What you need to know about CRISPR | Ellen Jorgensen 

I wish TED did more of those scientific talks instead of yet another "inspirational coaching" CRISPR is one viral thing, but how about EM "Impossible" Drive or Recent nano engine...They only seem to be center on AI recently with hosts saying same things over and over again.

I know alot because of kurzgesagt

Once the technology is out, no amount of laws, moratoriums, or policy will prevent it being worked on in every conceivable way, be it rats, rabbits or humans. I don't think it is an inherently bad thing, but no doubt terrible things will happen along the way, out of sight. It is absolutely inevitable.

I want a mammoth steak but only if it's CRISPIER.

Y'all, get on board with this technology. I'd like to see my Aunt's Huntington's disease completely eradicated. I see her suffer. There are more people like my aunt that need this DNA editing. Let's not get stuck on super babies and wooly mammoths. Those are petty subjects to those who have little time left to live. The philosophical conversations are critical to understanding but all the talk seems to stymie a potential miracle for someone looking at only a few months or years remaining. The subject makes my heart race with hope but the conversations of morality put dark spots in that hope.

It's staggering how far along technology has come in my life time. I couldn't imagine this technology as a child....

Its kind of bummer to think my generation will be the last generation to NOT benefit from CRISPR..

I love how she summarized it all up into the final statement.

Science is hard work. There are people in their particular fields that make great contributions and never get recognized. To those people I would say thank you. You do the human race proud. Maybe you do it for the money, and/or fame, but you know what, if you're helping someone, that makes a difference. So again, thank you

thanks to kurzgesagt, i know what she's talking about... well most of it

I've never heard of it but it sounds delicious.

I think we should bring back the wooly mammoth, but like a miniature one the size of a small dog

wipe out the goddamn mosquitoes

I love this. Dare I say a faster delivery. Superb delivery by the way. You ladies know how to speak. Thank you

yeah , yeah , just give me super powers ^^

Thank you for this educational video!

"u cant just do this in your kitchen" as im doing my crispr experiments in my kitchen

Thanks dear for such a beautiful explaination

I’m so excited for the future

Great storytelling!

Excellent talk on a new discovery.

When it comes to CRISPR why is everybody going crazy about the wooly mammoth and blue eyes but nobody thinks about the lives it could save by curing diseases ? So excited for this. Imagine you can live happily with your family protected with an efficient healthcare. How peaceful.

1:43 - "That's how it works" ....... Nice graphic animation of how CRISPR works.

"You need a lab" -So does Meth

"How can we justify wiping an entire species that is harmful to humans off the face of the planet?" That question answers itself.

I feel like this is a really interesting thing but very very dangerous due to mistakes or people weaponizing it.

It's not a coincidence that she said the devil is in the details....and that's very scary

Really amazing lecture, than you.

Awesome Explanation mam😊

Very nice talk

"How can we justify wiping out an entire species that we consider harmful to humans, off the face of the Earth?" You just answered your own question; the species is harmful.

I hope that lots of good will come of this. I'm concerned that making these genetic changes will be as if you are pushing at the tip of an iceberg without realizing that there's a mountain of ice below the ocean's surface that you can't see yet.

Y'all go to Kurzgesagt it has the cutest animations and you really do pay attention to what the beautiful voice of a British man is saying ☺️

She is so real i love it

This reminds me of some of the missions in the show travelers

What I don't understand is, when Cas9 cuts the DNA, if it's only broken then shoving the two pieces together sounds right. If I'm mistaken and it cuts OUT a chunk, then I still don't quite grasp what the repair pathways have to do with anything. I did a bit of research, and I think the two pathways being discussed here are HR and NHEJ, but apparently homologous recombination, which is the supposedly more "interesting" repair pathway only occurs during meiosis. Other articles mention CRISPR being able to be applied to non-dividing cells that make up most adult tissue - which is quite obvious, or else it wouldn't be of much use to any living person - so that means it doesn't involve HR. So how does the cell respond when the DNA is cut? Or did I get the whole repair pathway thing wrong? When she said feed it a bit of DNA, does it mean to inject DNA and the cell just happens to find the piece lying around and use it to link the broken bits? Or was it carried with the cas9 protein? Also, apparently if you "blunt" the cutters of cas9, it makes the protein stay in place on the targeted gene and temporarily turns it off. How does that work? Really hope someone watching this knows a bit more about the topic than myself and can help me out a bit. Thanks internet. :)

I am kind of wondering if any natural disease mechanisms were able to utilize Cas9 or similar sequences...prior to the patent filings.

Will this work for a living adult?

At times my back hurts. Is it possible too... with CRISPR??? O.o

This was like watching someone give a talk about Napster in 1998

The anthropomorphization really helped me understand

I'm 14, and I'm trying to learn as much as I can about genetic engineering before University. If anyone knows of any articles or videos on CRISPR/Cas9 and genetically engineering/alteration please link them, I'd greatly appreciate any and all knowledge on the subject. Thank you!

5:41 oh ya? what if I like to do it on kitchen table...

和訳ありがとうございます。とても勉強になります。

6:30 Do we need to know all these reasons why. It's better to classify wich one does what. Eventually the reasons why will become clear.

Fantastic!

Thank U and God bless U

When is crispr cast 9 in gene editing going to be available for people that have cancer or something like that and that's all they want to do is to cure it

But I'm the best life form.

Ellen! Your hair is stuck you the mic!

I expected to learn more

Amazing an scary at the same time. In love with technology!!!!

I think CRISPR deserved a better presentation.

Anyone who is worried about CRISPR needs to consider what government has done to people.

Patent a technology when there are so many unknown consequences ? Seriously 😶

eugenics is a weapon. always has been always will be

on our road to make Frankenstein :)) its awesome

Can It change hair texture?

Dammit Jim! It’s OK Dr. McCoy

But why is it 20 base pairs on the RNA instead of 21? How could a stop codon work if the anticodon can't bond?

I know from experience that humans have a great way of taking great things and turning them into nightmares

I suspect that Crispr will become so cheap that is can be done on a kitchen table. It just needs one person who believes it is possible. And that person will be backed by the entire human population, and they will make it free and accessible for all and everyone. This is inevitable.

Nice video. Keep it up

yes gene-editing is exciting. when the strand is broken or torn apart, as such, much like tearing an arm from your body, no matter how many surgeries you get, you cant "get back" to the "original form". this "tearing" event will always a probably in this process.

I want to take this therepy/ treatment pl

You don't need a professional lab, you just need the equipment and necessary skill

Someone please put her the sunglasses 9:43 I take my hat off with that last minutes...

Interesting.

Ellen says, "...It is the system that we stole from an ancient, ancient viral immune system." She sounds like she knows a lot of important details. How do viruses have ancient immiune systems? She has somehow spoken inaccurately, but to what is she referring to by "ancient, ancient viral immune system". I think she has informed us of something around for a very, very long time. Remember what ancient Spartans were said to do with babies that cried? - They were thrown to their deaths. It seems long ago people knew something strange about how babies have evolved into technical innovations of babies that is know being done with improving genetic engineering. Ellen seems to be speaking in a made up way, but she also seems partly enlightened.

"Adaptation Is a sigh of Intelligence"... Well, this relationship is more close that I thought.

Can we reverse aging?

What is the success rate?

I want to work with these things. What do I need to study?

1:54 That sounds a little more like a Chain-Chom lol

about the Wooly mammoth: currently the climatic conditions might not be good for that. if the new ice age will appear, the chances might be higher ;P

What do you know about phenotypic revolutions?

my friend had a ted talk this weekend, when do ted talks usually get posted

Wtf....Licensing issues here we are. I really hate corporate entities. Just like google and apple.

And the money grubbing beat goes on. ...

She dropped some real knowledge there at the end. =]

Any iGEMers here? Heard quite enough about CRISPR for a little while... xD

"we all have a responsibility " to not let them do anything to our bodies with it until they know exactly what they're doing and cells no longer are compared to as " black boxes".

hmmm is there any posibility to bring back lost hair or not to loss hair mostly in men.🤔

Descubierto por un español, y no esta traducido al español. que hay que hacer para traducirlo?

Cas 9 is skin editing system?

gimme imortality.

the kurzgesagt is best channel on youtube

I saw that in a movie... the end was not good 😂😂😂

Watch the movie 'Gattica'

Where this treatment is available in India

"... the devil is in the details...put stuff in like a Trojan horse"

How much would it cost to set up my own lab?

there's one quastion ib my mind. If we use SCISPR-CAS in human body, will our immune system react to foreign protein CAS9?

The title is very misleading. She only explained how CRISPR works and what the real cost and difficulty is. She didn't explain what impact it can have on our lives, which is by far the most important question for non-scientists. The other TED talk about CRISPR was much better: "Gene editing can now change an entire species -- forever"

She is right in that most of us work for a living ... just so that the few can play god. Monopolizing on great discovers using a 'Patent' defeats the whole premise of civilized Law. We need to modernize our collective thinking patterns to account for everyone on the planet ... their contribution and share in the rewards.

while the good people who understand genetics are here I have a question , I hear about modifying genes as a future possibility how can you modify every DNA in every cell in the body of life organism . I understand how it can be done to embryos but how can it even be possible for a living organism ?? thanks

2 words, space marines

Man can this fix my hair? or more precisely the absence of hair on my head? i kinda went half bald at 17 (completely bald now) and goddamn did it hurt.

What effects would it (And future variations/advancements of it) have on living currently-existing creatures and humans? Like, if you CRISPR a live person to replace whatever genes control hair color, would their hair color slowly start to change because the default/natural state is now say black hair from blonde? Or something more extreme, could CRISPR be applied to transexuals? One of the more extreme but potentially possible examples (Compared to say turning humans into mutant ninja turtles or super soldiers). What are the boundaries of it?

Was the piece of hair by her cheek bothering anybody else? lol