It's NOT "to prepare for hypoxia"-you've mentioned it at least twice, and making unverified claims is not acceptable. The person whose effect you were referencing believed otherwise! Warburg grew increasingly convinced that the phenomenon he had discovered the cancer cell's reliance on fermentation was the key to understanding the disease. "From the standpoint of the physics and chemistry of life," Warburg said, the "difference between normal and cancer cells is so great that one can scarcely picture a greater difference." Warburg eventually came up with an explanation for the phenomenon. Burning food with oxygen is a much more efficient way to generate energy. If cancer cells were running their backup generators even when there was plenty of oxygen for the power stations, it could only be because those power stations were somehow damaged.
How can we take advantage of the Anaerobic Glycolysis to attack the cancer cell as a DIY treatment? The medical/pharmaceutical system doesn’t seem to be working on that as it might be an off label out of patent drug that could help and save thousands/millions of lives.
@@egg399. Hey, I don’t think there is a “DIY treatment“ for this. However, there are currently several approaches being investigated for this. I am actually currently working with something that is also being investigated as a method to increase oxygen delivery to tumours as a potential future cancer treatment. I am happy to share some reviews with you if you are interested in an overview of how some scientists are trying to use the Warburg effect to target cancer cells.
@@Annatomyy I’m all ears! Would HBOT cause more ROS in a cancer cell? If a TKI is used then would HBOT work against it or will it help with the treatment as an adjunct? How would O2 get into the cancer cell if it’s yet to receive a blood supply from VEGF expression?
@@Annatomyy P.S. There are most probably millions of people who won’t have the time to wait for future treatments as the wheels of the FDA etc are slow. 5-10 years I think to approve a drug/treatment. It’s a shame low/no toxicity treatments can’t be used as i’m sure a large % of patients die from the effects of the SOC rather than the cancer. However if nothing is done the cancer will kill them without a doubt.
@@egg399. I do not know the details of this, but according to a quick google search it seems like HBOT does increase ROS. Similarly I do not know a lot about the interactions between TKI and HBOT, but this is something a doctor who specialised in this area would have an idea about. Cancer cells do already have a blood supply, and therefore already receive O2, VEGF stimulates the growth of blood vessels and therefore only increase the blood supply to the tumour.
Excellent short summary. Could you now comment on the energetics and reaction rates (kinetics) of anaerobic respiration vs aerobic glycolysis. It's obvious (?) that normal oxphos must be a slow process compared to aerobic glycolysis; do we know what the overall rate of reactions are and the amount of free energy produced and the mole of glucose consumed by each process per unit time?
