DUDE, SERIOUSLY, your videos are the best. Thank you for all the great work, If I could subscribe more than once, I'd do it. You just saved me pages and pages of studyin in a 9 minute long and clear video. Thank you.
YOU ARE AMAZING! I'm such a visual person and all of this... what you're doing... Everything just stays in my brain after one time of watching! No Kidding! THANKS!
Thank you so much . everything you explained was crystal clear and you explained in such a way that my mind was able to retain it just by seeing your video once. Best of luck for future and stay bless
We have been screaming to be heard for my daughter's MS related symptoms, and your video explains so much that we can now take to our deficient doctors. Thank you to taking a very complex issue and explaining in a way that we could learn it. Amazing!!!
Wondering just what your daughters issues are? I’m recently diagnosed and having digestive issues that let me to this video after months of research. Wondering if vitamin b is the issues, hcl, pepsin OR none of the above.
Well, I, personally got my b12 results back (actually saw a hematologist to make sure I’m actually absorbing the b12 I’m taking) and my b12 is good so has to be something else. What are your daughters issues. I know she has ms but my symptoms appear to be TOTALLY unrelated. Docs response….well, you have ms. Still digging! Look @ Epstein Barr. That’s where I’m headed. Good luck to you. Your daughter is in my thoughts.
Armando, you are amazing ! It is so easy to understand all those topics you tackle through your excellent drawings and explanations. Also you have a nice humble way about you. I hope you get into teaching as doctor! Your students will thank you!
Comment from a different video, copy-pasted: "I'd like to add something about the weird terminology here, just details but might help someone: 1) haptocorrin = transcobalamin I (and I think formerly aka transcobalamin III) = cobalophilin = R-protein = R-factor = R-binder ("R" stands for "rapid electrophoretic mobility"). 2) The intrinsic factor receptor in the terminal ileum is also called "cubilin"; the receptor in the kidney that's responsible for the B12 reabs. is the same like the one in the terminal ileum (it is also cubilin!) with the small difference that megalin was added to this receptor (which means this receptor is more "elaborate" than the one in the terminal ileum). Also, in order for cubilin to work, you need a membrane protein that will make cubilin stay put (and will help in the endocytosis, once B12 bound), this protein being called "amnionless". 3) A mutation in cubilin or amnionless (autosomal recessive) leads to the Imerslund-Gräsbeck syndrome (syn.: defect of enterocyte intrinsic factor receptor, enterocyte cobalamin malabsorption, megaloblastic anemia 1, juvenile pernicious anemia with proteinuria due to selective intestinal malabsorption of vitamin B12), 1:200k in Finland/ Norway --> patients will have problems with both, B12 abs. AND reabs (remember, cubilin/ amnionless is present in both organs). 4) B12 bound to transcobalamin II (the transporter in the blood) is called "Holotranscobalamin" ("active B12"). 5) Haptocorrin is also produced in the stomach, not only by the salivary glands; and, as said in the vid, haptocorrin can bind 80% of the B12 in the blood making it unavailable for use." If you want to add/ correct something, feel free to do so
@sanju b I don't have my notes next to me but paper says "[...] Intrinsic factor is produced by the gastric parietal cell. Its secretion is stimulated via all pathways known to stimulate gastric acid secretion: histamine, gastrin, and acetylcholine [...]" pubmed.ncbi.nlm.nih.gov/1775933/
@sanju b I am assuming you have a "regular" B12 deficiency (i.e., due to your diet), in that case don't worry about increasing IF, just take the supplements your doc prescribed you and you will be fine
5:30 What if I have a Transcobalamin deficiency? (My blood test reads as half the lower range of reference interval.) I do have some TCN2 gene variants, but I can't seem to find anything online about these specific variants. Is Transcobalamin supplementation a thing? My serum B12 is normal to high, depending on how much I supplement.
I have been talking suprdyn and folic acid daily since long as then deficiency was noticed.some shots were given and then d above medicine. It was 346 in August but in Nov. It is 1052. What should I do Sir.
Another great video. One major cause of B12 deficiency which I was surprised you didn't mention is alcoholism. I will assume this is due to alcohol damaging the illium and preventing adequate absorption. Additionally alcoholism generally goes hand in hand with poor diet/malnutrition which also accounts for the deficiency.
@@lynserkawi4704 yes, it does indeed take years to deplete stores of b12. 10 years is more in the realm of a theoretical maximum depletion time, but in practice the depletion time is around 2-4 years. In a liver damaged by alcohol, it cannot store as much b12 as a healthy liver so this is a factor as well. Interestingly, serum b12 levels can appear normal in those with severe alcoholic liver disease as the b12 can be "leaked" by the damaged liver which masks the otherwise low serum b12.
also i heard that Prilosec stops b12 absorption so what if someone takes Prilosec for 2 years? are you b12 deficient? I've stopped taking it now and try to eat eggs everyday, but still have some anemia... i don't eat red meat and only dairy and egg and sometimes chicken. is that enough or do i need supplement?
American Academy of Neurology: People with inflammatory bowel disease may also be at risk for developing nerve damage and other neurological problems, according to research that will be presented at the American Academy of Neurology’s 59th Annual Meeting in Boston, April 28 - May 5, 2007. Inflammatory bowel disease includes digestive disorders such as ulcerative colitis and Crohn’s disease that cause swelling and/or bleeding in the intestines. For the study, researchers compared 103 people with Crohn’s disease and ulcerative colitis to 51 people with other digestive disorders, such as irritable bowel syndrome, gastritis and chronic heartburn. The researchers found that those with inflammatory bowel disease were about four times more likely to develop neuromuscular conditions, including carpal tunnel syndrome and small fiber neuropathy, which causes pain and lack of feeling in the feet. Those with bowel disease were also more than six times more likely to also have a disorder called sensorimotor polyneuropathy, a nerve disease that can cause weakness, pain, and numbness. These diseases were more common in women with bowel disease than men. “Inflammatory bowel disease patients commonly suffer from several other medical conditions, like B12 deficiency and glucose intolerance. These nerve conditions we have reported are often not diagnosed by their primary care physicians,” said lead study author Francisco De Assis Gondim, MD, MSc, PhD, Professor of the Federal University of Ceará in Ceará, Brazil, and a member of the American Academy of Neurology. “People with inflammatory bowel disease who develop new symptoms, such as pain or numbness in the feet, should see a doctor.”
what is the advice for someone on omeprozole for ulcer issues and also metformin for diabetes. Will b12 supplements be adequate or will b12 have no effect because of lack of stomach acid needed for b12 to work effectively.
Hi my b12 level is 88 I recently feel very low and disturb walking so i give a sample but the question is do menstruation periods cause b12 low level bcz i eat all type of animal origin food then why my level is too low
Exellent stuff mate! Just keep on going. Surely one of my favorite medical channes on YT. Could you please do review on Vitamin B1 and also its deficiency? Cheers :)
Adds greater understanding - or should that be interesting facts which take even more understanding , patience, digesting and much more familiarity ( Ha! well so be it )
Please somebody help me. I’ve just realized the reason I have b12 issues is stomach acid related but I also have extremely high cobalt which is toxic obviously because my body hasn’t been working the way it’s supposed to. How do I take b12 and absorb it without the extremely high cobalt happening?
Just found this video. It ended too abruptly. I was recently diagnosed with PA and after a year of weekly B-12 injections I still suffer. My doctors don’t understand the science behind it so they keep passing me around from one specialist to another. I’m only 58. There must be more that can be done for me then just B-12 injections. Anyone else feel the same way?
