The games and series are loosely connected in what is called the "Aligned" continuity family. Besides, the Nemesis in "Prime" was a awakened by Dark Energon, whose effects are... tricky at best.
they went back to basics with DESIGN, making it similar to g1, but the actual storyline of the games is connected to the prime series, as they have been officially stated to take place in the same universe, whereas g1 is a completely separate universe.
The Cybertron games are in no way contacted to any other comic/movie/television show. It is its own thing. The developers have said they try to keep most in common with the original G1.
Hasbro says otherwise in lore fall of Cybertron is both apart of and not apart of the aligned continuity Simply put: one universe (aligned continuity including WFC and FOC) and another universe (just WFC and FOC)