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Use Gene Editing to Treat Patients, Not Design Babies | Marcy Darnovsky | TEDxLagunaBlancaSchool 

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Marcy Darnovsky, PhD, is Executive Director at the Center for Genetics and Society, a California-based public interest organization that works for a world in which human genetic and assisted reproductive technologies benefit the common good. Marcy’s talk covers exactly that. She has recently focused on the prospect that heritable genome editing could undermine our chances for an inclusive future. Her articles on this have appeared in publications including The New York Times, Los Angeles Times, National Geographic, and others. Dr. Darnovsky addresses the pros and cons surrounding programs such as CRISPR, focusing on gene editing.
Marcy Darnovsky, PhD, is Executive Director at the Center for Genetics and Society, a Berkeley, California-based public interest organization that works for a world in which human genetic and assisted reproductive technologies benefit the common good. Darnovsky speaks and writes widely about the social justice and human rights implications of human biotechnologies. Recently she has focused on the prospect that heritable genome editing could undermine our chances for a fair and inclusive future. Her articles on this topic have appeared in publications including The New York Times, Financial Times, Los Angeles Times, The Guardian, The Hill, National Geographic, and Nature. She is co-editor, with Osagie K. Obasogie, of Beyond Bioethics: Toward a New Biopolitics (University of California Press, 2018). She has been interviewed by hundreds of television, radio, print, and online outlets. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at www.ted.com/tedx

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2 июн 2024

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Комментарии : 40   
@unluckyduck3474
@unluckyduck3474 3 года назад
TBH I'm just here for a school assignment
@brandiicakes1437
@brandiicakes1437 2 года назад
same
@LianaBuzea
@LianaBuzea 2 месяца назад
I very much appreciate this take and the three questions / points brought up. Thank you for putting this out here! 🙏🏻
@LuisOrtiz-ey1bp
@LuisOrtiz-ey1bp Год назад
I understand why we can't do "designer babies", who wouldn't want a child that's immune to horrible diseases, physically superior, and smart? Ethics get in the way of a lot of progress that could be made in our lifetimes.
@magicray5088
@magicray5088 Год назад
yewah!! that should only be allowed to the wealthy and the privileged folks, god, it makes me so mad when people get out of their own lane and forget their place in this world... We need protection from such advancements , in truth everyone should tread lightly not just some people....
@hannahm9083
@hannahm9083 3 года назад
I'm surprised she didn't mention anything about unborn children's consent! Because people who'll be affected by germline gene therapy aren't born yet, they can't choose whether or not to have the treatment.
@visionentertainment8006
@visionentertainment8006 Год назад
A baby doesn't consent to being born at all. Yet it doesn't stop people.
@williambudden7066
@williambudden7066 Год назад
Not like we consent to anything anyways when we’re born. So who cares 🙄
@stelladimitrova4169
@stelladimitrova4169 Год назад
As if a child is gonna say "omg, how dare you making me better, I wish I was born untalented and with heredatel diseases".
@visionentertainment8006
@visionentertainment8006 Год назад
@@stelladimitrova4169 Exactly😂
@RiverBrook
@RiverBrook Год назад
Marcy Darnovsky brings up some great points in her TED talk on gene editing. She draws a very distinct line between the use of CRISPR Cas9, that being those that are using it to create the perfect child to those that are wanting to use it for gene editing to treat DNA afflictions. To be clear, I support this distinction and am leaning more towards the same side as Darnovsky of using it for gene editing diseased patients such that their pathologies can be erased. I believe that what Dr. He did with editing the CCR5 gene, a critical component to HIV infection into CD4+ T cells, in the two children such that they would become resistant to HIV was morally and ethically wrong. This is due to how he jumped passed a lot of clinical trials necessary to confirm the effectiveness and safety of gene editing on top of not fully informing about the treatment plan with the parents. Not only did this violate a very important and critical component to medicine of informed consent but also non-maleficence (do no harm) and autonomy (the right to choose). I am shocked that he correlated gene editing to a vaccine when informing the parents. CRISPR in the literature has shown to be able to alter site specific programmed changes but as a negative side-effect it can also perform off-target effects as stated by Uddin et al (CRISPR Gene Therapy: Applications, Limitations, and Implications for the Future”). There has been some movement to improve the decrease in off-site targeting like using Nanoplasmids, but still there is much work to be done in the scientific community in terms of efficacy. Not only was this treatment unethical, but we still don’t know the severity of the repercussions of Dr. He’s actions in terms of off-site targeting as well as the babies future health and subsequent generations. I know that there is a lot of negative push back from Dr. He’s actions but I hope that it doesn’t derail gene therapy. For instance, if we look at Huntington’s disease with a repeat of nucleotides CAG, what if we had a tool that could go in and remove these repeats that play a crucial role in the pathophysiology? Essentially, this could offer a solution to those facing this debilitating affliction that affects the nervous system. Or if we look at the TTN gene mutation in familial dilated cardiomyopathy, what if we could have a tool that could go in and correct this mutation that predisposes individuals to heart failure? Lastly, I do believe that if the world does come to designer babies that this could divide the world. I correlate it to those in the Olympics going up against a person that is taking steroids, it just wouldn’t be an equal competition and thus creating more divide into a world that already has so much division. I strongly believe that there is a need to create further protocols such that designer babies don’t become the future.
@tommasinibafford7272
@tommasinibafford7272 4 года назад
Very interesting presentation.
@henrydejesuspuellomercado2529
@henrydejesuspuellomercado2529 3 года назад
Puedo conseguir este video con traducción al español.
@RiverBrook
@RiverBrook Год назад
Very interesting perspective
@leonardo2108
@leonardo2108 2 года назад
I didn't clearly understand why it would be a bad thing though
@aieshaoliver
@aieshaoliver Год назад
How about we leave people's genes alone and allow fully consenting adults to have children with whom they want.
@Smurf_Garden
@Smurf_Garden Год назад
don't prevent the inevitable, just give the profession a list of ethical standards and have them accountable to a professional board like every other doc in the medical field or in psychology.
@Deedlanger
@Deedlanger 2 года назад
I would rather be modified to live a life where i won’t suffer than to live in this imperfect body. If this body gets too old and useless i may as well kill myself than to keep living in an old body that loses its privilege to drive cars and do normal human activities.
@danielmoore4024
@danielmoore4024 Год назад
Are you aware what you're suggesting is what caused World War 2?
@elafalibrahim9828
@elafalibrahim9828 4 года назад
It is interstellar, but reading from papers was annoying
@nerif2849
@nerif2849 4 года назад
E.
@ellish1ashir569
@ellish1ashir569 4 года назад
Lol how naive can she be... Aahhh... The 1% will laugh their asses off if they ever see this 😂😂
@lkb4781
@lkb4781 3 года назад
I find it interesting that all the people who are against designer babies are frumpy and goofy looking. Such a weird coincidence.
@barbieanniefrenchie7868
@barbieanniefrenchie7868 3 года назад
same, they're jealous that some people just won't have an ''equal" advantage. they themselves are not attractive and wish for others to not have that great advantage my friend.
@moonchaf
@moonchaf 3 года назад
What did I just read lol. Its basic ethics to consider all the possible aspects and incomes in terms of making a big decision like this. She made really good points about inequality and the fact that there will be alot of standards that make people want to modify their baby to look caucasian (blue eyes, fair skin) which is a huge issue considering that most people think that us white people hold a different type of title when it comes to power and money. This will only add to inequality between races and different socioeconomic classes.
@bored_potato
@bored_potato 3 года назад
​@@moonchaf True, and I haven't yet watched the entire video but I think she's right on her main point which to use genetic engineering only for diseases and not "customize" babies like sim characters. Calling these people who question the idea of editing the looks of unborn babies "weird' or "goofy" is also just plain childish, as well as countering it with "they're just jealous that blah blah". Unlike most of the comments in this video, there are actual people who consider the ethics of genetic engineering. Is it really possible? Is it only limited to diseases? Is it really right for everyone to design how their babies would look like and not let them born with whatever their genes would come up with? It's rather similar to plastic surgery, (not completely but it has similarities), it used to be only for fatal accidents/incidents that fix let's say a torn off skin but now people are just using it just because they can. Maybe the people who ridicule speakers like her can't understand this or refuse to understand this side of the argument, but this is genetic engineering, it might as well be tampering with life itself (kinda exaggerated but still). All sides and angles MUST be considered. They ought to think critically before commenting something that's just plain childish.
@YA-kr4fr
@YA-kr4fr 3 года назад
@@moonchaf intelligence is a bigger factor than race
@Andrea-sg2yk
@Andrea-sg2yk 2 года назад
@@barbieanniefrenchie7868 a baby is not a toy....
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