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T Cell Activation and Control 

ClevelandClinicCME
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Dr. John Looney reviews T cell activation contributors, T cell antigen recognition, and T cell "braking."This webcast is part of an interactive online series designed to bring you, the busy clinician, up to speed with the remarkable advances occurring every day in the field of basic and clinical immunology.
To learn more or to claim CME credit, visit www.ccfcme.org/...
This CME activity was produced by the Cleveland Clinic Foundation Center for Continuing Education and the R.J. Fasenmyer Center for Clinical Immunology.

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29 сен 2024

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Комментарии : 98   
@marcelfab1657
@marcelfab1657 2 года назад
Very well explained. Helped me to study all these modern therapies like PD1 and CTLA Inhibitors. Thanks!
@chintomendoza
@chintomendoza 9 лет назад
What an ammazing topic.....This lecture ROCKS!!!
@johnsong7503
@johnsong7503 7 лет назад
Excellent lecture presentation! Thank you!!
@arinarakhteenko579
@arinarakhteenko579 4 года назад
Awesome summary and nice examples from culture or nature to keep some point in mind thank you!
@billytheweasel
@billytheweasel Год назад
Thank you for this.
@45th_is_47th
@45th_is_47th 11 лет назад
This video really help out a lot
@mrsoluwaoseunti
@mrsoluwaoseunti 8 лет назад
Thank you!
@chrisli9685
@chrisli9685 4 года назад
OMG, TY for this!!!! It summed up perfectly what I needed to understand!!!
@caitlinriggs3433
@caitlinriggs3433 11 лет назад
how do activated T cells know where to go after they have been activated in the lymph node?
@slehbenhamida3689
@slehbenhamida3689 7 лет назад
chemokines secreted by dendritics cells lead the way towards the infected tissue.
@Enes-ld7gk
@Enes-ld7gk 4 года назад
by chemokines ofc
@evagold5221
@evagold5221 9 лет назад
what about infected Mph and DC? Can they make a presentation antigen for T CD8 ? Are there MHC I on DC and Mph or just only MHC II ? Thank you
@evagold5221
@evagold5221 9 лет назад
+Gukan Sakthivel Thank you for answer! Other one thing surprise me: is it really APC have CD4? For what it?
@evagold5221
@evagold5221 9 лет назад
+Eva Gold thank you ! but very often i read about the HIV infects all CD4+ cells =APC !
@svoidkugan
@svoidkugan 9 лет назад
+Eva Gold No No CD4 cells are T cell CD8 cells are T cells too both are T cells ! HIV infects T cells!
@evagold5221
@evagold5221 9 лет назад
+kugan svoid Thank you! But why everywhere written about HIV 1 infects Mph by way CD 4 and CCR5?
@evagold5221
@evagold5221 9 лет назад
+Eva Gold This is from Robbins textbook: The requirement for CD4 binding explains the selective tropism of the virus for CD4+ T cells and other CD4+ cells, particularly monocytes/macrophages and dendritic cells. Binding to CD4 is not sufficient for infection, however.
@romaissach497
@romaissach497 5 лет назад
I just needed to link everything together and this lecture helped me with that, very simple and clear, thank you!!
@Tracertme
@Tracertme Месяц назад
I was delighted to find this video, I am not a doctor or medical student, I am over 60, in a high risk group, according to science, and taught myself everything about these very cells during COVID and active/innate immune systems that I could, and decided not to be vaccinated. I applied science with nature and was only sick for 4 days with omicron BA2. I have never been sick since and continue to build my own health outside traditional medical practices.. I have never been as healthy as I am now, the COVID lockdown period was a blessing for myself, I studied and learned 😅
@Mr22ogins
@Mr22ogins 10 лет назад
Seriously well put together video. Top notch!
@calebhaines3794
@calebhaines3794 3 года назад
Lasers can be used to identify materials that are coorelated with shredding and heating settings on recycling systems.
@so-oo6ti
@so-oo6ti Год назад
I am curious about the radioactively contaminated water that Japan is trying to discharge.
@GPanos22
@GPanos22 7 лет назад
Amazing explanation. Clear and informative!
@zethuandisiwe4188
@zethuandisiwe4188 2 года назад
A very good explanation but how is a picture of a person indicating HIV
@svetlanasoloviova2418
@svetlanasoloviova2418 9 лет назад
You save my life tonight, so much thank you
@rahelnyarko-morrison9354
@rahelnyarko-morrison9354 4 года назад
Lol
@frankieannholmes1892
@frankieannholmes1892 7 лет назад
So very clear and WONDERFUL ANALOGIES--what better way to show antigen recognition and binding than lovers? And the tides in Nova Scotia representing the ebb and flow of the immune response. And all the incidental references to the diseases that are explained by immune overstimulation or exhaustion. What a brilliant and Renaissance man. I need to view this many more times. THANK YOU for making this available
@RiDankulous
@RiDankulous 2 года назад
I watch Twiv (This week in virology) podcast and these mechanisms are discussed a lot. This is very easy to watch, and interesting thanks.
@billytheweasel
@billytheweasel Год назад
TWIV is good too!
@doctorrajeevkn3599
@doctorrajeevkn3599 4 года назад
This is a fantastic class. Everything explained. The secret of check point inhibitor in oncology revealed
@shreineraly1684
@shreineraly1684 6 лет назад
It is primarily explanation but we need to connect that with the clinically associated explanation
@RiDankulous
@RiDankulous 2 года назад
I wonder how Dr. Looney feels about having highest number of views of all channel videos, including more than Dr. Esselstyn (my hero!). I wish both the best.
@spldrstudtom
@spldrstudtom 10 лет назад
Very helpful, thank you very much!
@gabrielbrill4782
@gabrielbrill4782 4 года назад
at 5:05 he mention how t cells get activated in the lymphatics, but a predominant amount of t cells get activated in the thymus and mTECs. I think some treg cells get activated in the periphery such as the lymphatics.
@nope.13
@nope.13 10 лет назад
Excellent! Thank you so much!
@AlexanderKubik1993
@AlexanderKubik1993 6 лет назад
This dude has a stellar mustache though, props to him hahaha
@chandybundy2667
@chandybundy2667 9 лет назад
Ure so much better at explaining this than my lecturer was. Thank you so much
@claricecataldi7555
@claricecataldi7555 3 года назад
I need the conctact with this doctor please.
@0sama789
@0sama789 2 года назад
A great lecture, thank you so much!
@magicuba
@magicuba 8 лет назад
dr. John is a real boss, respect
@oibal60
@oibal60 2 года назад
Thanks for this.
@thyowen
@thyowen 6 лет назад
great video. really clear and moves really well into what it can mean for future developments. explains why its interesting haha, thanks
@hildavalerolozano7752
@hildavalerolozano7752 2 года назад
Gracias , me queda la idea de la complejidad del sistema inmune
@jennamore5514
@jennamore5514 8 лет назад
Very good lecture, thank you !
@zannatul23
@zannatul23 7 лет назад
ayy ;)
@sapnayadav-rc1ym
@sapnayadav-rc1ym 4 года назад
thanks a lot sir for explaining it all so nicely....
@toulinma6916
@toulinma6916 4 года назад
do activated t-cells PERMANENTLY release Cytokines even though no antigen binds to its T-Cell-receptor???
@chrisli9685
@chrisli9685 4 года назад
No, they don't permanently release cytokines. That is why you have CTLA-4 to down regulate the response along with IL-10 and TGF-beta. It is a HIGHLY regulated system. However, there are times it does go wrong.
@tatendagucci3293
@tatendagucci3293 3 года назад
this is really helful
@kenhayes9718
@kenhayes9718 Год назад
Thank you for the time to explain this material so well.
@theequaliser8026
@theequaliser8026 3 года назад
I wish you could help those with celiac disease surely
@faithfoi1303
@faithfoi1303 3 года назад
well done! thanks Dr!
@avinashselva9636
@avinashselva9636 3 года назад
It was a very good lecture. Thank you sir.
@darkaction123
@darkaction123 3 года назад
beautiful
@claramarques5606
@claramarques5606 3 года назад
amazing
@analasic1823
@analasic1823 3 года назад
Thnk you! Great repetition material!
@jeffreyleikachon1
@jeffreyleikachon1 11 лет назад
Thanks, it helps a lot.
@zakirzak1494
@zakirzak1494 Год назад
💗
@zhussipbekmukhatayev7225
@zhussipbekmukhatayev7225 6 лет назад
This video helps a lot! Thank you Dr.John Looney
@solomondo3490
@solomondo3490 9 лет назад
How can I download these videos of interest??????? help!!!
@AlexanderKubik1993
@AlexanderKubik1993 6 лет назад
Solomon Do you go on google and search how! You’re a smart one! (Sarcasm fully intended)
@scottslomka240
@scottslomka240 3 года назад
Creatine prevents exhaustion
@MsAmour2009
@MsAmour2009 8 лет назад
Great job, thank you very much!!
@MsAmour2009
@MsAmour2009 7 лет назад
GREAT JOB! thanks a lot!
@becizaistrup2920
@becizaistrup2920 7 лет назад
Very detailed and well explained
@guillaume6373
@guillaume6373 3 года назад
Awesome talk
@drsharafathali4043
@drsharafathali4043 7 лет назад
Thankyu very much
@rashmivinayak8377
@rashmivinayak8377 10 лет назад
Excellent Talk..... Very very clear concepts..!!!
@AlexanderKubik1993
@AlexanderKubik1993 6 лет назад
Rashmi Vinayak I thought it was very very very clear, not very very clear, didn’t give it enough credit
@jiayuho3459
@jiayuho3459 5 лет назад
Thank you so much for the great lecture!
@jaggaiahnaidu4949
@jaggaiahnaidu4949 4 года назад
Good lecturer
@Macroautophagy
@Macroautophagy 10 лет назад
Excellent talk
@sivasankarnallapati
@sivasankarnallapati 3 года назад
Love it
@김수빈-m6m
@김수빈-m6m 5 лет назад
Thanks😊
@kingpat345
@kingpat345 11 лет назад
Nice video
@jiafengxu3126
@jiafengxu3126 10 лет назад
thanks
@davo3299
@davo3299 11 лет назад
chemokines!!
@richardnevin
@richardnevin 10 лет назад
Thanks
@vivekbhore8558
@vivekbhore8558 11 лет назад
Good
@vivekbhore8558
@vivekbhore8558 11 лет назад
Good
@thesortsakis
@thesortsakis 11 лет назад
fantastic!
@marymasterman7957
@marymasterman7957 10 лет назад
thank you!
@limeroundup
@limeroundup 11 лет назад
Great explanation!
@calebhaines3794
@calebhaines3794 3 года назад
Activation energy for any and every cell in the body needs to be monitored and controlled to prevent excessive photon and quantum radiation from passing through or onto the body.
@avisekdeyati6505
@avisekdeyati6505 3 года назад
Great Talk! Different components of innate and adaptive immunity have been put together in a clear and articulate manner!
@link2442
@link2442 5 лет назад
I feel that I grasped this better and with ease than the lectures my professor gave through out the whole semester
@yorkshin8901
@yorkshin8901 10 лет назад
Nice talk
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