What if Osimertinib Stops Working? - 2022 Program: Targeted Therapies Forum

GRACE - Global Resource for Advancing Cancer Education

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Targeted Therapies Forum 2022, Breakout Session: Dr. Angel Qin discusses next steps if Osimertinib stops working.
We thank our sponsors for this year's support! #Novartis #Janssen #Blueprintmedicine #TakedaOncology #Astrazeneca #LillyOncology #genentech
For more, please visit cancerGRACE.org/.
To join the conversation, visit cancergrace.org/forum.

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15 ноя 2022

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Комментарии : 5

@nathanibanez6398 11 месяцев назад

Thank you so much for this information. My grandma was diagnosed with NSCLC with EGFR exon 19 deletion. Before this diagnosis she was diagnosed with possible LMD and had WBRT. She started tagrisso about 20 days ago with no side effects, and there have been lots of recovery so far. We pray and hope that tagrisso works for as long as she is alive.

@CancergraceOrg 11 месяцев назад

I'm sorry your grandma has nsclc. But very glad she is on tagrisso now without side effects and feeling better. Here's to a long long benefit.

@henriettahussey2536 8 месяцев назад

Hi my father in law has nsclc egfr lung cancer that had a micro metastasis in the brain which was removed with cyber knife. His latest MRI shows the tumor in the lung has now reverted back to the size when it was first discovered. He has been treated with osimertinib which shrank the tumor in the first 3 months by a third from 3cm to 2cm. The next scan showed it was still at 2cm and the latest is showing it’s back at 3cm. He has had a second opinion with a professor who said he can surgically remove the tumor but his oncology team are not happy with taking that route as they feel it could make the cancer aggressive and form a tumor/s elsewhere. He is due a PET scan in a couple of weeks and some other tests to see if it has mutated. We are so very worried as we have conflicting advice about the surgery. What are our options if the osimertinib has stopped working if 1. The cancer hasn’t mutated and is the same and 2. If it has mutated. Also is there more of a risk having surgery with this type of cancer or is it because it had already metastasised to the brain (which is all clear now)?

@CancergraceOrg 8 месяцев назад

Hi Henrietta, I'm sorry about your father in law. If the brain met was the only metastasis and was completely removed then the primary could be considered the only remaining cancer which would make surgery an option if the tumor is otherwise considered operable. This is known as oligometastasis more on that here, cancergrace.org/post/importance-oligo-oligometastatic-or-oligoprogression. Ideally, the 2nd opinion is gotten from a specialist at a large academic research center. That specialist would be willing to advise who would be best to perform the surgery (or SBRT if unresectable). A lot of decisions depend on the individual's health/performance status, location of tumor, and willingness for whatever treatment. If it is found that the cancer has spread and tagrisso is no longer working anywhere then he could look into clinical trials (that specialist could help with that too). After using all TKI options then chemo/immunotherapy would be considered next. I'd certainly look into the oligometastasis options first. With surgery or SBRT there is possibility of cure. Systemic treatments aren't (haven't yet been) curative on their own. Best of luck, Janine

@henriettahussey2536 8 месяцев назад

@@CancergraceOrg Thank you so much for your valuable advice I will pass this on to my husband.