In this video, I follow another procedure from Vogel on the Friedel-Crafts acylation of toluene with acetic anhydride to produce p-methylacetophenone. Music: Serenade for Strings, Elgar
Oh so cool! I love the quality and procedures in your videos! Very interesting using acetic anhydride instead of acetyl chloride. I'll have to try this as I have a good quantity of acetic anhydride that I need to use. I bought it thinking I'd use it alot but actually haven't cracked it open 1 whole year later!
How? I just looked at the structure of mephedrone and its acetophenone with the alkyl chain extended, branched, and aminated. It seems like a bad starting point.
What do you mean due to the loss of vacuum in the system? Dont you keep the vacuum pump running during the distillation? Or do you pull the vacuum, close the system then run the heat to distill product? I always thought they say to keep the vacuum pump running during the whole process and have a vacuum constantly pulling on the atmosphere inside the system? Im confused lol
@@BackYardScience2000 the part two of that video had to go on the back burner since the material I was trying to analyze was amorphous. Makes XRD a little difficult. But I’m setting up a new lab that will be dedicated to more videos. Setting it up is the next two months of my life though haha.
It would be very useful for you if you could hook up with someone who can run an nmr for you. That would take out all of the guesswork about the identity of your products.
I believe the abnormal boiling point during the vacuum distillation is the result of my pump heating up considerably as it runs, this would increase the vapour pressure of the oil and whatever solvent impurities that have been captured in it. So as the pump runs, it heats up the oil, increasing the vapour pressure of the oil, increasing the pressure in the system, increasing the boiling point, and this would happen slowly over time as the pump slowly heats up. That's my theory.
Thank you for that information. But, could this reaction be done by a substitution of benzene for the toluene and acetyl chloride for the acetyl anhydride to yield acetophenone instead of the p-methylactophenone?
@@martinheidegger1125 Yes. You can do that. Acetyl chloride is also very good reagent. But consider two things Acetyl chloride is highly toxic. And if you use acetyl chloride the by product will be HCl (a strong acid), in case of acetic anhydride it results in acetic acid as the by product (weak acid). So for acid sensitive reactants acetic anhydride is better. Also, HCl is more toxic compared to acetic acid. So reactions with Acetyl chloride should be done with care .
@@yogi5752 apakah dia membohongi kita dengan tayangan ini ? Apakah jika kita mencobanya akan terjadi ledakan . Atau memang tayangan memang benar cara membuat p2p
One time I saw one old secondhand book in a book shop’s in Northern Iran- Rasht, written by a professor( i think the writer was French or American, im not sure), the content was about dozens test guide with pictures about making many different kinds substance, compounds..which in this day’s you can’t find in internet or google.. like extracting HCN from Bitter Almond.. The descriptions was so simple and clear, unfortunately I decided to buy it later cos it was expensive and most worse i did not take a note about writers and the name of book..
whats a name of glassware for collecting different fractions which no need disconnecting them(i mean about end of liebig condenser)? Sorry for little offtop guys and thx for your help
__Flat-bottomed flask under vacuum__ - PLEASE! DON'T DO THIS ANYMORE! Even NO vacuum filtration! For vacuum filtration we have Bunzen thick-walled flasks.
No way. I mean you cannot use it directly. But, There will be reactions by using Acetic acid and some other uncommon catalyst (refer green chemistry journals). But most of the times yield will be very low.
Question: Is this how it goes for you kids? You're at some school at insert random U.S. university and one lucky rando from class gets to, "create a youtube" channel that pertains to chemistry? Like do you all have to draw straws and the lucky one gets the worm or is it like The Price Is Right from back in the tube T.V. days and someone inevitably gets the score by one point? I mean, right in lab class it would seem....
