Tracking and Measuring Biomarkers to Maximize Longevity with Dr. Michael Lustgarten

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In this week's Everything Epigenetics episode, I speak with Michael Lustgarten on tracking and measuring biomarkers to maximize longevity. His long-standing goal is to live longer than everyone that has ever lived. To do that, he plans on using the best available science to “biohack” his way to super-longevity. Contrary to the prevailing belief that aging is an inescapable and uncontrollable process, Michael is an advocate for longevity, and he's eager to impart valuable tools and insights that could potentially extend our lifespan beyond 120 years.
During this episode, you'll gain insight into various aspects, such as what inspired Michael to adopt a personalized health approach, his definition of optimal health, the vital role that data plays in improving your overall health, the specific blood panels Michael recommends, and the benefits of tracking diverse health data. We also discuss his epigenetic age results in depth, as he has measured this process around 10 times, and strategies for optimizing nutrition, exercise, sleep, and biological aging.
Michael Lustgarten is currently a scientist at the Tufts University Human Nutrition Research Center on Aging in Boston, Massachusetts. His research currently focuses on the role of the gut microbiome and serum metabolome on muscle mass and function in older adults. In his large social media presence, Michael shares his experience with his rigorous n of 1 experiment over the last eight years and shows how anyone can conduct a similar trial by tracking food, exercise, sleep, and epigenetic age measure results and derive relationships between them, with a goal of extending our healthspan.
In this episode of Everything Epigenetics, you’ll learn about:
- Michael’s “biohacking” background and academic background (English degree and PhD from the University of Texas Health Science Center at San Antonio)
- The story behind Conquer Aging or Die Trying
- The definition of aging
- Aging as a disease
- The importance of the microbiome
- How we can slow down the aging process
- The importance of tracking biomarkers
- What biomarkers Michael is tracking and WHY
- The effects of hormones on epigenetic aging
- The sex paradox (men age quicker than women)
- How to optimize your diet through self-tracking
- The difficulty and complications of measuring biomarkers
- Michael’s epigenetic aging results (Horvath clock, Hannum clock, DunedinPACE, and Telomere Length)
- The effect of caloric restriction on the DunedinPACE
- How to optimize your fitness levels through self-tracking
- The effect of physical fitness on epigenetic clocks
- How to optimize your sleep through self-tracking
- What Michael is NOT tracking
- Michael’s most surprising find from tracking biomarkers over eight years
- The future of Michael’s career
Where to find Michael:
RU-vid Channel: / @conqueragingordietryi...
Twitter: / mike_lustgarten
Dr. Michael Lustgarten is Scientist II on the Nutrition, Exercise Physiology, and Sarcopenia (NEPS) Team at the HNRCA. His research currently focuses on the role of the gut microbiome and serum metabolome on muscle mass and function in older adults. Dr. Lustgarten has been a guest lecturer at the Friedman School of Nutrition Science and Policy on topics such as the gut microbiome, serum metabolome, oxidative stress, exercise, and sarcopenia. He has contributed to 31 publications in leading peer-reviewed journals that have been cited more than 3,700 times, including 17 manuscripts as the first or last author.

Опубликовано:

13 ноя 2023

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Комментарии : 18

@peterz53 8 месяцев назад

Thanks! Been following Michael for years. Tracking markers and making changes is key even if some of the markers are not as precise as we'd like. Would be great if we had a hierarchy of biomarkers. Might be that by identifying certain nodes or upstream markers to optimize we take care of most things downstream. As it is now a lot of markers are put on a roughly equal footing by default. Also would be good to identify the primary markers for each organ system. But even in this case, it might be that by focusing on optimizing for the brain or the cardiovascular system, and few other organs like liver and kidney, we take care of most things and create a system within most peoples capability to implement.

@everythingepigenetics 8 месяцев назад

You're welcome, Peter! I hope you enjoyed it. I agree on all fronts. It can be very confusing at first, however, we have to start somewhere. I think we will what biomarkers to prioritize once we learn more... my company, TruDiagnostic, is now looking at clinical lab values, proteins, and metabolites that affect your aging the most!

@jonathonmills3563 5 месяцев назад

There was a recent Horvath presentation on Life Extension symposium I believe where he talked about a complete Mammalian genome for methylation, and that 30% of species over express maximum life genes in women. Humans are one of those mammals

@everythingepigenetics 5 месяцев назад

Thanks for the insight! I will have to take a look.

@Dr_Oleg_Kulikov 4 месяца назад

The only reliable and easy-to-measure mark of aging is the stiffness of your arteries. Surrogate measures of it are Pulse Pressure which is a difference between Systolic and Diastolic blood pressures, and resting heart beat rate. The epigenetic clocks based on methylation or telomere shortening are absolutely overhyped, expensive, and not reliable tools. Micro-biome is very important, it is true.

@everythingepigenetics 4 месяца назад

I'd love to see the hazard and odds ratio to disease for the stiffness of your arteries and learn more! Do you have this information or any reference you can provide?

@Dr_Oleg_Kulikov 4 месяца назад

@@everythingepigenetics sure. drive.google.com/file/d/1kfgA23C3cxlWwvoFiMwjM-TPcGqRqkI6/view?usp=drivesdk There are links inside too.

@geladaizlabon3605 3 месяца назад

Interview Bryan Johnson next 😅

@everythingepigenetics 3 месяца назад

This may be coming soon... :)

@EkilRevolution 2 месяца назад

About the discussion of women liveing longer than men, I think the "how" is multi-factorial and too complex to explain well. But I have an idea about the "why", and it extends to most mammals not just humans: Males are able to produce more offspring in their lifetime, whilst females are limited by the burden of sheer time, as well as resources, required for pregnancy. A mechanism to prevent a particular organism (carrier of genetic information), fecundity evolves to be more limited as longevity increases. This evolutionary (not necessarily physical) trade-off improves adaptability of a groups of organisms. I may not be explaining this clearly, but group selection is real and the Selfish Gene theory is only a partial truth. The same concepts of adaptability and group selection gave rise to ageing. Ageing is not an evolutionary dysfunction, and neglect does not fully explain the existence of ageing. Ageing is beneficial (obviously not at an organismal level). Josh Mitteldorf deserves credit for helping me realize this. This is why caloric restriction can delay ageing across most species. Delaying the program of ageing can prevent extinction during famine when successful reproduction is limited. Ageing faster when overeating is beneficial to prevent rampant population growth. So basically I suspect males age faster because they have greater potential to spread their genetic information, and a shorter lifespan can off-set this imbalance. Makes me wonder if abstaining could slow male ageing (after controlling for the beneficial aspect of emotional reward). About the how females age faster, anything that happened to give rise to slower ageing compared to males would serve the same function. It's possible that male hormones are more pro-ageing, or that increased growth is pro ageing. It's possible that the identical sex chromosomes (XX) of the female confer a DNA repair advantage.

@EkilRevolution 2 месяца назад

this imbalance of potential reproductive success of males vs females explains the paradox where females begin puberty earlier yet don't live shorter. The later puberty in males limits the time period of potential reproduction. Evolution creates balanced organisms not superorganisms.

@KoiRun50 6 месяцев назад

In general men have thicker bloods than women. They tend to run higher in hgb, hct and rbcs. I think is one key reason why women live longer than men.

@everythingepigenetics 6 месяцев назад

Thanks for the insight! Interesting hypothesis

@Mikolas649 6 месяцев назад

Without any take aways, it's hard to listen too, give us something...

@everythingepigenetics 6 месяцев назад

Thanks for the feedback!

@AyubKhan-el9kk 5 месяцев назад

Women live longer than men because their red blood cell population is renewed each month due to mensuration. Holding other variables constant this biological difference would result in optimisation of blood biomarkers (Hct, Hmg, RDW etc) and down stream benefits of younger RBC population on other organs and tissue.

@everythingepigenetics 5 месяцев назад

Thanks for the insight! I'd love to see the research around this. Do you have that you can share with me? I think it may be a great hypothesis, however, we know that according to TruDiagnostic's new OMICmAge (the most predictive biological age clock created to-date), we want to increase Hct and Hmg and decrease RDW to optimize aging. This has also been validated in previous literature as well!