This is the way to go. You’re giving a completely different approach to neuroscience to a lot of unfamiliarized students about how *actually* neurons encode and process the information in a lower level point of view. Congrats🎉👍
Great video. I've been slogging my way through Ted Jones' "The Thalamus" and this is quite a nice way of wrapping a lot of the key ideas we've developed over the past few decades together.
This video is quite a bit beyond my understanding but I had a stroke of the thalamus. You mentioned calcium channel in your video I was wondering if you happen to know if being on a calcium channel blocker medication such as amlodipine besylate is not the best medication for blood pressure in my particular case. It is a year and three months since my stroke and I still have quite a few annoying symptoms. I just wondered if you might know if another medication to treat my blood pressure might be a better idea. Thank you. You are highly intelligent to understand and explain all of this
Calcium channel blockers block specific Ca-channels in heart a vessels, which decreases BP by decreasing heart work and by it decreasing minute output and by blocking Ca-channels in vessels, which makes vasodialation, which decreases vessel resistance (BP=MO*resistance). It does not block any calcium channels inside the brain. So no, don't worry. But if you have side effect of your medication it should be discusses with you doctor. Have a nice day.
@@BuickGeek24 Yes, but those block beta adrenergic receptors and thus inhibit parasympathetic response, which decrease blood rate and by that blood pressure. It is true, that if they enter brain vessels, they can make person numb or aggravated, but that is kind of rare.
Thank you for the amazing video, so informative! The only thing I did't fully understand is about the role of t-type calcium channels during tonic potential . For what I've understood when a depolarizing stimulus has occurred , the inactivation gate of c-type channel is inactivated and closed, so that , when another stimulus arrives to the same neuron,the calcium can not enter in the t-type channel and generate the bursting potential, BUT CAN enter in other calcium channels that generate the tonic firing. Am I wrong? Thank you for you attention, and for your videos! And please excuse my poor english :)
You're almost correct! When mildly depolarised the t-type calcium channels will inactivate so cannot cause bursting. But it's actually voltage gated sodium channels which are responsible for generating the action potentials, when the membrane potential is mildly depolarised most of these are NOT inactive, so when another stimulus arrives they can open and cause tonic firing. Also your English is great :)
does neurons in the thalamic reticular nucleus actually send inhibitory signals back to first order nucleus? I though reticular nucleus can only send excitatory signals, and inhibiting is the role of neocortex.. (2:43 timing)
Absolute helplessness. No help, no understanding of how to regulate this divinely complex mechanism. Stone Age primates are trying to understand God's creation. Maybe after 10,000 years.
