Understanding Wilson's Disease 

I was extremely ill with Wilson's Disease in the late 1970s and all through the 1980s. My symptoms were neurological and psychiatric. I have been fine for decades and have a completely normal life.

My aunt and uncle are first cousins and they married 25-30 years back. Today, their 3 out of 6 children have this disease. They take copper chelating medicine on a regular basis and that’s what helps them get rid of excessive copper in their body. To whomsoever this may concern, you can live with the disease and have a normal lifespan if you promptly treat the disease. Wishing you happiness and praying for you to have a long and prosperous life.

As a person who has been diagnosed with the actual disease myself this video helps

Great presentation, very clear, consise and informative. Thanks

- In Wilson's disease, ↑ Free serum copper, but ↓ total serum copper. - Total body copper consists of ∼ 10% free copper and ∼ 90% ceruloplasmin-bound copper. - As tests detect copper bound to ceruloplasmin, total serum copper concentrations decrease with decreased serum ceruloplasmin levels. - Note that due to reduced incorporation of copper into apoceruloplasmin, less ceruloplasmin (copper transport protein) is formed.

I've had this desease since 2001. It almost killed me, but i'm doing great now. My liver is almost back to normal again. I still have some neurological things like cramps and muscle stiffness. I had all the symptoms, both neurological and liver. good video.

This is a very helpful video. I have a friend who has Wilson's Disease.

Excellent presentation and I hope your endeavors were successful. Very informative and you have a gift for presentations. Thanks again.

Not even a medico, still knows almost everything in brief 😅😅.. Credit goes to zero to finals.. ❤️😍😍😍😍😍.. Keep up the work brother.....

I was diagnosed with Wilson’s disease in 92 and I learned some stuff today

Thank you for the video!

Amazing video, as always. Entertaining, and above all informative!

Thanks for this video

The genome was mapped and the Wilson's gene has been found. It is now known that the Wilson's disease defect is in the binding of copper. It is a defect in the ATP7B gene and there are 6 binding exons on the gene. There are over 400 mutations that have been identified and more are being added to the database each year. In most mutations, only part of the exons aren't binding to ceruloplasmin, which still allows the body to bind and evacuate some copper, so the free copper gradually builds over time. In the rare severe mutations none of the 6 exons are binding copper and the free copper builds up in childhood. The defect is not in the inability to produce ceruloplasmin, as once thought, but the disease is caused by defective ceruloplasmin that won't bind copper. There are 2 types of copper, bound and unbound. Bound copper is non toxic and actually used by the body, but the unbound is toxic and like a heavy metal. In a normal person 5-10% should be unbound copper. How do you estimate free, or unbound to ceruloplasmin copper? You can do it by 2 methods. The old method, which is not that accurate is called an indirect measurement of free copper. You have your Ceruloplasmin (Cp) tested, along with your serum copper. Then you multiply the Cp x 3 and subtract it from the total serum copper which will give you the amount of free copper. Remember, the serum copper by itself will not be a diagnostic tool. The serum copper is a measurement of the total copper both bound and unbound. You must estimate the ratio of bound to unbound to see if you have a binding problem which is Wilson's disease. The 2nd method is a direct measurement of free copper lab test and it's the most accurate. Only a few labs are doing this test in the US, and Lab Corp is one of them. The free copper test # at Lab Corp is 279071. This is the test number at Oklahoma Lab Corps, and they may differ at the Lab Corp in your state. As far as the 24 hour urine copper test, it is not worth a sh*t. Medical literature says that this is the most accurate test, but it's worthless. Control group studies have been done and come to find out, people with Wilson's disease actually secrete less copper out their urine that normal people do. The only way this test is any good is if it's used with the penicillamine challenge, where they administer the drug to mobilize copper from the tissue before the test. Penicillamine is so toxic and has so many side effects that it should not be used period. There are much safer drugs out there. Penicillamine has put people into a permanent vegetative state because it is too aggressive at mobilizing the free copper and floods the brain with free copper. Zinc is a safe but slow chelator of copper. The compound ammonium tetrathiomolybdate (TM) is also safe and much faster than zinc. If you have one of the mutations where the liver is storing the copper, you need to use trientine. New research is now showing that liver involvement is rare in Wilson's disease. It's still a mystery why some people's livers start storing the copper and others don't. Family members with the same mutation have been found and only one person in the family has copper liver storage. New research is also showing an elevated free copper is the cause of schizophrenia, Parkinson's, ALS, Alzheimer's and Tourettes. Anyway, you can't rely on the medical books when it comes to Wilson's disease because they have inaccurate outdated information. If you think you have it, just go get the direct measurement of free copper lab test done. If the free copper is high, this means you have a problem. If the free copper is below normal, this means you also may have a problem, because when the liver starts storing the copper, it causes it to be low in the blood. The body produces Ceruloplasmin by the amount of copper it detects in the blood and when the liver starts storing it and the blood becomes low, the Ceruloplasmin production will be turned off by the body and it will become low. Most people with Wilson's will have a normal serum copper and a normal Ceruloplasmin. As mentioned before, it's not an inability to produce Cp, but it's defective Cp that can't bind copper that causes the problem. Just get the free copper test and start taking zinc 50mg 3 times a day, one hour before or 2 hours after meals. Zinc is a primer for metallothionein in the intestines, which latches on to the copper. Since the intestinal cells turn over every 8 days and new ones are formed, the old metallothionein copper filled cells are sloughed off out the stool and the process starts all over. This is how zinc gets copper out of the bloodstream. Zinc also blocks its absorption. It takes 9-12 months for zinc to bring a person to a non toxic copper state, whereas TM can do it in 2 weeks. In 8 weeks TM can totally decopper the body whereas zinc will take several years. Once decoppered you still need to take zinc daily to prevent the free copper from building back up.

Thank you my friend a lot .

Verry good explanation

Nice and precise

I have started ayurvedic treatment for one patient and result is just a miracle

thankyou, its so helpful

Great video

You have made a great video.

Loved this ❤

Thank you sir!

My son has Wilson's disease with liver, neurological and psychiatric symptoms, been on penicillamine for 10 years, very poorly by the time he was diagnosed aged 26

Thanks alot,, very informative

Zero to finals- please respond because my son is in the Memorial Hermann hospital in the Houston, Tx. Medical center due to cirrhosis of the liver caused by Wilson’s disease. The more I learn about this disease the more I realize how terrible it is. He is depressed, but I thought that was mostly due to the overall situation. He hasn’t shown neurological signs otherwise. He was perfectly normal and fine up until about two months ago. Fatigue, vomiting blood and other symptoms drove him to the ER. It still took several hospital visits before these “doctors” realized and correctly diagnosed what was wrong. As a man of fifty-two years and extensive experience with hospitals and doctors, the best advice I could give to any medical student, nurse or doctor is this: NEVER PRESUME A DIAGNOSIS OR ASSUME THAT A PATIENTS LIKELY CONDITION IS THE CORRECT AND TRUE DIAGNOSIS!!! The doctor automatically assumed, and in fact accused my son of being an alcoholic because he had severe cirrhosis of the liver. At twenty four years old. Sure, sounds logical to me. Asshole. Like most “medical professionals” are. Don’t be that.

amazing video thank u

Thank you

Very pleasant voice

Excellent

i got this condition in DOCTOR HOUSE M.D SERIES S1E6 and got interested. thanks alot

So helpful

Very nice video

All video is highlight

very helpful

Thank you❤

thank u soo much

Blood Ceruloplasmin level is decreased in case of wilson's disease.....

Brillant Vid

thank you alottt

What are the home remedies

Hi, I have a question - My notes say there should be: reduced serum caeruloplasmin reduced serum copper (counter-intuitive, but 95% of plasma copper is carried by ceruloplasmin) increased 24hr urinary copper excretion Presumably serum caerulosplasmin and copper are reduced because the copper is all deposited in the tissues. But why is there Increased urinary excretion? I thought the whole thing is that it's trying to hold on to copper so there would be less excreted? Thank you!

Dude! I have this!!

Hepsinbelirtilerivar ben de gözümde ķaybettim rabibim yardımcımız olsun wilson hastalığın yakalanbenimgibi olan arkadaşlar ında bütün hastalara şifa versin amin

Good

HI my brother has suffering from Wilson disease ...plz tell me how to treat it...

Thanks for the info , Just watched house and searched for this lol

Can Wilson's disease also cause adhd In some people?

Wilson disease ruined my brain, i used to be extremely violent. My old grandma tought i was posessed specially when the tremors came.

in the vid 2:10 "parkinsonism symmetrical" in notes "Motor symptoms are often asymmetrical in Wilson disease" - which one is it?

Sir when i was 15 years old my urinary cooper was 411ug /d is this normal or very high now I'm 18 years old I'm feeling better than that

High or low serum copper?

Two family members died from Wilson disease And now Two more fighting Wilson disease May Allah bless them

I came here because if the episode of house. Interesting disease.

Hello, i am from Bangladesh. I have wilson disease. So i want to talk with you doctor.

1 person got their question on Wilson's Disease in their exam wrong

Why the serum copper is decreased ? I am lost.

Serum Cu ?

My doctor told me yesterday. I might have Wilson's disease.

My face changes shapes everyday and it prevents me from going out and I have Wilson’s disease and I’m wondering if that is the cause of it I’m 54 and this has been happening my whole life

why serum copper low in Wilson disease when it should be high?

I had a copper iud, that leeched excessive amounts or copper into my blood. After removal, and radiotherapy coupled with lots of zinc, I am almost totally 100% back to normal. The psychiatric symptoms were what sent me to the hospital and that's when they saw the rings in my iris.

My little sister died by this disease in 2018!

My brother died from this disease and my sis has it😢

Penicillianine Trientene

they call it Hepatolenticular degen. now

♥

I have one but I'm 13 I im scared

انا واخي توأم مصابين بي مرض داء ويلسون

Hi i am from India.. I have willsion disease 🙁

💌

Low ceruloplasmin indicates Wilson's not high. This is inaccurate information

Reading the books of the New Testament, we perhaps asked ourselves more than once: *"Why 2000 years we do not see those miracles that accompanied the Сhurch of Christ in the I century, as described in the New Testament?"* Why do the so-called preachers of Christ have to prove that Jesus really existed and atheists boldly deny the historicity or divine origin of Christ? Maybe because the Сhurch of Christ has not existed for 2000 years? The Сhurch does not exist in the form in which it is presented in the books of the New Testament, but there are Catholic, Orthodox, Protestant and other christian sects claiming to be the place of the Church, but they not have the only thing that distinguishes the divine from the human and is characteristic of just the Сhurch of Christ -the reinforcement of the word with signs, that is, miracles (Mark 16:15-20). Therefore, some researchers doubt the historicity of Christ, and some of them are not opposed to declaring him a an ordinary philosopher, teacher. But even if Jesus were an ordinary philosopher, his disciples would be ordinary followers of Jesus. And they would not dare to write about the miracles that not only Jesus, but also his disciples, could perform. If there were the Church in our time as described by the authors of the New Testament books, where miracles are performed, the sick are healed, where prophesied, and the dead are raised, no one would doubt the historicity of Christ. Then there would be the same controversy throughout the world as in the first century - Jesus the Son of God or the false prophet who seduces the world by miracles. As a result, we can say that the emergence and development of christian sects and atheism was the result of the fact that over the 2000 years the Сhurch of Christ did not exist. Find *"The Mystery about the Church of Christ"* video on RU-vid. The video reveals the prophecy of the disappearance and reappearance of the Church of Christ before the End of the World. Watching this video will give hope to all who sincerely seek God and will interest those who are not too lazy to think freely. Click on my name to watch the video (The video is in Russian, but English subtitles are included).

Hair test holy mother

I bid a very good bye and safe journey to my dear most sweetheart😔 who has lost her life of the disease called Wilson's disease. I pray that Father in heaven shall lead me till I breadth last and we shall meet again in heaven

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Our last name!

Wilson deases ..is a bad luck..

This kid thinks he's a vampier he eats dark chocolate if you see his eyes they have copper in them he has broses on him and his girlfriend but no copper in her eyes 👁🧠🦴

dude i fell asleep

Honestly providing false information in your lessons even if there are only a couple of them is a big no-no in these kind of videos. You should double check the informations that you are providing!

o w ta ad atp

Thank you