Delve into the complexities of the human brain with an exploration of single-cell epigenomics across various brain regions. In this webinar, Dr. Wei Tian of the Salk Institute will shed light on how DNA methylation and chromatin conformation at the single-cell level underpin gene regulation in the human brain, offering unprecedented insights into cellular diversity and regulatory mechanisms in health and disease that could revolutionize neurological research and therapies.
What will you learn?
-Cellular Diversity in the Human Brain: See how a comprehensive epigenomic examination at single-cell resolution of over half a million cells from various brain regions led to the identification of 188 distinct cell types, enhancing our understanding of the brain’s complexity.
-3D Genome Organization and Gene Regulation: Learn about the intricate relationship between DNA methylation, chromatin architecture, and gene expression across the brain’s diverse cell types and regions, highlighting the specificity of gene-regulatory mechanisms.
-Innovations in Cell Type Identification: Explore the development of single-cell methylation barcodes, a novel tool that uses the methylation status of specific genomic sites to accurately predict brain cell types
14 мар 2024
