Awesome! Very explanatory. And you got a talent on drawing...Thank you. One question though, you know how some people age quicker than others? Could one reason be because their cells undergo more stress (chemical, radiation, and psychological stressors) which cause more cells to end up senescent?
Yes, definitely the stress is a major factor in aging. Also genetics, by that I mean that some mechanisms to cope with stress may work better or worse depending on the genes (and number thereof) that DNA carries. For example, some species have many times more genes (which are mostly just duplications) associated with DNA damage repair and thus aging very slowly: turtles. Or rarely gets cancer: sharks, elephants despite the larger number of cells in their bodies than in us humans.
The best explanation I have ever heard! 👏👏🔝💯 You could even explain this to a 5 y.o. kid and he would still understand everything! You are very talented! And the fact that you explain it through visual drawings helps even more! This video is PURE GOLD! ❤💯🙏🔝
I’m sure I’m not in your target audience ( retired,71 yr old disabled, damaged female) but I’m definitely in the top percentage of appreciative and impressed. As an obsessive student I know clear concise teaching when I see it. Thanks so much for joining clearly many of my previous random areas of knowledge.
Did anyone else gasp at 10:20 "Somatic cells can develop a mutation that allows them to be express telomerase." If that's the case, then therapy could improve our somatic cells to prevent aging. He indicates that this mutation is what causes cancer. However, if we coulid control the quantity of mutations, then essentially, all effects of aging would be reversed.
Yup. One other thing to note is that senescent cells will still appear and build up due to stress, radiation from the sun etc., and must be removed eventually. Another thing to add is that cells have a built in self destruct sequence built into their DNA. The eventual goal would be to maintain Telomere length, while ensuring that cells die when intended, in order to prevent the body from becoming it's own cancer.
You are and EXCELLENT TEACHER..I just sub'd. Thank you for being brilliant but also being able to make it simple for people that have a tough time understanding this stuff.
Great explanation, clear, concise! How exactly the shortening of telomeres cause the arrest of DNA replication, is one of the most important questions in biology. At first when I first read about telomeres, I imagined that successively smaller proteins or polypeptides featuring leucine (TTA encodes leucine) and glycine (GGG) could be produced if telomeres should be transcribed in mRNA; such hypothetical polypeptides could then have an effect (like alosteric inhibition) on DNA polymerases, when such molecules are small enough. Then I learned that telomeres are non-coding; anyone could teach me more about it, please.
Fascinating! I've been really interested in learning about the lymphatic system getting rid of these bad cells. I started rebounding exercises. There is so much to learn about the human body. Thanks for the great video!
I just wanted to say this was such an amazing helpful explanation! and thank you for sharing it! I am currently struggling with TRAP assay principles, (telomeric repeat amplification protocol), could you please come up with a video that explains TRAP principles like this one please? There are almost no videos out in the internet explaining that. Much obliged from Germany
Why would a miotic cell that develops this mutation that enables it to multiply say "infinitely" end up becoming a cancerous cell, since our embrionic cells have this already. Why would we not want this to happen to all our cells and have them be able to multiply infinitely.
Okay, but why would the somatic cell that mutated to express telemerase cause cancer if the cancer comes from damage to cells that don't have enough telomeres during cell replication. In other words you said that not having telomeres causes cell replication problems, but when that is fixed it causes more problems? I don't get that.
How does senolytics fit into this? If a cell is senescent and inactive why does the body have to kill it? Also, in eukaryotes, if a a gene is a segment of chromosome (which itself is a segment of the dna with the histone proteins it wraps around) what controls that gene function? Its shape based on the proteins attached to it? For example, if the expression of some genes (ex. sirtuin 1) can control the expression of other genes, what controls sert1?
Amazingly simple and informative video. Could you please advice how to increase telomeres ? One method is to have telomerase enzym. How do I get these? Thank you so much for what you teach others.
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+chris mcaulay I believe the information can be found with the link .ladyrp.jeunesseglobal.com/en-US/finiti/ download the PDF no obligation to order. @ the convention the Dr explained it but I'm not an MD so I hope you can get the info you need from there. If not I will inquire about getting more complete answers to your questions. Thank you.
Thanks for this... At first I thought it was nonsense but I never realised it was ta-65 - interestingly it also contains quercetin and tocopherols which had promising results in clearing senescent cells from the body. I will look into it; I had thought about a business opportunity with this as I am fairly big on anti-ageing however the product is very expensive for me at this present time, I was going to wait for isagenix to hit the UK. I may be in touch! Thanks x
My understanding: Senescence: green knight,half injured but still working Telomere:the time you have left to have kids Telomerase:god like immortality potion Cancer:someone evil stole the immortality potion Awesome
You have an very interesting way how you share yoir information. I really love your videos because they help me with my school stuff!!!really amazing thanks 😊best video
are stem cells and mutated somatic cells the only cells that can develop telomerase? and why can't heart cells/neurons become senescent? do they have telomerase?
No, it means you have cancer. At least, assuming the cell has also lost some other growth controls. If the cell was healthy and also expressed telomerase, you probably wouldn't notice much, since most of aging is not driven by replicative senescence. Cells becoming senescent for a variety of reasons is a significant part of aging, but there are a number of other factors as well. Here is a description: www.sens.org/research/introduction-to-sens-research
Brilliant explanation...what I want to know is, why at the age of 90 aren't we just one big clump of senescent cells? Do senescent cells die out to make room for new replicating cells? Aren't tissues in our bodies getting bigger and bigger as new cells are made on top of cells which have reached senescence
