Hi Doc, what an interesting explanation! Can you please provide us some links to references about this. Because this is such a new thing for me. Thank you!
I know I am late to the game with this lecture but this comes from after a discussion I had with a prof today who mainly focuses his lectures on early 1980's papers. His lecture was all about lactic acid and I asked about whether he had heard the argument between whether lactic acid exists in glycolysis or not. However I could not find a lot of papers backing up what I had heard in a previous uni course in metabolism where my previous prof had stated the same hypothesis as Dr Mike (it is not present and we should stop referring it as lactic acid). Would be great if I could have some links to papers or authors on this topic.
Here is a reference, that was used in his explanation for why lactate doesn't exist in less than 2 minutes. journals.physiology.org/doi/pdf/10.1152/physiol.00033.2017
@@dirkjordaan9044 yes my comment was asking if I can have references or links to different papers. I understand lactate acid is outdated but would love more papers on it
I have been telling students about the misnaming of lactic acid for years. My physiology teacher explained this to my class back in 1999. Many times when I would mention this people would laugh at me, even my fellow teaching colleagues. In the following years a lecturer of New Mexico university also spoke about lactic acid misinformation during seminars for the Filex Fitness Convention. It amazes me that 25 years after I was first taught this, many people still believe the incorrect explanation.
Thank you for such an informative video of course you’re just one source may I ask where you got your information? and could you post the following links for further review of this new theory. Thank you doctor
Reminds me of athlene x. I look it up to find everything I know was wrong! Do you think there is some benefit of eating not necessarily vegetarian diet, but a base pH food diet? If you eat a lot of acidic food when your body be acidic? I wondered if that would contribute to a longer muscle recovery period.
There would be an equilibrium of lactate and lactic acid depending on pH. A conjugate base (lactate) and a hydrogen ion would form a weaker ionic bond, not a covalent bond, so it's a reversible equilibrium. If you extrapolate his theory here, then once the pH gets too low (concentration of H+ gets too high), the fatigue of your muscles is going to paralyze or slow you down since you don't have enough lactate or other buffering molecules to keep up, and that will give your body time to produce more and finally get you moving again.
hey doc i wanna read up on the journal that you are referencing from, could you leave a link to that? and plus, then how do we prevent muscle soar ? any good ideas? great explanantation anyways! it makes more sense that lactate is produced under both anerobic/aerobic conditions. just seems more natrual.
Hi Doctor Mike. I have 2 questions. 1. Does the food you eat have an impact on this cycle and, if so, what foods should an athlete eat & when prior to running? I find runners can assist their body with maintaining oxygen levels by upright posture & breathing in through the nose (nitric oxide released) and out of the mouth & having economy of movement. Stop drinking (sipping) water at least 1 hour before a race helps too as it prevents the liver acting up. Looking ahead keeps the body calm yet focussed (parasympathetic nervous system activated). I have tested these methods on athletes who run uphill. Do you know of any studies which discuss this?
awesome, so what do you think about beta alanine? i am a competition freediver and after 3 minutes of diving holding my breath my legs simply stop working, thinking it was lactic acid or lactate; would beta alanine help in your opinion?
What about the end product of the ECT. Doesn't it produce an h+ and oxygen binds with it to make a water molecule and if there is no oxygen present then the H+ will slowly get into the blood?
Will this be altered in someone who in high levels of ketosis? Not to encourage people to do the ketogenic diet because it’s a serious treatment with risks and benefits like any therapy or medication if the benefits outweigh the risks then it’s worth trying under medical supervision. I am on classic ketogenic diet 4-1 ratio for replacement of anticonvulsants that had worse risks for me in particular and I take a different anticonvulsant that was not quite effective enough for control of my condition it helps with that in conjunction with medication but I wouldn’t recommend it it’s better than the alternative for me but that’s only because my alternative treatment had more serious side effects than ketosis at this high level. I find that I get a lot of muscle pain and fatigue and the cold seems to help me recover from the soreness quicker so I can still walk the next day. I always walk around if I have muscle soreness because I was told that helps get the lactic acid out of the muscle and drink extra water to flush it out and eat more protein to encourage muscle repair I also find hot baths help later in the day but immediately after a workout they seem to actually make it worse. The cold does seem to help reduce the soreness for quite a while and help me recover quicker. But without my body running primarily on glucose will what your explaining be altered or will the body just break down muscle further to create glucose?
Ya out here in the real world your patient with liver failure will develop lactic acidosis - a high anion gap metabolic acidosis. You can't just act like lactate is good for them, or that the extra hydrogen on what used to be pyruvate is harmless. You must intervene to prevent an arrhythmia by raising the ph of the pt by whatever means makes most sense clinically. Then, you continue to respect the lactate by consistently checking the pts changing acid base chemistry. What makes your muscles sore is the process of anaerobic glycolysis. The cell will become acidic - primarily buffer out - but continued use under an increasingly acidic environment will cause cell damage and an inflammatory response. Your nerves activate/perceives pain via the presence of cytokines (IL-1 from TNF-a) and other subsequent immune responses. Your nerves are literally sending signals as the cytokine receptors on their cell surface encounters a concentration of cytokines sufficient to create adequate calcium concentration in the dendritic bulb. The issue I have with taking advise from youtube doctors is that most have about a 20% understanding of how the body works as a system, and without full mastery of the topic they just produce blaze half truth content. This topic is harmless, you are right but in part by chance, and having the general public use lactic acid as a way of conceptualizing how to avoid injuries and how to recover is ultimately much more helpful than harmful. But, hey these PTs do look a hell of a lot better than me with their shirt off. Source - look up any book or chapter on nocioception. I don't even practice this type of medicine and after 10 years I was able to quickly explain the above - remember you are who you listen to.
So. Question. Would you say eating too much sugar causes more of a lactic acid burn and long recovery when your train and lift weights? If thay lactic acid burn is staying even after training, what is this a sign of? Nutrition wise. Thanks for your response
@@yassina-r6806internal friction if muscle cells.... Bruce Lee did isometric training to eliminate d.o.m.es.....try drinking 12 oz water with a little 1/4 teaspoon baking soda.... Lower rep's little heavier...
This is exactly what he is talking about - outdated information. Look up the studies yourself, there are many since 2015. Correlation versus causation. Just because lactate is high, does not mean lactate is causing the issue. As he mentioned, lactate may be high as a result of your body trying to use lactate to combat those issues.
Video is amazing and very useful but I can't understand ur running English properly...! But anyway I understand a little bit and it was useful for me......! Love from INDIA 🇮🇳🇮🇳
So what's going to happen immediately within a few minutes of no oxygen and just anaerobic respiration? Because so far you can read online about lactate or lactic acid poisoning the body?
I had a question though after lactate came to mitochondria and became pyruvate again how would that become acetyl coA (and go to cycle) again? Since as far as I know PDH activity declines rapidly after the tense exercise, so it is confusing for me how we tend to decrease lactate during the recovery and how we have so much acetyl coA during recovery while PDH is not active…
So what causes my debilitating burn/ fatigue under light load but not heavy load? I can run miles and miles. Entered multiple marathons. But a simple 10 step flight of stairs my quads burn and fatigue half way through that I struggle to make it to the top. At the gym I can curl 60lbs dumbells but struggle doing a set of 10 with 15lbs because of the burn and fatigue. It clears up within 10 seconds of stopping. Working out and staying active has been a part of my whole life. These symptoms have been present only within the past few years.
i saw some people use to measure their lactates during training, like runners. Why would that be important for training preforamnce ? should they maybe measure H+ ?
I have a condition where my lactate levels go up 700% of normal high level during level 3 cpet w r heart cath test at ucla a few weeks ago , what is making my muscles burn and what is causing the lactic acidosis"" or whatever its called if it doesnt exist, the bottom line im asking how do i nake my muscles function better and be balanced, the lactate is way off in my body all the time, any answers appreciated
George Brooks is the most cited researcher in this field. Here is a nice summary from Cell Metabolism www.cell.com/cell-metabolism/comments/S1550-4131(18)30186-4
@@michaelscarlett8977 Last month i had an infection and my Serum LDH level was about 1496 Which is a high number and i was feeling Burning sensation in my body but i felt good After treatment Now i still feel burning sensation in my body whats that cure even my All tests are In normal range like Liver and Thyroid etc
Trying to figure out if H+ ions is the culprit for acidosis/muscle fatigue, how is molecular H2 supplements claimed to increase energy and reduce oxidative stress?
I hate to be that guy, and I know I'm late to the game, but do you happen to have a source for the outnumbering of lactate to pyruvate? I'd love to cite it in a paper I'm doing on lactate and muscular acidosis for biochemistry.
I just wish I could walk more than three minutes without my muscles fatiguing. It is taking me 20 minutes to walk from my building parking lot. Is there hope? What can I do? Do I have Possibly have MS?
If the acid being created is the potential cause for muscle fatigue and pain, could you potentially prevent this from happening by taking an easily absorbable form of calcium prior to exercise?
The main difference between aerobic and anaerobic respiration is the latter has no oxygen to accept the hydrogen ion. As a result, this task is left to the buffering system. When that system gets overloaded and blood pH begins to drop, is when it hits the fan and performance drops.
But oxygen is always present. It's the energy demand (intensity) that determines the rate of lactate production and anaerobic contribution to the workload.
Hello I need some advise, I exercise almost every day have a training and I do BMX racing, after few rides I have ,,hard,, legs, I just feel like they are made from stone - it causes a problem with my technique. So probably a lots of lactic acid, but what should I do🤔? Should I do any kind of exercice in the gym? I do plyometric, heavy lifts, stretch a lot…dont know whats wrong. Can anybody pls give me an advise?🙏
Then why do textbooks contain the wrong information ? why has this lactic acid issue became so stubborn ? because really every textbook I have read, still has a line blaming lactic acid as source of muscle soreness and further says that methods like hot bath help because they reduce lactic acid concentration. Why have not textbooks corrected it in decades from the time this fact was discarded ?
I was taught that without cofactors like B1 and Magnesium, Pyruvate gets shunted to Lactate via LDH enzyme. One of the symptoms of deficiencies in either of these is calf soreness. Supplementing alleviates this by pulling Pyruvate back to TCA cycle thus reducing Lactate.
If its not lactic acid that makes muscle fatigue, is it because we lack glucose or we lack pyruvate, or need to optimize or add more mitochondria but how to increase mitochondria?
Bodybuilding increases muscle mass which in turn creates more mitochondria in the new cells of said new mass. Technically it's called fatigue training, it's designed to give you more stamina but humans are dumb af and made it into a stupid vanity competition.
After workout I feel horrible , even if I walk for long periods . I get breathing issues and it effects my potassium levels ( low potassium ) the ph in my body changes for the worse . Some foods and drinks trigger it too . I don’t know what to do
I had a horrible allergic reaction. Kettle chips Parmesan garlic flavor has lactic and acetic acid in these chips! My legs were in pain and I couldn't feel my feet. migraine, chills and throwing up.
Lactic acid "probably doesn't exist"??? And what happens if someone is on keto and theres no glucose? Now we don't have pirivate or lactate? Let me tell you I have LOTS of energy in the gym. My concern is I also fast twice a week and so I'm a little bit worried that I'm not recovering enough. But there's no way to know.
I was watching a video about how when we have alot of lactic acid the closer we get to our threshold the more it contributes to nausea when running or lifting weights. Is this true and after hearing what youve said about how perhaps we produce this lactate to combat fatigue my question is where does my nausea come from?
I doubt your nausea has anything to do with this topic at all actually. Usually nausea during training is caused by a redirection of blood from the gut to the muscle you’re working. Take for example you eat a pre workout snack, or anything in general and you begin working out, your body requires blood being sent to the gut to continue digesting any nutrients left but since you’re working out , blood is being redirected to your working muscle causing nausea
So glucose-high snacks help to increase glucose levels in the body to then turn into lactate to reduce muscle fatigue, so should people working out eat snacks with lots of glucose in before/during workouts? Edit: btw I'm not saying anything sugary, but stuff that's high in glucose, since there are many types of sugars
I get panic attacks at literally the most random times, after workouts. I was told my brain had more lactic acid, anyways, that’s my take because I have no idea what he said.
