Type 1 Alzheimer's Disease
Type 1’s primary characteristic is inflammation. It tends to run in families as it is common in people who carry one or two ApoE4 alleles. Individuals begin to lose the ability to store new information in the hippocampus - for individuals who carry two copies of ApoE4 this tends to start in the late fifties or early sixties. For those with no copies of ApoE4, symptoms present typically in the sixties or seventies. A reduced hippocampal volume - chronic inflammation encourages the brain to destroy synapses faster than it creates them.
Biochemical Markers of Type 1
• An increase in C-reactive protein (CRP), which is made by the liver in response to inflammation.
• A decrease in the ratio of albumin to globulin.
• An increase in interleukin-6.
• An increase in tumor necrosis factor.
• Additional metabolic and hormonal abnormalities such as insulin resistance
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7 июл 2024
