrNailbrain 4 года назад

Very helpfull despite having to pause a lot.

@arieldroger5291 6 лет назад

Usually have to watch videos on 2x speed, not here! Thank you!

@dimahaddad7664 6 лет назад

Thank you... Thank you.... Thank you ❤❤❤

@jhlee9634 5 лет назад

I have a question! Why does steady state assumption only apply to enzymes, not to inorganic catalyst? I understood this that inorganic catalyst has rate-determining step, but enzymes don't. Why do enzymes don't have a slow step? Is it because of the structure of enzymes? It would be really helpful if you could answer me!

@sophmiester 7 лет назад

If you're here for MCAT review, you can ignore the "lets do some math" section where he derives the equation.

@holmspeterson7544 3 года назад

Excellent explanation.

@user-oy3td7ui6i 11 месяцев назад

واقعا خیلی خوب توضیح داده شده ممنونم❤

@maryamrahmannia4812 4 года назад

Great job

@njay7246 6 лет назад

Thank you very much for the video but why do you make Km=[s]. Isn't Km a constant?

@hammadahmad920 6 лет назад

Good to see a brother muslim Helping the students all over the world Allah is great

@artyomstrelnikov8549 8 лет назад

thank you very much))

@AK-di4rv 7 лет назад

Although this video is fast, if you follow him and pause it and rewind at your own pace it is not that bad. The reason you want your Km to be low is when looking at the graph it has a linear form at the bottom which means your substrate is low and the enzyme as great efficiency hence the linear characteristic of the graph. Then as the substrate increases the efficiency of the enzyme goes to zero as shown by the graph going to zero velocity.

@bkzwolf 2 года назад

The one logic gap that I continue to struggle with is how is the FORMATION of ES equal to the LOSS of ES AFTER the elimination of K-2. You no longer have the breakdown of the Product (which does make sense, given the stability of it) but then that's an entire source of ES production that isn't there!!! So you have 2 routes out of ES (formation of P and breakdown of ES to E+S) and 1 route to ES(formation of ES from E+S). Still holding the initial belief that was applied to 2 routes out and 2 routes to. The only way I can sort of make it make sense, but not confidently, is at the beginning of the reaction where K1 and K-1 might hold more weight than K2 but I'm not sure I'm right with that idea.

@juliazsommer Год назад

I know this comment is old but I think ES stays constant even after elimination of K-2 because there is so much substrate that when ES forms P and the enzyme goes back to being E, it finds another S so quickly that it almost immediately forms another ES

@wafasaliha1552 7 лет назад

just thank you

@parakhmody1413 10 лет назад

Please answer this question at the earliest, if possible: Would it be fair to say that the dissociation of enzyme substrate complex (to product or back to substrate) is a first order reaction, and the formation of the ES complex (from substrate) is a second order reaction?

@MichaelH3948 10 лет назад

That is correct however, as [S]>>[E] k1 (E+S = ES) can in practise be considered a first order rate reaction as the overall concentration of S changes very little over the course of the reaction (The reaction is only really dependent on the concentration of the enzyme). It's what is known as a "pseudo first order rate constant"

@jojowa4196 7 лет назад

really good video! :) But what exactly is k_1, k_(-1) and k_2? are they constants for the time it takes to form the new state? (say, it takes 3s to form ES from E and S, so k_1 = 3s?)

@muntahanoormuskan6431 Год назад

These are rate constants. Rate constants are obtained by dividing product concentration to the power of their stoichiometrical coefficient by substrate concentration to the power of their stoichiometrical coefficient. Rate constant has no specific unit, it changes with the reaction. (Correct me if I'm wrong, learned that 5 years ago)

@marknjama9634 2 года назад

Thank you so much

@livelaughsalang6013 3 года назад

Me checking to make sure my video was at normal speed 😂. But thank youu, good explanation just had to watch it couple times.

@maryamrahmannia4812 4 года назад

Thanks a lot , u saved me

@user-qi4df3uz2l 5 лет назад

This guy is way better than my biochemistry professor

@user-ej1nj5ry6l 5 лет назад

ㅇㅈ 대학 수업들을필요 없음 유튜브에 치면 판때기하나놓고 설명 오지게잘해줌

@jannahalotaibi9728 3 года назад

Do I need to know how to derive the equation for the MCAT?

@zia-ur-rahimazadofficial 6 лет назад

very helpfull really

@dylanbinu10352 6 лет назад

Wasn't exactly able to follow the derivation of the formula to the fullest but everything else was extremely helpful. Definitely not for beginners though haha. Read the textbook first, guys! Or watch a simpler video

@sabissu5965 4 года назад

I think it was very helpful, I don’t understand why people r saying that it was too complex or fast. The subject is not an easy one and you don’t have to know all of the steps for the last formula. And you can still watch it again or slow the video down.

@jackarcher5685 5 лет назад

Is kcat = k2? Can you please explain how you derived it?

@reshmi5333 6 лет назад

This is the second time I am watching this video.in 2014 I was so naive.now I understand everything now.lol I was such a fool

@tamerdoc401 10 лет назад

V = K [ES] so V is concentration unit mol / liter or what??? and if so is Kcat is M/M so it is Number/second?

@gillesbaumann675 7 лет назад

amazing video! Really good explaind?! Thanks a lot !

@mohsinkashif3674 8 лет назад

you are great

@tenzinphuntsok1 6 лет назад

quick question, why the lower the Km value better is the enzyme while the higher Vmax is better ? since Km =Vmax/2, higher Vmax leads to higher Km.. isn't it ?