TWiV 677: Does antibody really know what time it is? 

Yes, it is 4:30 AM Dia de los Muertos, Day of the Dead, and I am dedicating my altar to all those who have died from Covid-19. Be safe everyone and wear your masks.

Hey, guys, I just wanted to thank you for what you are doing. These podcasts have been my saving grace this year. My background is in neuroscience, so I have been listening to Vincent’s Virology 101 class to get my feet wet, then coming to you all each week to learn the current state of virological research and to get the clinical picture from Daniel. I just read the comments section here. I feel the need to apologize for many of them, personally, (I have decidedly low self esteem), because even some highly educated Americans tend to display a masochistic inability to learn and grow, and find it necessary to exercise their own inadequacies through a “brutal takedown” 🤣😂🤣🤦‍♀️ of those who simply aim to share their own knowledge publicly. This, of course, is a historical, yet current, correspondingly political, characteristic. I love you guys. Keep doing what you’re doing, if only to maintain my personal sanity through the next several months. 💖

Dr. Vincent, I'm praying you had an asymptotic infection and will experience strong immunity in the future. I don't always agree with your assessments but I believe you are a sincere human being. Actually, you are probably kind and gentle too.

Thank you TwiV for keeping us informed... This is how I get my covid information from and I look forward to Sunday to hear Daniel.

I've encountered my first anecdote of reinfection today! A deli guy in Queens, NYC and his GF got COVID in March. He spent 3 weeks in hospital, she spent 2 weeks. Both got oxygen treatment. His GF got reinfected in September and went to the hospital for 1 month. He did not get sick. I told him it could be because since his March illness was much longer, he might have made more anti-bodies so it takes longer to drop. His did seem like a very bad case. He used to run, but he still cannot run after so long. His doctor told him in the beginning that the stuff in his lungs on the X-ray may be life-long. That's pretty sad. Hope his anti-bodies last that long too, but probably not from the data. :(

Good to see Brianne being consulted multiple times when there any link to the immune system. Keep up the good work.

Midweat( near StL): 1)COVID tests here avg wait is 3 days. 2)Schools: mask up. No masks on weekends and nice days in neighborhood. 3) many have # people going to Thanksgiving homes. ( no info to mask wearing: idea that 2 separate units are isolating, then gathering together.)( appears to be OK to do this) 4)what about taking Covid tests: on anyone drawing labs for anything. Could, would we get a wider idea about infection? 5) Trick or treat at our home was a bucket pulley system. Many parents loved it!! 6) many were walking w masks up and in place. 7)Thank you fod all the comments. And to Dr Griffin!!

I watch/listen to these while I'm working but when I have to concentrate on something I do have to pause it so I can concentrate.

SARS2 incidence correlates with high incidence at high temperatures and high incidence at low temperatures. The lurking variable is being indoors where climate control is used.

Get well soon Vincent!

I have a lot of trouble swallowing the 6 foot & 15 minute "rule". I certainly wouldn't rely on it!

Lab folks please be careful!!! We need you.

Do we know the break down of the current positive test results? Such as what % are false positives....what % are mild disease...what % are hospitalized ...what % are asymptomatic?..Everyone is talking about increase infections but no one is breaking this down. Do you have these numbers or can you point me in the right direction....Thank you!! Love your show!!

Freedom without responsibility is an empty cry

Daniel you are a star. Thank you

Thank you, from Melbourne, for the semi-Melbourne themed episode! (lol Vincent's pronounciation is perfect). Stage 4 restrictions have been gradually lifted over the last week or so (we're allowed to have one person over to your house, once a day now) - and retail/hospitality just opened back up the other day. I think the last three days now we've had zero new cases or deaths (in Victoria). I'm 30 and myself and most of my friends live in sharehouses... one of the weirder things about the lockdown was that - to reduce moving back and forth between houses - so many of us who have partners (usually living in other sharehouses) had to work out which house to basically hermetically seal ourselves in lol. There was a condition of the restrictions that you could travel further than 5km to see your "intimate partner" (but not outside the curfew)... but most people I know just cocooned themselves in.

prophylaxy for everybody at risk (older than 60) with vitamins, zinc, quercetin, anti-oxydants, fresh air, walking, balanced food , minimum 6 hours sleep. this should be government guideline , but it is not : i wonder why ? what di they want ? what role the health institution are playing ? are they interested in the general public having low defenses ???

Daniels quote was from the Bible book of Ecclesiastes 3:1; "There is an appointed time for everything, A time for every activity under the heavens". Nice quote

Why no discussion of vitamin d?

Can agglutiation occur in covid19 at the beginining at second faze, induced by high level of immunoglobulins? by decrease of blood temperature and by aglutinogen of group A2,B3, orAB4 of the surface of Red cells?

I do some repetitive work that doesn't take a ton of attention, and that's when I love to listen to TWiV, I also listen to you when I'm falling asleep.

I like Daniel, but normally he has bad news... Today he actually made me hopeful.

Vincent said he likes numbers with $$ signs, if each of us gave just an average of a buck or two per session we watch it would go a ways, I gave through "Parasites without Borders" for double the effect thru November.

"Does antibdy really know what time it is?"."Does antibdy really care?"

Who wouldn't just love their GP to be like Daniel?

Thanks from Ontario, Canada. I look forward to your podcasts. I've learned so much. I agree with Dixon that Brianne has a beautiful smile and have thought so for a long time. Do let her speak uninterrupted from time to time.

Very exiting news from Daniel - Thank you. Does anybody have references for monoclonals in the early phase and for Toci as an addon to steroids?

2:31:13 The "Promethius tree" that was cut down in 1964 on Wheeler Peak in NV (not AZ and not in the White Mts, it's clear across on the other side of NV in the Snake Range) WAS/ remains the oldest documented living tree, at least if you don't count its untimely death by chopping. There is a non-documented account of another Great Basin Bristlecone Pine that may be slightly older but the person who found it died and its location is no longer known, and the bored core proving its age cannot be found. The current oldest known tree is another Great Basin Bristlecone Pine known as Methuselah in a secret location in the White Mountains of CA/NV (just east of the Sierra Nevadas). The tree is in CA. It may now be slightly older than the Promethius tree was when it was cut down, but was 'born' (germinated) after that murdered tree, so if Promethius hadn't been chopped down it would be older... Promethius was at least 4,862 years old and possibly more than 5,000 when it was chopped down by a scientist trying to figure out its age - probably the biggest mistake ever made by a botanist. en.wikipedia.org/wiki/Prometheus_(tree)

One more question - what percentage of the high risk population ended up in the hospital at the height of this? Why push drugs - why not push Vit D - it has been proven that most who get really sick has ended up in the hospital.

Health Care Professionals are awesome! We respect you and love you! 👍👍💪💪

My B cells are like Dory in Finding Nemo!

I need a cleanup on IL6 (aisle 6) lol. How do monoclonals work on the chronically infected, reinfected, and relapsing long haulers with post-inflammatory syndrome?

Very informative! Thank you so much. There was a pastor from New York (I think) where they did a subgroup analysis for corticosteroid use in the inflammatory phase. RECOVER is rather unspecified in the inclusion criteria (Sars cov 2 and oxygen supplementation). The paper retrospectively analyzed for CRP as a surrogate parameter for inflammation. Turns out people with low crp don't benefit (as I thought) Could you elaborate and talk about your experience?

Question .. Why is a drug with known side effect of liver damage OK to give to asymptomatic person but not given to one who is very sick?

I always wear my mask when out of the house and sanitize or wash my hands, but it never fails that someone sneezes near me. They're wearing a mask, but they don't bother to put their face in the bend of their elbow to help keep more ick mist from blowing out into the air. grrrrrrrrrrrrrr

Even with false positives, people should STILL take the necessary precautions.

thank you both...excellent teahing, thank you

On false positives... is it possible for mucus to have trapped enough virus for a PCR to amplify. i.e. the physical natural protection of the nose could have caught enough fir a test to notice. A runny nose from allergies might be helpful if mucus is expelled and not aspirated. Simply following the previous test subject that was infectious noticed the Inoculum.

VERY HELPFUL..PREDICTABLE ..thanks

Many happy returns to Mrs Griffin, and best wishes to all the ‘other halves’ who keep their beloved scientists and staff safe, well fed and happy. I heard someone say, a hospital bed without staff is just furniture. So true!

I’ve been watching you for the past few months and you have quickly become one of my top sources of COVID related information. Here in Western Canada, we have done somewhat well, though in the last couple of months things have taken a downward turn. Masks are mandated in many cities within my province, but for reasons I don’t fully understand, the government seem to like to wait until the numbers are high enough to warrant it (nothing like learning from the experience of others... but I digress). Businesses are open here, including restaurants, though at limited capacity, and masks can only be removed at the table. Hand sanitizer is available at the door of most businesses and employees politely remind patrons to use it if they don’t notice it or forget. Schools are open, though those who choose to home school are given that option. Masks are mandated for children above grade 4 (ish), but can be removed when seated in the classroom. This last bit concerns me greatly, given the fact that we now know this can be airborne and that children are so often asymptomatic, and seem to be the perfect little vectors. Friday we had over 600 positive cases in a population of 3.5 million, but we are testing 12 to 18 thousand people a day, and have a fairly robust contact tracing program. Still, roughly half of our cases are of unknown origin, and of those that are traced back, many are attributable to private gatherings, parties, funerals and the like. The government in our province seems adamant that no further lockdowns should take place, and are reluctant to close schools. Last week the government mandated a restriction of 15 people for private gatherings. I worry that perhaps many of our cases are originating in the schools... Johnny has no symptoms, gives it to mom and she may or may not get symptoms, but then she goes to visit grandma... you get the picture. Thoughts?

Hi, thanks so much to you all for educating us. I would like to ask Brianne why she likes certain masks and dislike others. Also, is it possible to get a certification from any of your courses online?

Are these courier delivered Monoclonals delivered to every state or just NY?

Great talk thanks a lot for this

If SARS COV2 better replicate at low tissue temperature (that say Christian Drosten at TWiV Nr 659 at min29). may be contamination did not always induce mucoseal infection .If temperature increase)(?) If after contamination. infection. did not occur always. may be PCR test negativate rapidly?

2:16:38 ... Melbourne pronounced to rhyme with born is in Derbyshire, England. Melbun (sic) and presumably the one in Florida are named after the Derbyshire village. And a lovely place it is too.

for real is my sunday morning ritual

Somebody who is not as lazy as I am, please get me the info of that book about dandochronology, thank you.

Stop thinking about viruses and relax by thinking about other things, are you serious? I’m relaxing by listening to podcasts about viruses to take my mind off the election!

Excellent discussion and very informative. Pity that you are not allowed to have some of your peers from China on the panel, given China's ability to completely control the pandemic vs America's complete inability to control the pandemic. None the less, thank you for the great podcast and looking forward to the next one.

Daniel do you not think that this an extraordinary time in history to gather scientific data which would not normally be available under normal conditions. I think we will see the lockdowns, with all of the collateral damage, as a blessing in disguise. It has provided us with unlimited research opportunities. One problem I envisage is that the susceptibles are rapidly disappearing, for instance here in South Africa, and the time to do the research may be a limited window of opportunity.

UMD is testing staff and students every so often but it's a large number, probably the whole population.

It's Sunday! 😃 TWIV! 🤓 Yoga! 🧘 Laundry... 😝

Ivermectin is cheaper than opening windows, and it actually works.

Ebola can persist in sanctuary sites.

Its wrong now, and TWIV us wrong too. Ivermectin? You better debunk that one, or you will look way off. And leronlimab is superior because it halts RANTES, the QB of SARS2 hyperimmunity. So this discussion does not comprehend the breadth on monoclonal coverage. In aggregate your immunology is way off.

Time for .... is from the old testament. Or Torah. Which book? Ill havr to look it up.

How is a false positive possible in a PCR? Does the machine create coronavirus RNA out of nowhere or what?

Which is worse Remdisivr or Hydrochlorinique? Remdisivr is inferior, and patients with no insurance are rung up for $118,000.

It’s my birthday!!!!

I couldn't make sense of what Daniel Griffin was saying when he spoke about his friend Peter Dates. Daniel said - A Friend of Peter Dates (Friend 1) went camping in the Dakotas with another friend (Friend 2). Both got Covid-19. My questions are as follows :- 1. Which of these friends died, was it Friend 1 or Friend 2 2. Which of the two friends was given Hydroxychloroquine and Azithromycin, was it Friend 1 or Friend 2 I don't suppose Daniel Griffin might know at what viral stage the Hydroxychloroquine Azithromycin was prescribed, and if the patient was advised to use Zinc supplementation.

"Even if under and an administration change..." - looking increasingly likely that this will NOT happen.

Lovely ... Random testing like a drug test. Getting people used to being probed.

I was just listening along and then I heard "deliberately racist" when used against the nation of China. I think that is a mischaracterization of what has happened. It is impossible to boycott most Asian or Sub-Saharan African country without being 'deliberately racist' due to the population dynamics of countries in the Congo, Nigeria or Viet Nam or China or Japan. It is simplistic and implies 'wrongful nature of thought.' which is really hard to rationally shoe-horn the language of discrimination to monolithic population dynamics present in other countries. Was America 'anti-German' in WWII ? Hard to be racist against Germans when they constituted around 30% of the US population. We also are uninterested in Russian vaccines - what ethnic group or race or we being deliberately racist towards there ?

Dexamethazone has been front line in India for a long time and is not risk free.

Oh that sucks

love it

You are very late with a sketchy description if phases also.

Every phase has an unapproved treatment and they aren't from Gilead or Reverend. In NYC Regeneron is the team with a CEO shamelessly promoting a dangerous product.

Who where the twits that thumbed down the video? I bet it was trump and his pawns.

Spitting image have done a sketch “ how trump got COVID “ it’s funny ... on YT.....

anybody know what time it is?? brought to you by a guy wearing a bow-tie...... now really!!!

And Bloomberg with their Hopkins people demonstrates manifold incompetence. It is appalling.

The macro consensus paper is not useful

2nd in line again damn. Someday I'll be first one here..

Wear a mask? As if.

Stop moralizing about people’s behavior when it’s clearly the colder weather driving the spikes.

Favipirivir...

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Health Care Professionals are awesome! We respect you and love you! 👍👍💪💪