What is chronic myelogenous leukemia? | Hematologic System Diseases | NCLEX-RN | Khan Academy

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Learn what is chronic myelogenous leukemia as well as how to identify its signs and symptoms, diagnose it, and treat it. By Raja Narayan. Visit us (www.khanacademy...) for health and medicine content or (www.khanacademy...) for MCAT related content. These videos do not provide medical advice and are for informational purposes only. The videos are not intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of a qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read or seen in any Khan Academy video. Created by Raja Narayan.
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30 сен 2024

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Комментарии : 85

@twang2884 3 года назад

I just like to add one thing about your video regarding elevated WBC in CML. The increased WBCs production in the bone marrow are actually defect cells, which couldn't function normally to fight Bacteria, fungi, or viruses and result in fever with opportunistic infection

@lemhairbi Год назад

This video is eye opening. Thank you very much for it.

@cmlarabnetwork819 7 лет назад

Nice way to explain and to understand

@hasanalmonem5713 8 лет назад

awesome..i wish teachers were this good in classrooms..o how i wish!!

@divanshijoshi9664 8 лет назад

HASAN AL MONEM

@tomasschalksoleyjarson8871 5 лет назад

i had 500k wbc when i was diagnosed, its now 6 months later and im fine just have to take medication daily.

@tamerasimonson1726 4 года назад

I've had CML for over 27 years, did the Hydroxyurea for a few weeks and then Interferon for almost 10 years. Been on Gleevec (Imatinib) since December 2001 and am VERY grateful for that. But am upset that they say things about Imatinib like "as a rsult, you can actually cure cancer, cure CML". Imatinib puts us in a remission, but we are not cured.

@mpepper1977 4 года назад

Exactly! I didn’t care for that statement either!!

@dhananjay. 2 года назад

Please can you give me your telegram or IG or anything because i want to contact you regarding CML

@laureeeent Год назад

100% these meds cost a lot, have serious side effects and as a CML person too, there is the occasional health scares.

@beverlydawson7746 5 лет назад

Had Cml For ten years now been taking Glevece for the last ten years every day

@tedspeed3338 4 года назад

beverly dawson I’ve been recently diagnosed with CML. My doctor said it’s possible that in 2 years I may be able to go off Gleevec if my numbers are low enough. He has had several patients that have done this with success. (They still need regular blood tests to make sure they stay in remission). Has you doctor mentioned this to you? I’m hoping that I’ll be able to do this some day...

@mischiefmanaged3716 3 года назад

Hey, Can you tell me after how much time after diagnosis were you able to return to normal life

@waryee 9 лет назад

These are such amazing videos! Thank you for sharing your knowledge with us.

@MehadiLifeStyle 3 года назад

90% are alive at 5 years? What does it mean? Why can't we expect to live normal like 60 years where the enzime is blocked by the medicine.

@tyrhere 5 лет назад

Always a life saver. Do you update old videos if there are new findings?

@xDomglmao 5 лет назад

I don't get the part with the hepatomegaly and the BMR. More cells = more nutrients used/ more waste products produced = more detox needed = liver works more? Correct like this?

@mourilshah2054 4 года назад

Extramedullary hematopoeisis occurs in liver and spleen because bone marrow cannot produce enough rbc

@LeslieJeffs-jg8fj 3 месяца назад

This was a wonderful video. Explains the cml information so good, very easy to understand The very best I have watched. Thank you

@MalikaAubakirova 7 лет назад

This is a great video! Thank you

@hussainzuhajamz1420 2 года назад

Thnku so much sir😇😇😇

@bethminer7966 9 месяцев назад

So many kinds...my father had AML i have CML. He lasted 6 days after his diagnosis.

@شنوتعلمتاليوم 7 лет назад

thank you so much sir

@ela476 8 лет назад

Great way of teaching!

@杨跃-d1r 9 лет назад

really helpful! Will you explain NHL for us? Thanks very much!

@mdrahamatullahmd4574 11 месяцев назад

I have cll. I am fighting with this deadly disease. Give suggestion.

@jadahjared 6 лет назад

I have a question. My mother for years had an issue with her Leukocyte, they were always extremely elevate despite not having any infection. Her pcp refered her to a specialist. The BCR-ABL was perform on her and it came back positive. But we were never inform until aroung a month after she was also diagnose with breast cancer and her Oncologist suggested for us to go bak to the specialist because he needes to clarify on the BCR-ABL test. We went to back to this doctor and he said that often time the BCR-ABL test can be a false positive. Since we were already dialing with her breast cancer issue we left it along. But as time progress I notice that my mom had all the symtoms associate with CML. She was tested the second time for BCR-ABL and it came back negative. Can someone be BCR-ABL positive on the first test and negative on the second test? Please help. Hope to hear from you soon. Thanks.

@xDomglmao 5 лет назад

Not a medic here but I'd say the only way of being indeed BCR-ABL+ and then to NOT be + anymore is that all the BCR-ABL+ cells got removed.

@wanous151 7 лет назад

I was just diagnosed with CMML, what's the difference and treatment options?

@xDomglmao 5 лет назад

CML = usually involves neutrophils that go mad; CMML = involves monocytes that go mad. I can't tell you about the treatment options for CMML but for CML it's initially Imatinib and as last resort if one meets the criteria a BM transplant.

@haileybugggg 9 лет назад

thanks! It really helped me doing homework, as always:)

@clareosullivan9377 8 лет назад

Why is CML considered cancer but polycythemia vera and essential thrombocythemia are not?? Thank you :)

@AnneScrubsFan 8 лет назад

They are considered cancer as of now, because they found mutations in PV and ET as well (like JAK2 and CALR). That's why those two together with myelofibrosis are known as MPN: myeloproliferative neoplasms. Hope this helped :)

@xDomglmao 5 лет назад

@@AnneScrubsFan Good comment! Thanks!

@mtoralf 7 лет назад

I love this videos so much!!!! Thhank you

@pbp430 Год назад

Truly genuine explanation videos from the Admin. Thank Alot for making leukaemias easy to understand nd more conceptual.🙏🏻

@dr.shubhamagrawal8782 6 лет назад

Thank you so much

@newnew9048 3 года назад

Very beneficial/informative Vedio on CML (high White Blood cells ) WBC what IF WBC R LOW Can U pls make Vedio on it...thankyou

@ridwansalifu6987 2 года назад

I will be starting this topic tonight. But I think I've understand everything after watching this videos.

@kimsordyl Год назад

Love when they explain mechanisms that are responsible for generating certain symptoms - so much easier to memorize. Very good vids on leukemias.

@muhammedonel3644 3 года назад

Abl is not a receptor tyrosine kinase, it's a non-receptor tyrosine kinase, which is that it is found in cytosol and nuclear plasma

@JennitaRiv 7 лет назад

Soo soo good!

@wahahacoke 7 лет назад

i like khanacademy video information, but u could try using a light background if possible :)

@Senovia3728 5 лет назад

We DONT NEED TREATMENTS, WE NEED CURES. CANNABIS OIL WITH THE THC CURES MANY DISEASES & ILLNESSES.

@mdlaird2785 7 лет назад

Do you mean multipotent? Is it not only embryonic stem cells that are pluripotent?

@CrisURace 2 года назад

What do you know about Dasatinib?

@Jkstolz 6 лет назад

Has anyone with CML ever had a MOMO pregnancy?

@jillmarchand4738 7 лет назад

Thank you

@BeimnetMekete 6 месяцев назад

Good job continue

@rainabosworthf393 5 лет назад

My son has the Philadelphia gene does this mean he can't be cured

@guyhi11 9 лет назад

Wondering if you could clear something up: The previous video (on myeloproliferative disorders) states that the defect causing CML occurs after the myeloid stem cell phase. However this video states it's just after the pluripotent stem cell phase. Which is it? If it's after the pluripotent stem cell phase then what would make it different from polycythemia vera? Cheers

@Gjitra 8 лет назад

+guyhi11 CML occurs after myeloid stem cell phase

@12binitamajumder68 6 лет назад

It occurs from pluripotent stem cell with both myeloid and lymphoid potential

@64viikapilchouhan11 5 лет назад

It occurs in myeloid lineage of pleuropotent haemopoietic cell not directly pph..

@64viikapilchouhan11 5 лет назад

I replied after 3 yrs😂😂😂

@robelcheapo 7 лет назад

hi, what app do you use to make videos?

@WiltonAdrianoNeto 8 лет назад

I think that @2:35 he is actually describing AML no CML. Can someone verify this for me?

@Wonderlustbeauty 8 лет назад

CML as well, I have it and when it was out of control my platelets were extremely high

@imagination7710 8 лет назад

do you mean 'defective' cells

7 лет назад

Thanks a lot! Great video

@WhdibAoqj 8 месяцев назад

❤

@ari6i 4 года назад

thanks a lot 💐🦋💐💐

@7mariajoao 8 лет назад

Very good!! Thank you :)

@mananvaid2304 7 лет назад

But if the defect is at the cross you Made then lymphoid series should also get proliferated, shouldn’t they?

@ajiteshmishra472 5 лет назад

MANAN VAID actually mutation occurs in pleuri potent hematopoietic stem cells destined to produce myeloid series See pleuri potent cell can produce 2 types of cell myeloid series and lymphoid series...

@ridwansalifu6987 2 года назад

@@ajiteshmishra472 good answer. Even the name of the disease itself clarifies his question. The mutation is only affecting myeloid destined cells.