Mutations and Types of mutations - This is the video on mutations, causes of mutations, types of mutations (Point mutation and Frameshift mutation) with NEET PG MCQs.
Definition of mutations - 00:21 minutes
Mutagens and Mutagenesis - 00:54 minutes
Causes of mutations - 01:27 minutes
Types of mutation - 02:27 minutes
Base substitution or Point Mutation - 03:29 minutes
Transition mutation and Transversion mutation - 04:13 minutes
Silent Mutation - 05:01 minutes
Missense mutation - 05:34 minutes
Acceptable Missense mutation - 06:17 minutes
Partially Acceptable Missense mutation - 06:54 minutes
Unacceptable Missense mutation - 07:55 minutes
Nonsense mutations - 08:47 minutes
Frameshift Mutation - 10:17 minutes
Point Mutation and Frameshift Mutation - 11:27 minutes
NEET PG Biochemistry MCQs - 13:05 minutes
#mutations #Genetics #molecularbiology #NEET PG #biochemistry
Mutation results when changes occur in the nucleotide sequence of a DNA.
The term mutation refers to the permanent changes in the DNA sequence.
Mutations in germ cells are transmitted to the next progeny and may give rise to inherited diseases.
Mutations in somatic cells are not transmitted to the progeny but are important in the causation of cancers and some congenital malfunctions.
Mutagens and Mutagenesis
Any agent which will increase DNA damage or cell proliferation can cause increased rate of mutations also. Such substances are called mutagens.
X-ray, gamma-ray, UV ray, acridine orange, etc. are well known mutagens.
The rate of mutation is proportional to the dose of irradiation.
Causes of Mutations
Errors in replication, If a mismatch base pair is not corrected during proofreading and post replication repair system.
Error due to recombination events.
Spontaneous change in DNA, e.g. deamination of cytosine to uracil or spontaneous depurination.
Environmental factors like chemical mutagens and irradiations, e.g. UV light or ionizing radiation can alter the structure of DNA.
20 май 2020
