"Arima-HiC: A simple and robust Hi-C workflow for signal-enriched and high-quality chromatin conformation and genome assembly analyses
Within living cells, the genome is folded into complex three-dimensional (3D) structures whereby DNA segments that are spatially proximal in 3D space can be far apart along the linear genome. Hi-C is a proximity ligation sample preparation method that captures spatially proximal DNA interactions within cells. In doing so, Hi-C uniquely leverages intrinsic genome folding properties to simultaneously capture chromatin looping structures that regulate gene expression, while also preserving long-range sequence information that can be utilized to scaffold contigs into more accurate and comprehensive chromosome-scale genome assemblies.
In this webinar, Dr. Anthony Schmitt, Vice President of R&D at Arima Genomics, will describe the Arima-HiC technology platform and how its use can accelerate the path to biological insight in epigenetics and genome assembly applications. The presentation will:
- Overview Hi-C technology, including how it can be used to uncover genome organization structures for epigenetic studies as well as scaffold contigs into chromosome-spanning genome assemblies
- Overview the Arima-HiC workflow, from Arima-HiC sample preparation to library preparation and Illumina sequencing
- Overview Arima-HiC data analysis for chromatin conformation and genome assembly using powerful and user-friendly open-source software tools
- Present Arima-HiC usability and performance data, including accuracy of chromatin loop and topological domain detection as well as accuracy and contiguity of chromosome-spanning assemblies
If you would like to know more about how Arima-HiC could help you, contact sales@arimagenomics.com for more information.
arimagenomics.com/
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27 май 2024
