Viral Vectors Overview 

Viral Vectors Overview #biotechnology #genetherapy
This video is about the viral vectors used in gene therapy, Retroviruses, adenoviruses, pseudotyped viruses, and herpes simplex virus
Viral vectors are one of the most commonly used methods for delivering genes into target cells in gene therapy. They are derived from viruses that have been modified to remove their disease-causing properties while retaining their ability to efficiently deliver genes to cells.
One type of viral vector used in gene therapy is the adenovirus vector, which is derived from the adenovirus. Adenovirus vectors have a high efficiency of gene transfer and can infect both dividing and non-dividing cells. However, they can elicit an immune response in the body, which can limit their effectiveness for repeated administration.
Another type of viral vector is the lentivirus vector, which is derived from the human immunodeficiency virus (HIV). Lentivirus vectors can integrate their genetic material into the host genome, allowing for long-term gene expression. They also have a broad cell tropism, which means they can infect a wide range of cell types. However, their use can raise safety concerns due to the risk of insertional mutagenesis, where the integration of the vector into the genome can disrupt normal gene function.
Other types of viral vectors used in gene therapy include retrovirus vectors, adeno-associated virus (AAV) vectors, and herpes simplex virus (HSV) vectors. Each of these vectors has its own advantages and limitations, and the choice of vector depends on the specific therapeutic application and target cells.
In summary, viral vectors have been widely used in gene therapy due to their high efficiency of gene delivery and ability to integrate into the host genome, allowing for long-term gene expression. However, safety concerns associated with viral vectors have led to the development of non-viral vectors as alternative gene delivery methods.
Part 1: • Types of Therapy: Pla...
Part 2: - • Basics of Gene Therapy...
Part 3: • Types of Gene therapy